Zobrazeno 1 - 10
of 557
pro vyhledávání: ''
Autor:
Jiarui Wang, Xianqin Zhang, Tingting Zou, Dazhi Zhang, Wenqiang Liu, Zhenxing Liu, Xuejie Peng, Zhengyi Ni, Yang Tan, Meiqi Hou, Mi Zhou, Chao Yuan, Xiaopei Zhou
Publikováno v:
Biochemical and Biophysical Research Communications. 591:124-129
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare monogenetic disease, which is characterized by susceptibility to some weakly virulent mycobacteria. Here, we explored the pathogenic genes and molecular mechanisms of MSMD patients. W
Publikováno v:
Biochemical and Biophysical Research Communications. 569:106-111
ALS2, a product of the causative gene for familial amyotrophic lateral sclerosis (ALS) type 2, plays a pivotal role in the regulation of endosome dynamics by activating small GTPase Rab5 via its intrinsic guanine nucleotide-exchange factor activity.
Publikováno v:
FEBS Letters. 595:1933-1948
Activated and promoter-bound heat-shock transcription factor 1 (HSF1) induces RNA polymerase II recruitment upon heat shock, and this is facilitated by the core Mediator in Drosophila and yeast. Another Mediator module, CDK8 kinase module (CKM), cons
Autor:
Yuki Shimizu, Akihiko Tsuji, Shogo Abe, Maki Shimada, Mika Nishida, Kenji Miyamoto, Keizo Yuasa
Publikováno v:
Biochemical and Biophysical Research Communications. 552:9-16
Although natriuretic peptide receptor-C (NPR-C) is involved in the clearance of natriuretic peptides from plasma, it also possesses other physiological functions, such as inhibition of adenylyl cyclase activity through Gαi. However, the physiologica
Autor:
David G. McEwan, Georg Tascher, Doris Popovic, Andrea Gubas, Daniela S. Krause, Nina Dawe, Marina E. Hoffmann, Ivan Dikic, Christina Karantanou, Anna Platzek
Publikováno v:
FEBS Letters. 595:864-880
The lysosome is a cellular signalling hub at the point of convergence of endocytic and autophagic pathways, where the contents are degraded and recycled. Pleckstrin homology domain-containing family member 1 (PLEKHM1) acts as an adaptor to facilitate
Publikováno v:
Journal of Cellular and Molecular Medicine
Excitatory amino acid transporter 2 (EAAT2), the gene of which is known as solute carrier family 1 member 2 (SLC1A2), is an important membrane‐bound transporter that mediates approximately 90% of the transport and clearance of l‐glutamate at syna
Autor:
Cheng Jhong Fan, Su Qin Liu, Hsien-Bin Huang, Hui chun Yu, Ning-Sheng Lai, Hsien Yu Huang Tseng, Lu Mc, Bi Yao Jhuang, Yu Shan Lin, Ta Hsien Lin, Kuang Yung Huang
Publikováno v:
Biochemical and Biophysical Research Communications. 531:236-241
Phostensin (PTS) encoded by KIAA1949 is a protein phosphatase 1 (PP1)-binding protein. In order to explore the cellular functions of PTS, we have searched PTS-binding proteins by using co-immunoprecipitation in combination with shotgun proteomics. He
Autor:
Andreas R. Bausch, Andrew R. Harris, Pamela Jreij, Kathy Y. Wei, Brian Belardi, Hengameh Shams, Daniel A. Fletcher
Publikováno v:
Molecular biology of the cell, vol 30, iss 26
Molecular Biology of the Cell
Molecular Biology of the Cell
Tandem calponin homology domains are common actin-binding motifs found in proteins such as α-actinin, filamin, utrophin, and dystrophin that organize actin filaments into functional structures. Despite a conserved structural fold and regions of high
Autor:
Priyanka Madhu, Samrat Mukhopadhyay
Publikováno v:
ACS Chemical Neuroscience. 11:86-98
Soluble oligomeric species of the amyloid-β (Aβ) peptide exhibit pronounced neurotoxic effects in Alzheimer's disease. Recent studies have indicated that the prion protein (PrP) is one of the cell-surface receptors, so-called a bad receptor, of Aβ
Autor:
John F. Presley, Selma Yilmaz Dejgaard
Publikováno v:
Biochemical and Biophysical Research Communications. 520:526-531
Rab18 is a small GTPase associated with lipid droplets and other membranes. While it likely has multiple functions on lipid droplets, one proposed function is regulation of lipolysis. Previous work has concentrated on regulation of autophagy; however