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Publikováno v:
FEBS Letters. 595:2628-2637
We recently reported a physical interaction between the angiotensin II (AngII) receptor (AT1R) and thrombin receptor (PAR1) in HEK293 cells using bioluminescence resonance energy transfer (BRET) technology. This was characterized by thrombin trans-ac
Autor:
Vijay Kumar, Danish Idrees
Publikováno v:
Biochemical and Biophysical Research Communications
The post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodegeneration. Protein aggregation in brain can be considered as one of the important reasons behind the neurodegeneration. SARS-CoV-2 Spike S1 protein receptor bin
Publikováno v:
FEBS Lett
Pleiotrophin (PTN) is a potent mitogenic cytokine whose activities are controlled by its interactions with glycosaminoglycan (GAG). We examined the specificity of PTN for several types of GAG oligosaccharides. Our data indicate that the interaction o
Autor:
Giulia Vecchi, Christopher M. Dobson, Roberta Cascella, Michele Vendruscolo, Cristina Cecchi, Benedetta Mannini, Fabrizio Chiti, Giulia Fani
Publikováno v:
ACS Chemical Neuroscience
Alzheimer's disease, which is the most common form of dementia, is characterized by the aggregation of the amyloid β peptide (Aβ) and by an impairment of calcium homeostasis caused by excessive activation of glutamatergic receptors (excitotoxicity)
Publikováno v:
Biochemical and Biophysical Research Communications. 530:181-188
Desensitization of G protein-coupled receptors (GPCRs) represents a gradual attenuation of receptor responsiveness by continuous or repeated exposure to agonists. The most widely accepted molecular mechanism responsible for desensitization is that of
Publikováno v:
FEBS Lett
Inflammasomes are cytosolic multimeric signaling complexes of the innate immune system that induce activation of caspases. The NOD-like receptor NLRP9 recruits the adaptor protein ASC to form an ASC-dependent inflammasome to limit rotaviral replicati
Autor:
Stephen L. Atkin, Amirhossein Sahebkar, Parvin Zamani, Jamshid Gholizadeh Navashenaq, Reza Kazemi Oskuee
Publikováno v:
Progress in Biophysics and Molecular Biology. 150:50-61
Inflammasomes are a group of cytosolic multi-protein signaling complexes that regulate maturation of the interleukin (IL)-1 family cytokines IL-1β and IL-18 through activation of inflammatory caspase-1. The NOD-like receptor family, pyrin domain con
Autor:
Changwei Liu, Leng Ni, Rui Zhang, Xuebin Wang, Baitao Ma, Xudong Liu, Zhewei Zhao, Rong Zeng, Xitao Song, Ye Bian
Publikováno v:
Biochemical and Biophysical Research Communications. 519:402-408
Endothelial dysfunction (ED) is a crucial and initial stage for the development of cardiovascular diseases. Accumulated evidence has demonstrated causative links between cigarette smoke (CS) and ED. However, the underlying mechanisms remain largely u
Autor:
Brett D. Noerager, J.E. Blalock, Tomasz Szul, Matthew T. Hardison, Xin Xu, Preston E. Bratcher, Liliana Viera, Kristopher R. Genschmer, Derek W Russell, M. Abdul Roda, Amit Gaggar
Publikováno v:
Biochem Biophys Res Commun
Neutrophil influx and activation contributes to organ damage in several major lung diseases. This inflammatory influx is initiated and propagated by both classical chemokines such as interleukin-8 and by downstream mediators such as the collagen frag
Publikováno v:
Biochemical and Biophysical Research Communications. 516:1252-1257
Intracerebral hemorrhage (ICH) is the most common of stroke with high mortality and severe morbidity. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a neuronprotective role in ICH. In the current study, TRIM37 mRNA expression in peri