Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yutaka Yoshikawa"'
Publikováno v:
Biological Trace Element Research. 192:206-213
The risk of serious complication gradually increases as diabetes mellitus (DM) progresses. Thus, strategies for the prevention and delay of symptom progression are urgently needed. Previously, we synthesized zinc (Zn) complexes estimated to have a hi
Autor:
Keita Chikamoto, Asuka Uratani, Yutaka Yoshikawa, Hiroyuki Yasui, Namika Miya, Yuki Naito, Keiji Terao
Publikováno v:
Journal of clinical biochemistry and nutrition. 66(2)
In the present study, we investigated the effects of exercise intended to prevent or treat lifestyle-related diseases on the glucose tolerance, insulin level, lactic acid utilization, muscle glycogen synthesis, hepatic and renal oxidative stress, hep
Autor:
Kengo Sasaki, Naoko Ikuta, Yutaka Yoshikawa, Gerald Rimbach, Takahiro Furune, Hinako Okamoto, Keiji Terao, Nanako Nihei
Publikováno v:
BioFactors. 44:336-347
We investigated the effect of α-cyclodextrin (α-CD) on the bacterial populations of gut microbiota, production of organic acids, and short-chain fatty acids (SCFAs), and lipid metabolism in obese mice induced by feeding a high-fat diet (HFD). Male
Autor:
Hirotaka Nagai, Norihiko Kohyama, Seishiro Hirano, Li Jiang, Shinya Toyokuni, Hiroyuki Yasui, Yoriko Yamashita, Yasumasa Okazaki, Katsuya Ikuta, Yasushi Shinohara, Hiroki Ohara, Takashi Takahashi, Shinya Akatsuka, Yutaka Yoshikawa, Katsunori Sasaki, Yutaka Kohgo, Shan-Hwu Chew
Publikováno v:
The Journal of Pathology. 228:366-377
Exposure to asbestos is a risk for malignant mesothelioma (MM) in humans. Among the commercially used types of asbestos (chrysotile, crocidolite, and amosite), the carcinogenicity of chrysotile is not fully appreciated. Here, we show that all three a
Autor:
Samer Al Said, Mihály Ruppert, Hiroyuki Yasui, Shiliang Li, Sevil Korkmaz-Icöz, Matthias Karck, Patrick Most, Niels Grabe, Maik Brune, Ayhan Atmanli, Paige Brlecic, Lorenz H. Lehmann, Bernd Lahrmann, Péter Hegedűs, Yutaka Yoshikawa, Tamás Radovits, Gábor Szabó
Publikováno v:
Cardiovascular Diabetology
Background: Type-2 diabetics have an increased risk of cardiomyopathy, and heart failure is a major cause of death among these patients. Growing evidence indicates that proinflammatory cytokines may induce the development of insulin resistance, and t
Publikováno v:
Bulletin of the Chemical Society of Japan. 84:298-305
Zinc complexes exhibi th igh insulin-like and antidiabetic activities i na nimal sw ith type 2 diabetes mellitus (DM). However, molecular mechanisms underlying these activities have not yet been determined. In this study, we investigated activation o
Autor:
Hiroyuki Yasui, Ayhan Atmanli, Shiliang Li, Sevil Korkmaz-Icöz, Yutaka Yoshikawa, Matthias Karck, Paige Brlecic, Mihály Ruppert, Peter Hegedüs, Gábor Szabó, Tamás Radovits
Publikováno v:
The journal of physiological sciences : JPS. 66(2)
We recently demonstrated that the pre-treatment of rats with zinc and acetylsalicylic acid complex in the form of bis(aspirinato)zinc(II) [Zn(ASA)2] is superior to acetylsalicylic acid in protecting the heart from acute myocardial ischemia. Herein, w
Publikováno v:
Life Sciences. 78:2860-2866
Vanadyl(IV) ions (+ 4 oxidation state of vanadium) and their complexes have been shown to have in vitro insulinomimetic activity and to be effective in treating animals with diabetes mellitus. Although, researchers have proposed many vanadyl compound
Publikováno v:
Life Sciences. 75:741-751
Zinc (Zn), an essential trace element, and its complexes have recently been known to exhibit insulinomimetic activities. However, the action mechanism of Zn(II) has yet been obscure. The purpose of the present study was to estimate the action mechani
Autor:
Harald Schmidt, Yutaka Yoshikawa, Sevil Korkmaz, Hiroyuki Yasui, Shiliang Li, Matthias Karck, Béla Merkely, Gábor Szabó, Péter Hegedűs, Tamás Radovits
Publikováno v:
Cardiovascular drugs and therapy. 28(6)
Neointima formation following angioplasty is a serious consequence of endothelial damage in arteries. Inflammatory mediators and lack of endothelial regulatory mechanisms lead to migration and proliferation of smooth-muscle cells and thus to restenos