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Publikováno v:
Biochemical Journal. 478:3977-3998
Tunneling nanotubes (TNTs) are F-actin-based, membrane-enclosed tubular connections between animal cells that transport a variety of cellular cargo. Over the last 15 years since their discovery, TNTs have come to be recognized as key players in norma
Autor:
Carmen Höglinger, Marc Fahrner, Isabella Derler, Herwig Grabmayr, Martin Muik, Heinrich Krobath, Lena Maltan, Christoph Romanin, Ferdinand Horvath, Adéla Tiffner, Thomas Renger
Publikováno v:
Cellular and Molecular Life Sciences
The calcium release-activated calcium (CRAC) channel consists of STIM1, a Ca2+ sensor in the endoplasmic reticulum (ER), and Orai1, the Ca2+ ion channel in the plasma membrane. Ca2+ store depletion triggers conformational changes and oligomerization
Publikováno v:
Acta Biochimica et Biophysica Sinica. 52:1093-1101
Previously, Nucleolar protein 66 (NO66) was reported to be closely associated with alcohol exposure-induced injury. However, the role of NO66 in alcohol-induced cytotoxicity remains unclear. In this study, we explored the potential effect and mechani
Publikováno v:
Biochem Biophys Res Commun
High levels of reactive oxygen species such as hydrogen peroxide (H(2)O(2)) cause oxidative stress in the lens and lead to cataractogenesis. The present investigation was undertaken to find out whether the mammalian lens aquaporins (AQPs) 0, 1, and 5
Autor:
Robert K. Ernst, Robert S. Chapkin, Jessica L. Symons, Kandice R. Levental, Ilya Levental, Yang Yi Fan, Eric Malmberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Proper membrane physiology requires maintenance of biophysical properties, which must be buffered from external perturbations. While homeostatic adaptation of membrane fluidity to temperature variation is a ubiquitous feature of ectothermic organisms
Autor:
Thomas A. Kwiatkowski, Aubrey L. Rose, Rosalie Yan, Noah Weisleder, Diana Hallak, Ana Capati, Rachel Jung
Publikováno v:
Am J Physiol Cell Physiol
Various previous studies established that the amphiphilic tri-block copolymer known as poloxamer 188 (P188) or Pluronic-F68 can stabilize the plasma membrane following a variety of injuries to multiple mammalian cell types. This characteristic led to
Autor:
Tatsuro Irimura, Kyohei Higashi, Yurina Tani, Momoko Isono, Motowo Nakajima, Shoichi Onishi, Nakaba Sesoko, Rino Maeda, Nobuaki Higashi, Katsuhiko Takahashi, Sodai Ishikawa, Teruaki Oku
Publikováno v:
Biochemical and Biophysical Research Communications. 520:152-158
We examined whether chondroitin sulfates (CSs) exert inhibitory effects on heparanase (Hpse), the sole endoglycosidase that cleaves heparan sulfate (HS) and heparin, which also stimulates chemokine production. Hpse-mediated degradation of HS was supp
Publikováno v:
Biochemical and Biophysical Research Communications. 520:166-170
Raised brain levels of testosterone (Tes), as well as single nucleotide polymorphisms of P-glycoprotein (P-gp) that cause impaired transport function, are associated with increased risk of suicide. Here, we examined whether Tes and its precursors and
Autor:
Jeremy C. Simpson, Margaritha M Mysior
Publikováno v:
Bioscience Reports
The endomembrane system of mammalian cells provides massive capacity for the segregation of biochemical reactions into discrete locations. The individual organelles of the endomembrane system also require the ability to precisely transport material b
Autor:
Aleksander Czogalla, Dominik Drabik, Krzysztof Grzymajło, Paulina Olszewska, Aleksander F. Sikorski, Agnieszka Biernatowska, Sebastian Kraszewski
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Flotillins are the major structural proteins in erythroid raft domains. We have shown previously that the dynamic nanoscale organization of raft domains in erythroid cells may depend on flotillin-MPP1 interactions. Here, by using molecular dynamic si