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Publikováno v:
FEBS Lett
Chlamydia trachomatis, an obligate intracellular bacterium with limited metabolic capabilities, possesses the futalosine pathway for menaquinone biosynthesis. Futalosine pathway enzymes have promise as narrow-spectrum antibiotic targets, but the acti
Autor:
Cleophas Cheruiyot, Antje D. Ebert, Jonathan Bodenschatz, Ruheen Wali, Michael Habeck, Andreas Janshoff, Hang Xu, Gerd Hasenfuss
Publikováno v:
FEBS Letters. 595:2544-2557
We developed an integrated platform for analysis of parameterized data from human disease models. We report a non-negative blind deconvolution (NNBD) approach to quantify calcium (Ca2+ ) handling, beating force and contractility in human-induced plur
Publikováno v:
ACS Chemical Neuroscience. 12:2810-2819
The main focus of prion structural biology studies is to understand the molecular basis of prion diseases caused by misfolding, and aggregation of the cellular prion protein PrPC remains elusive. Several genetic mutations are linked with human prion
Publikováno v:
FEBS Letters. 595:2071-2084
Human coilin-interacting nuclear ATPase protein (hCINAP), also known as adenylate kinase 6 (AK6), is an atypical adenylate kinase with critical roles in many biological processes, including gene transcription, ribosome synthesis, cell metabolism, cel
Autor:
Hao-Ping Liu, Guan-Ru Liao, Ying-Ping Huang, Ching-Yu Tseng, Yeu-Yang Tseng, Wei-Li Hsu, Ching-Hsiu Tsai
Publikováno v:
FEBS Letters. 595:1721-1733
The OV20.0 virulence factor of orf virus (ORFV) antagonizes host antiviral responses. One mechanism through which it functions is by inhibiting activation of the dsRNA-activated protein kinase R (PKR) by sequestering dsRNA and by physically interacti
Autor:
Tetsuya Hirata, Yi-Shi Liu, Xiao-Dong Gao, Xin-Yu Guo, Morihisa Fujita, Taroh Kinoshita, Jing Yang
Publikováno v:
FEBS Letters. 595:1542-1558
Over 100 glycosylphosphatidylinositol-anchored proteins (GPI-APs) are encoded in the mammalian genome. It is not well understood how these proteins are targeted and translocated to the endoplasmic reticulum (ER). Here, we reveal that many GPI-APs, su
Publikováno v:
Febs Letters
Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (B.1.1.7 and B.1351) have emerged harbouring mutations that make them highly contagious. The N501Y mutation within the receptor-binding domain (RBD) of the spike protein
Publikováno v:
Acta Crystallogr F Struct Biol Commun
AGAP1 is often considered to regulate membrane trafficking, protein transport and actin cytoskeleton dynamics. Recent studies have shown that aberrant expression of AGAP1 is associated with many diseases, including neurodevelopmental disorders and ac
Publikováno v:
FEBS Letters. 595:881-891
Staphylococcus aureus is a major cause of infectious disease. Macrophages can directly destroy most of the invading bacteria through the phagolysosomal pathway. E74-like factor 4 (Elf4) is one of the important transcription factors that controls dive
Autor:
Stefan T. Arold, Audrey Restouin, Yves Collette, Sandrine Opi, Safia Aljedani, Christian Dumas, Mingdong Huang, Luc Ponchon, Xavier Morelli, Umar F. Shahul Hameed, Afaque Ahmad Imtiyaz Momin, Adrien Lugari, Xiaoli Shi, Abdullah Aldehaiman, Luyao Wang
Publikováno v:
'Biochemical Journal ', vol: 478, pages: 1525-1545 (2021)
Biochemical Journal
Biochemical Journal, Portland Press, 2021, 478 (8), pp.1525-1545. ⟨10.1042/bcj20201002⟩
Biochemical Journal, 2021, 478 (8), pp.1525-1545. ⟨10.1042/bcj20201002⟩
Biochemical Journal
Biochemical Journal, Portland Press, 2021, 478 (8), pp.1525-1545. ⟨10.1042/bcj20201002⟩
Biochemical Journal, 2021, 478 (8), pp.1525-1545. ⟨10.1042/bcj20201002⟩
The Nef protein of human and simian immunodeficiency viruses (HIV and SIV, respectively) boosts viral pathogenicity through its interactions with host cell proteins. Nef has a folded core domain and large flexible regions, each carrying several prote