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Publikováno v:
Biochemical and Biophysical Research Communications. 558:147-153
Background Our previous study identified elevated expression of the P2X7 receptor (P2X7R) in colorectal cancer (CRC) patients, suggesting the receptor is a target for predicting poor disease prognosis. A438079 is a highly selective P2X7R antagonist,
Autor:
Sara Rosendahl, Rima Sulniute, Julia Persson, Sebastian Forsberg, Rebecka Häggvik, Viktor Drewsen, Cecilia Koskinen Holm, Elin Kindstedt, Pernilla Lundberg
Publikováno v:
Biochemical and biophysical research communications. 620
We recently showed that adult male mice that lacked the C–C-chemokine receptor 3 (CCR3) exhibited disturbed bone remodeling, which resulted in a cortical bone phenotype of thin femoral cortical bone. However, it remains unknown whether this phenoty
Autor:
Yang Zheng, Run Zhang, Xue-Ping Shao, Shi-Jing Mo, Ren-Hua Sun, Jun Hong, Xiang-Hong Yang, Bang-Chuan Hu, Zi-Qiang Shao, Zhi-Dong Chen, Jin-Quan Liu
Publikováno v:
Biochemical and Biophysical Research Communications. 554:158-165
Ascorbate (Vitamin C) has been proposed as a promising therapeutic agent against sepsis in clinical trials, but there is little experimental evidence on its anti-septic efficacy. We report that Toll-like receptor 4 (TLR4) activation by LPS stimuli au
Autor:
Yoshiyuki Iwase, Takamichi Arima, Kanako Miyano, Michiko Narita, Minoru Narita, Yukari Suda, Naoko Kuzumaki, Shigeru Sasaki, Tomohisa Mori, Yusuke Hamada, Kazuyuki Sugita, Kimio Higashiyama, Shoki Matsumura, Yasuhito Uezono, Mitsuaki Yamazaki, Akinobu Matsuzawa, Takayasu Yamauchi, Yoshinori Takemura
Publikováno v:
Biochemical and Biophysical Research Communications. 534:988-994
TRV130 (oliceridine), a G protein-biased ligand for μ-opioid receptor, has recently been synthesized. It is considered to have strong antinociceptive effects and only minor adverse effects. However, whether or not oliceridine actually exhibits an id
Publikováno v:
Biochemical and Biophysical Research Communications. 533:282-288
Dendritic cells (DC) are the most important antigen-presenting cells, which guide T cell activation and function, and dysregulated DC function might be one of the crucial causes of inflammatory bowel disease (IBD). It has been well-known that microbi
Publikováno v:
Biochemical and Biophysical Research Communications. 528:485-492
Alcoholic hepatitis (AH) is an important form of alcoholic liver disease (ALD), and its incidence is continuously increasing leading to advanced disease burden. The NOD-like receptors (NLRs) are a specialized group of intracellular pattern recognitio
Autor:
Hanlin Wang, Yong Dai, Wanxia Cai, Wenxin Zuo, Wen Li, Donge Tang, Hongliang Xie, Jianming Tang, Zhipeng Zeng, Xiaobin Wang, Qian Zhang, Mengmeng Wang
Publikováno v:
Bioscience Reports
Adenoid cystic carcinoma (ACC) is an extremely rare salivary gland tumor with a poor prognosis and needs attention on molecular mechanisms. Protein ubiquitination is an evolutionarily conserved post-translational modification (PTM) for substrates deg
Publikováno v:
Bioscience Reports
The analysis of the urine contents can be informative of physiological homoeostasis, and it has been speculated that the levels of urinary d-serine (d-ser) could inform about neurological and renal disorders. By analysing the levels of urinary d-ser
Autor:
Sarah Aldhafiri, K. Thornton, Des C. Winter, Eoin P. Cummins, Brenda Murphy, Mohamed Ismaiel, Hugh E. Giffney, Anindya Mukhopadhya, Sarinj Fattah, Ciara E. Keogh, Helen Mohan, Daniel Crean, Evelyn P. Murphy
Publikováno v:
Biochemical and biophysical research communications. 554
Inflammation is a pivotal pathological factor in colorectal cancer (CRC) initiation and progression, and modulating this inflammatory state has the potential to ameliorate disease progression. NR4A receptors have emerged as key regulators of inflamma
Autor:
Bo-Wen Hu, Wang Zhihui, Wen Peihao, Shuijun Zhang, Wenzhi Guo, Dongjing Yang, Zhong-Kun Huo, Zexin Li
Publikováno v:
Biochemical and biophysical research communications. 552
Hepatocyte apoptosis is a crucial factor affecting liver quality in brain-dead donors. The identification of key molecular proteins involved in brain-death (BD)-induced hepatocyte apoptosis may help determine an effective method for improving the qua