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Autor:
Jiarui Wang, Xianqin Zhang, Tingting Zou, Dazhi Zhang, Wenqiang Liu, Zhenxing Liu, Xuejie Peng, Zhengyi Ni, Yang Tan, Meiqi Hou, Mi Zhou, Chao Yuan, Xiaopei Zhou
Publikováno v:
Biochemical and Biophysical Research Communications. 591:124-129
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare monogenetic disease, which is characterized by susceptibility to some weakly virulent mycobacteria. Here, we explored the pathogenic genes and molecular mechanisms of MSMD patients. W
Publikováno v:
The FEBS Journal. 289:3163-3182
Cellular senescence is protective against external oncogenic stress, but its accumulation causes aging-related diseases. Forkhead box O4 (FOXO4) and p53 are human transcription factors known to promote senescence by interacting each other and activat
Publikováno v:
Biochemical and Biophysical Research Communications. 586:1-7
Sulfation is an essential modification on biomolecules in living cells, and 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) is its unique and universal sulfate donor. Human PAPS synthases (PAPSS1 and 2) are the only enzymes that catalyze PAPS production
Autor:
Fumio Sakane, Fumi Hoshino
Publikováno v:
Biochemical and Biophysical Research Communications
The clathrin coat assembly protein AP180 drives endocytosis, which is crucial for numerous physiological events, such as the internalization and recycling of receptors, uptake of neurotransmitters and entry of viruses, including SARS-CoV-2, by intera
Autor:
Chan Yoon Park, Han Choe, Donguk Kim, Ji-Hoon Jeong, Sung Nim Han, Kyung-Chul Choi, Jimin Kim, Yeon Jin Jang, Hye Soon Park, Seul Ki Lee
Publikováno v:
Biochemical and Biophysical Research Communications. 585:169-176
Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity, insulin resistance, and endoplasmic reticulum (ER) stress. Elevated circulating levels of the hepatokine leukocyte cell-derived chemotaxin-2 (LECT2) have also been noted
Publikováno v:
Biochemical and Biophysical Research Communications. 585:15-21
NMDAR (N-methyl-d-aspartate receptor) consisted of GluN1 and GluN2, and/or GluN3 subunits. As the obligatory subunit of NMDAR, GluN1 contains variant N-terminal domain (NTD) and C-terminal domain (CTD). The CTD contains allosteric signal and mediates
Autor:
Taizo Taniguchi, Kouki Susa, Toshimasa Ishida, Tomohiro Tsuchida, Yasuko In, Koji Tomoo, Tomohiro Kibiki, Takahiro Tsuchiya, Katsuhiko Minoura, Katsushiro Miyamoto
Publikováno v:
Biochemical and Biophysical Research Communications. 585:36-41
One of the histopathological features of Alzheimer's disease (AD) is higher order neurofibrillary tangles formed by abnormally aggregated tau protein. The sequence 275VQIINK280 in the microtubule-binding domain of tau plays a key role in tau aggregat
Publikováno v:
Febs Letters
The current work investigated SARS‐CoV‐2 Nucleocapsid (NCAP or N protein) interactors in A549 human lung cancer cells using a SILAC‐based mass spectrometry approach. NCAP interactors included proteins of the stress granule (SG) machinery and im
Publikováno v:
FEBS Letters
Pellino-2 is an E3 ubiquitin ligase that mediates intracellular signaling in innate immune pathways. Most studies of endogenous Pellino-2 have been performed in macrophages, but none in nonimmune cells. Using yeast two-hybrid screening and co-immunop
Publikováno v:
Biochemical and Biophysical Research Communications. 577:80-88
Atherosclerosis still remains the leading cause of morbidity and mortality worldwide, and deeper understanding of target signaling that protect from the atherosclerosis progression may provide novel therapeutic strategies. CDGSH iron-sulfur domain-co