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Autor:
Akira Yamauchi, Keisuke Kitakaze, Shuichiro Okamoto, Kei Miyano, Hitomi Kato, Mizuho Kajikawa, Momoe Itsumi, Chikage Kawai, Futoshi Kuribayashi
Publikováno v:
Biochemical and Biophysical Research Communications. 587:78-84
An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble
Autor:
Johanna Zerbib, Daniel Aberdam, Edward Pichinuk, Elie Frank, Léa Zennaro, Keren Oved, Orly Dorot, Lauriane N. Roux, Dominique Bremond-Gignac
Publikováno v:
Biochemical and Biophysical Research Communications. 582:100-104
Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-relat
Autor:
Kuniko Katagiri, Miku Ishizawa, Mari Kannagi, Yoshiko Nagano, Nobuyo Kondo, Atsuhiko Hasegawa, Takeru Yoneda, Takao Masuda
Publikováno v:
Biochemical and Biophysical Research Communications. 574:104-109
Immunomodulatory imide drugs (IMiDs), such as lenalidomide and pomalidomide, exert pleiotropic effects, e.g., antitumor effects in multiple myeloma, by binding the protein Cereblon and altering its substrate specificity. Lenalidomide is approved for
Autor:
Elias Georges, Georgia Limniatis
Publikováno v:
Biochemical and Biophysical Research Communications. 570:148-153
P-glycoprotein, member of the B-subfamily of the ATP-binding cassette (ABC) superfamily (e.g., ABCB1), has been demonstrated to confer resistance to clinically relevant anticancer drugs. Paradoxically, ABCB1-expressing multidrug resistant (MDR) cells
Publikováno v:
Biochemical and Biophysical Research Communications. 567:56-62
Human circadian rhythm refers to the intrinsic ∼24-h oscillation that regulates biological processes to adapt to environments. Disruption of rhythmicity causes mitochondrial dysfunction, changes metabolism, and is associated with neurodegenerative
Autor:
Huiqing Hu, Mengmeng Yang, Lei Sun, Yixin Cui, Qin He, Li Chen, Chuan Wang, Jia Song, Lingshu Wang, Xinghong Guo, Nan Zang, Chen Cui, Sha Sha, Kai Liang
Publikováno v:
Biochemical and Biophysical Research Communications. 546:74-82
Non-alcoholic fatty liver disease (NAFLD), an emerging risk factor for diabetes, is now recognized as the most common liver disease worldwide. Mesenchymal stem cells (MSCs), a promising tool in regenerative medicine, release abundant molecules into t
Autor:
Emiko Sato, Yuji Oe, Daisuke Saigusa, Hiroshi Sato, Ritsumi Saito, Sadayoshi Ito, Yoshiko Kawana, Akiyo Sekimoto, Nobuyuki Takahashi, Manami Kaneko, Yukako Tsunokuni, Shuichi Shimma
Publikováno v:
Biochemical and Biophysical Research Communications. 527:1064-1071
Preeclampsia (PE) is a leading cause of maternal morbidity and mortality. Nicotinamide has beneficial effects on PE. In this study, we evaluated the effect of nicotinamide on placental development using a PE mouse model. To generate the PE model, a r
Publikováno v:
Biochemical and Biophysical Research Communications. 527:751-756
Inflammation is provoked by host immune reactions to pathogenic or tissue injury and is arbitrated by cytokines. Among the pro-inflammatory cytokines, the tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) are main mediators of inflammati
Publikováno v:
Biochemical and Biophysical Research Communications. 527:242-249
Intratumoral heterogeneity remains as a major challenge in the treatment resistance of prostate cancer. Understanding the mechanism of prostate cancer heterogeneity is essential for developing effective therapies. In this study, we reported the heter
Autor:
Masako Kiyono, Yuka Ohshiro, Yasukazu Takanezawa, Tomoya Kusaka, Shimpei Uraguchi, Ryosuke Nakamura
Publikováno v:
Biochemical and Biophysical Research Communications. 526:206-212
Gadolinium-based contrast agents (GBCAs) are widely used in clinical magnetic resonance imaging (MRI). Free gadolinium ions (Gd3+) released from GBCAs potentially increase the risk of GBCA-related toxicity. However, the cellular responses to Gd3+ and