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Autor:
Wansoo Kim, Dong-Yeop Yeo, Seong-Kyoon Choi, Hee-Yeon Kim, Seoung-Woo Lee, Janbolat Ashim, Jee Eun Han, Wookyung Yu, Hyohoon Jeong, Jin-Kyu Park, Song Park
Publikováno v:
Biochemical and Biophysical Research Communications. 635:99-107
Although several studies have focused on cancer diagnosis and therapy, prostate cancer (PC) remains an intractable disease. Androgen deprivation therapy (ADT), which is used to treat early stage PC can lead to the development of castration-resistant
Autor:
Ikue Sekai, Kosuke Minaga, Akane Hara, Yasuo Otsuka, Masayuki Kurimoto, Naoya Omaru, Natsuki Okai, Yasuhiro Masuta, Ryutaro Takada, Tomoe Yoshikawa, Ken Kamata, Masatoshi Kudo, Tomohiro Watanabe
Publikováno v:
Biochemical and Biophysical Research Communications. 637:189-195
Autoimmune pancreatitis (AIP) is an autoimmune disorder of the pancreas characterized by enhanced IgG4 antibody responses and multiple organ involvement. AIP is a pancreatic manifestation of the systemic IgG4-related disease (IgG4-RD). Although AIP a
Autor:
Jong-Tae Kim, Tae Yeon Kim, Dong Hyuk Youn, Sung Woo Han, Chan Hum Park, Younghyurk Lee, Harry Jung, Jong Kook Rhim, Jeong Jin Park, Jun Hyong Ahn, Heung Cheol Kim, Sung Min Cho, Jin Pyeong Jeon
Publikováno v:
Biochemical and Biophysical Research Communications. 635:169-178
There are no effective treatments for relieving neuronal dysfunction after mild traumatic brain injury (TBI). Here, we evaluated therapeutic efficacy of human embryonic stem cell-derived cerebral organoids (hCOs) in a mild TBI model, in terms of repa
Publikováno v:
Biochemical and Biophysical Research Communications. 631:25-31
Cancer stem cells (CSCs) are a subpopulation that can drive recurrence and metastasis. Therefore, therapies targeting CSCs are required. Although previous findings have suggested that non-CSCs regulate the proliferation and differentiation of CSCs in
Autor:
Nadezhda G. Gumanova, Dmitry K. Vasilyev, Natalya L. Bogdanova, Yaroslav I. Havrichenko, Alexander Ya Kots, Victoria A. Metelskaya
Publikováno v:
Biochemical and Biophysical Research Communications. 631:55-63
Protein expression profiling in the serum is used to identify novel biomarkers and investigate the signaling pathways in various diseases. The aim of the present study was to evaluate serum biomarkers associated with coronary artery stenosis resultin
Autor:
Dahwan Lim, Sein Jin, Ho-Chul Shin, Wantae Kim, Joon Sig Choi, Doo-Byoung Oh, Seung Jun Kim, Jinho Seo, Bonsu Ku
Publikováno v:
Biochemical and Biophysical Research Communications. 625:174-180
Antiapoptotic B-cell lymphoma-2 (Bcl-2) proteins suppress apoptosis by interacting with proapoptotic regulators. They commonly contain a hydrophobic groove where the Bcl-2 homology 3 (BH3) domain of Bcl-2 family members or BH3 domain-containing non-B
Publikováno v:
Biochemical and Biophysical Research Communications. 620:35-41
Circular RNAs (circRNAs) have been proved could regulate many cancers, including prostate cancer (PCa). In this paper, we reconnoitered the roles of circRNA pyruvate dehydrogenase complex component X (circPDHX) in PCa.The circPDHX, microRNA (miR)-497
Autor:
Ying Li, Li Wan, Lili Zhang, Zhongling Zhuo, Xuanmei Luo, Jingyi Cui, Ye Liu, Fei Su, Min Tang, Fei Xiao
Publikováno v:
Biochemical and Biophysical Research Communications. 621:67-73
Nonsense-mediated mRNA decay (NMD) and its regulation play an important role in eliminating faulty transcripts and controlling gene expression. However, measuring NMD activity and characterizing its targets remain challenging. In this study, we set o
Publikováno v:
Biochemical and Biophysical Research Communications. 616:104-109
Dosage compensation is a process that produces a similar expression of sex-linked and autosomal genes. In the silkworm Bombyx mori with a WZ sex-determination system, the expression from the single Z in WZ females matches that of ZZ males due to the
Publikováno v:
Biochemical and Biophysical Research Communications. 617:33-40
Programmed death-ligand 1 (PD-L1), a critical immune checkpoint ligand, is commonly overexpressed on the surface of many tumor types including lung and prostate cancer. PD-L1 can exert cancer-promoting activity through either suppressing T cell-media