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Autor:
Liang Chen, Xiaojun Yu, Xiang Gao, Zunliang Ke, Wenqu Jiang, Qiwei Huang, Guobin Zhang, Chao Li
Publikováno v:
Biochemical and Biophysical Research Communications. 586:34-41
Molecular biomarkers play an important guidance role in the diagnosis and treatment of glioma. It has been found that TRAM2 (translocation associated membrane protein 2) drives human cancers development. Here we report that TRAM2 activity is required
Autor:
Min Ju Pyo, Sang-Yeob Kim, Ji won Lee, Tae-Keun Kim, Yeonhee Shin, Chan-Gi Pack, You Sook Cho, A.Ryang Lee, Ji Hyang Lee
Publikováno v:
Biochemical and Biophysical Research Communications. 587:42-48
Optical diffraction tomography (ODT), an emerging imaging technique that does not require fluorescent staining, can measure the three-dimensional distribution of the refractive index (RI) of organelles. In this study, we used ODT to characterize the
Autor:
Akira Yamauchi, Keisuke Kitakaze, Shuichiro Okamoto, Kei Miyano, Hitomi Kato, Mizuho Kajikawa, Momoe Itsumi, Chikage Kawai, Futoshi Kuribayashi
Publikováno v:
Biochemical and Biophysical Research Communications. 587:78-84
An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble
Publikováno v:
Biochemical and Biophysical Research Communications. 584:60-65
Current study is intended to evaluate the expression and epigenetic variations of mitochondrial situins in 306 rheumatoid arthritis (RA) cases and compared with age/gender matched controls.The expression level was measured using the quantitative Real
Autor:
Tetsuo Akimoto, Junyan Du, Ryoichi Hirayama, Katsuya Tsuchihara, Yasuhiro Hirano, Shun-ichiro Kageyama, Hidenari Hirata, Masaki Nakamura, Hidehiro Hojo, Masayuki Okumura, Atsushi Motegi, Riu Yamashita
Publikováno v:
Biochemical and Biophysical Research Communications. 585:55-60
Radiotherapy (RT) is an effective treatment option for cancer; however, its efficacy remains less than optimal in locally advanced cancer. Immune checkpoint inhibitor-based therapy, including the administration of anti-PD-L1 antibodies, is a promisin
Autor:
Dhiraj Kumar, Imtaiyaz Hassan
Publikováno v:
Biochemical and Biophysical Research Communications. 585:124-131
Disease models have proven useful tools for gaining deeper mechanistic insights into neurodegenerative diseases. In this context, stem cell technology is effective, especially induced pluripotent stem cell (iPSC)-derived brain organoids and cell repl
Publikováno v:
Biochemical and Biophysical Research Communications. 581:60-67
Background: LncRNA homeobox (HOX) A11 antisense (HOXA11-AS) mediates cell-biological phenotypes of keloid fibroblasts and influence the keloid progression, yet the underlying mechanism is not fully understood.Methods: HOXA11-AS, miR-148b-3p and IGFBP
Autor:
Johanna Zerbib, Daniel Aberdam, Edward Pichinuk, Elie Frank, Léa Zennaro, Keren Oved, Orly Dorot, Lauriane N. Roux, Dominique Bremond-Gignac
Publikováno v:
Biochemical and Biophysical Research Communications. 582:100-104
Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-relat
Autor:
Junyi Zheng, Lei Wu, Per Olof Berggren, Yuqi Liu, Xiaoting Chen, Nanwei Tong, Juan Li, Zhenghao Wang, Ye Zhou, Xiaofeng Zheng, Ge Peng
Publikováno v:
Biochemical and Biophysical Research Communications. 581:110-117
Type 2 diabetes (T2D) is a multifactorial and polygenetic disease, although its exact etiology remains poorly understood. The objective of this study was to identify key biomarkers and potential molecular mechanisms in the development of T2D. Human R
Autor:
Atsushi Hoshino, Shunta Taminishi, Yoshito Minami, Satoaki Matoba, Ryota Urata, Tomohiro Hino, Takashi Nakagawa, Yohei Fushimura, Eri Iwai-Kanai, Satoru Furukawa
Publikováno v:
Biochemical and Biophysical Research Communications. 585:191-195
Impairment of pancreatic β cells is a principal driver of the development of diabetes. Restoring normal insulin release from the β cells depends on the ATP produced by the intracellular mitochondria. In maintaining mitochondrial function, the tumor