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Publikováno v:
Biochemical and Biophysical Research Communications. 584:60-65
Current study is intended to evaluate the expression and epigenetic variations of mitochondrial situins in 306 rheumatoid arthritis (RA) cases and compared with age/gender matched controls.The expression level was measured using the quantitative Real
Publikováno v:
Biochemical and Biophysical Research Communications. 585:132-138
Dexamethasone (DEX) is a synthetic glucocorticoid with anti-inflammatory properties. We evaluated a potentially protective dexamethasone influence on hepatocellular lipid metabolism and fatty acid (FA) transporters expression. The HepG2 cells were in
Autor:
Atsushi Hoshino, Shunta Taminishi, Yoshito Minami, Satoaki Matoba, Ryota Urata, Tomohiro Hino, Takashi Nakagawa, Yohei Fushimura, Eri Iwai-Kanai, Satoru Furukawa
Publikováno v:
Biochemical and Biophysical Research Communications. 585:191-195
Impairment of pancreatic β cells is a principal driver of the development of diabetes. Restoring normal insulin release from the β cells depends on the ATP produced by the intracellular mitochondria. In maintaining mitochondrial function, the tumor
Publikováno v:
Biochemical and Biophysical Research Communications. 580:1-6
Sphingosine kinase 2 (SphK2) inhibitors are developed for tumor therapy as considering its anti-tumor effect. Many studies also explored SphK2 modulated glucose and lipid homeostasis, which extended its potential function for metabolic diseases thera
Autor:
Guo-Bin Huang, Xinhai Zhu, Xiao-Hong Ma, Huan Ma, Qian Bi, Hong-Mei Jiang, Xihui Gan, Si-Yu Chen, Yong-Cong Shao, Silin Li, Hui-Ying Yang, Jinhu Guo, Ye-Bing Yang
Publikováno v:
Biochemical and Biophysical Research Communications. 567:9-16
The circadian clock plays a critical role in synchronizing the inner molecular, metabolic and physiological processes to environmental cues that cycle with a period of 24 h. Non-24 h and shift schedules are commonly used in maritime operations, and b
Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma
Autor:
Masaru Kumagai, Shunsuke Nojiri, Atsunori Tsuchiya, Shuji Terai, Satoko Motegi, Takeki Sato, Suguru Takeuchi, Takashi Owaki, Yusuke Watanabe, Takahiro Iwasawa, Masahiro Ogawa, Yuzo Kawata, Hiroteru Kamimura
Publikováno v:
Biochemical and Biophysical Research Communications. 566:36-44
The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect of both NASH and IBD on hepatocellular carcinoma (HCC) using a mouse model combining NASH and IBD. T
Autor:
Arisa Ochi, Yasumasa Ikeda, Naoki Kashihara, Kojiro Nagai, Kensei Taguchi, Masanori Tamaki, Ken-ichi Aihara, Hideharu Abe, Masashi Miyoshi, Craig R. Brooks, Hiroyuki Kadoya, Kenji Nishimura, Seiji Kishi
Publikováno v:
Biochemical and Biophysical Research Communications. 556:142-148
The relationship between cellular senescence and fibrosis in the kidney is being elucidated and we have identified it as therapeutic target in recent studies. Chronic kidney disease has also become a lifestyle disease, often developing on the backgro
Autor:
Wei Wang, Chen Xing, Min Zhang, Yifan Zhang, Lun Song, Mengnan Ding, Beifen Shen, Lin Wu, Chongchong Zhang, Chunfeng Lu, Xin Huang, Yu Gu
Publikováno v:
Biochemical and Biophysical Research Communications. 559:217-221
Ornithine transcarbamylases (OTC), a key enzyme in urea cycle, is an important marker for some liver injury or diseases. However, whether OTC could be a sensitive indicator for liver dysfunction under sleep disturbance condition remains unknown. The
Publikováno v:
Biochemical and Biophysical Research Communications. 555:54-60
Non-alcoholic fatty liver disease (NAFLD) is the pathological manifestation of metabolic syndrome in liver. Its pathological changes may evolve from the initial simple steatosis to non-alcoholic steatohepatitis, liver fibrosis and even liver cancer.
Publikováno v:
Biochemical and Biophysical Research Communications. 553:1-8
Background and aims Hypercholesterolemia is characterized by the elevation of plasma total cholesterol level, especially low-density lipoprotein (LDL) cholesterol. This disease is usually caused by a mutation in genes such as LDL receptor, apolipopro