Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Xiaoyu Zhang"'
Autor:
Xingyuan Xu, Mao Ye, Xiaoyu Zhang, Long-Yun Ye, Shanshan Li, Hang Shen, Qi Zhang, Tingbo Liang
Publikováno v:
Hepatology (Baltimore, Md.)
Background and aims Due to their inherent characteristics, the function of group-2 innate lymphoid cells (ILC2s) varies in a context-dependent manner. ILC2s are involved in certain liver diseases; however, their involvement in HCC is unknown. In the
Publikováno v:
Inflammopharmacology. 29:1487-1501
Alpha-7 nicotinic acetylcholine receptor (α7 nAChR) was reported to have a critical role in the regulation of pain sensitivity and neuroinflammation. However, the expression level of α7 nAChR in dorsal root ganglion (DRG) and the underlying neuroin
Autor:
Zeda Zhao, Mingyao Liu, Zhen Zhang, Wenxiang Zhao, Xiaoyu Zhang, Bing Du, Zhangsheng Lv, Min Qian, Qin Wang, Yihan Zhao, Juliang Qin, Hua Ren
Publikováno v:
Science China Life Sciences. 65:953-968
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints and is associated with excessive immune cell infiltration. However, the complex interactions between the immune cell populations in the RA synovium remain unk
Autor:
Xiaoyu Zhang, Zeping Zhou, Jun Peng, Shuwen Wang, Shaoqiu Leng, Yanqi Zhang, Ju Li, Qi Feng, Xiang Hu
Publikováno v:
Annals of Hematology. 100:2453-2462
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by decreased platelet count. While corticosteroids are a useful first-line therapy for ITP patients, their long-term effectiveness is limited, and the determinants of corti
Publikováno v:
Journal of Cellular and Molecular Medicine
Previous studies have shown that dexamethasone (Dex) reduces the levels of anti-nuclear (ANA) and anti-dsDNA antibodies in MRL/lpr mice (a mouse model of SLE). However, the effect of Dex on T follicular helper (Tfh) cells is less documented. Here, us
Autor:
Kristen A. Baltgalvis, Vincent M. Crowley, Michael A. Schafroth, Brian E. Nordin, Benjamin F. Cravatt, Christie L Eissler, Joe L Rodriguez, Shota Kikuchi, Xiaoyu Zhang, Thomas G Wucherpfennig, Todd Kinsella, Kent T Symons, Melissa M. Dix, David S. Weinstein, Dean Stamos, Gabriel M. Simon, Yu Yamashita, Ludwig Bauer, Lena M Luukkonen
Publikováno v:
J Am Chem Soc
Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligases have bee
Publikováno v:
Biochemistry
DCAF16 is a substrate recognition component of Cullin-RING E3 ubiquitin ligases that can be targeted by electrophilic PROTACs (proteolysis targeting chimeras) to promote the nuclear-restricted degradation of proteins. The endogenous protein substates
Autor:
Dong Li, Youxin Wang, Wei Wang, Xizhu Xu, Sun Baoliang, Haifeng Hou, Hui Yuan, Jie Zhang, Xiaoyu Zhang, Jihui Lyu, Jing Su, Xiaoni Meng, Qiuyue Tian, Yuejin Li
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-12 (2021)
NPJ Aging and Mechanisms of Disease
NPJ Aging and Mechanisms of Disease
Immunoglobulin G (IgG) functionality can drastically change from anti- to proinflammatory by alterations in the IgG N-glycan patterns. Our previous studies have demonstrated that IgG N-glycans associated with the risk factors of dementia, such as agi
Autor:
Xiaoyu Zhang, You Li, Pu Zhao, Man-Li Zhong, Tao Wang, Chuang Guo, Gao Huiling, Xiancheng Zhang
Publikováno v:
ACS Chemical Neuroscience. 11:4240-4253
Background: Tauopathies refer to a group of neurodegenerative disorders caused by the accumulation of insoluble hyperphosphorylated Tau protein in the brain. Previous work has shown that hexapeptide 306VQIVYK311 (PHF6) located in the repeat domain 3
Autor:
Xuyang Wen, Jiayan Fan, Renbing Jia, Huixue Wang, Shengfang Ge, Peiwei Chai, He Zhang, Xiaoyu Zhang, Xianqun Fan, Tianyi Ding
Publikováno v:
Molecular Therapy: Oncolytics, Vol 18, Iss, Pp 317-325 (2020)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Although CCCTC binding factor (CTCF) has been demonstrated to play a variety of often contradictory roles in tumorigenesis, little is known about its function in the tumorigenesis of ocular melanoma. Here, we generated two artificial CTCF peptides (D