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Autor:
Tasuku Nishino, Takaya Abe, Mari Kaneko, Masanao Yokohira, Keiko Yamakawa, Katsumi Imaida, Hiroaki Konishi
Publikováno v:
Biochemical and Biophysical Research Communications. 628:91-97
The adaptor protein GAREM has two subtypes. Each is involved in Erk activation signaling downstream of the cell growth factor receptor in cultured cells. Regarding their role in individual animals, we have previously reported that mice deficient in G
Autor:
Yaping Chen, Xiaofei Zhang
Publikováno v:
Biochemical and Biophysical Research Communications. 625:23-30
TRAF-binding domain-containing protein (TRABID), a member of the OTU deubiquitinase family, has an important role in regulating cellular functions via deubiquitinating substrate proteins such as EZH2 and Jmjd2d. However, the mechanism of its role in
Publikováno v:
Biochemical and Biophysical Research Communications. 622:1-7
Cancer development comprehends changes in cell structural and physical states. Cancer cells are softer than normal cells, produce higher contractile forces, and migrate more easily. While chemotherapy, targets proteins involved in biological behavior
Publikováno v:
Biochemical and Biophysical Research Communications. 596:56-62
Despite the success of proteasome inhibitors (PIs) in treating hematopoietic malignancies, including multiple myeloma (MM), their clinical efficacy is limited in solid tumors. In this study, we investigated the involvement of the integrated stress re
Autor:
Candy M. Rivas, Hillary V. Schiff, Aubin Moutal, Rajesh Khanna, Pawel R. Kiela, Gregory Dussor, Theodore J. Price, Josef Vagner, Kathryn A. DeFea, Scott Boitano
Publikováno v:
Biochem Biophys Res Commun
Inhalation of the fungus Alternaria alternata is associated with an increased risk of allergic asthma development and exacerbations. Recent work in acute exposure animal models suggests that A. alternata-induced asthma symptoms, which include inflamm
Autor:
Seung Min Baek, Kyung Won Kim, EUN GYUL KIM, Min Jung Kim, Ji Su Leem, Myung Hyun Sohn, JAEWOO LEE, Mi Na Kim
Publikováno v:
Biochemical and Biophysical Research Communications. 592:106-112
Viral respiratory infection causes inflammatory lung disease. Chitinase 3-like 1 (CHI3L1) contributes to airway inflammation, but its role in human airway epithelial cells following viral infection is unclear. Thus, we investigated whether CHI3L1 reg
Publikováno v:
The Journal of Membrane Biology. 255:261-276
The volume-activated chloride channel (VACC) serves vital cellular functions in secretion and cell volume regulation via regulatory volume decrease (RVD) in various epithelia. Previously, we have shown that RVD in primary CF mouse cholangiocytes is i
Autor:
Anh Thi Ngoc Bui, Hyojin Son, Seulki Park, Sohee Oh, Jin-Sik Kim, Jin Hwa Cho, Hye-Jin Hwang, Jeong-Hoon Kim, Gwan-Su Yi, Seung-Wook Chi
Publikováno v:
Biochemical and Biophysical Research Communications. 588:97-103
Apoptosis plays an essential role in maintaining cellular homeostasis and preventing cancer progression. Bcl-xL, an anti-apoptotic protein, is an important modulator of the mitochondrial apoptosis pathway and is a promising target for anticancer ther
Autor:
Fumio Sakane, Fumi Hoshino
Publikováno v:
Biochemical and Biophysical Research Communications
The clathrin coat assembly protein AP180 drives endocytosis, which is crucial for numerous physiological events, such as the internalization and recycling of receptors, uptake of neurotransmitters and entry of viruses, including SARS-CoV-2, by intera
Publikováno v:
Biochemical and Biophysical Research Communications. 590:55-62
Cellular senescence is a state of irreversible cell growth arrest that functions as a biological defense mechanism against severe DNA damage. Senescent cells with DNA damage produce pro-inflammatory cytokines, such as IL-6 and IL-8, and this phenomen