Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Vishwanath R. Lingappa"'
Autor:
Jonathan C. Reed, Kent Matlack, Daryl J. Phuong, J. Victor Swain, Clarence R. Hurt, Beverly Freeman, Jaisri R. Lingappa, Dennis Solas, Dylan T. B. Ressler, Anatoliy Kitaygorodskyy, Vishwanath R. Lingappa
Publikováno v:
Journal of Virology
The success of antiretroviral treatment for HIV-1 is at risk of being undermined by the growing problem of drug resistance. Thus, there is a need to identify antiretrovirals that act on viral life cycle stages not targeted by drugs in use, such as th
Publikováno v:
Viruses
Viruses, Vol 13, Iss 451, p 451 (2021)
Viruses, Vol 13, Iss 451, p 451 (2021)
The concerning increase in HIV-1 resistance argues for prioritizing the development of host-targeting antiviral drugs because such drugs can offer high genetic barriers to the selection of drug-resistant viral variants. Targeting host proteins could
Autor:
Brook C. Barajas, Nick Westergreen, John V. Swain, Dylan T. B. Ressler, Jaisri R. Lingappa, Daryl J. Phuong, Vishwanath R. Lingappa, Jonathan C. Reed
During immature capsid assembly in cells, human immunodeficiency virus type 1 (HIV-1) Gag co-opts a host RNA granule, forming a pathway of intracellular assembly intermediates containing host components, including two cellular facilitators of assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b3210ab970b3cfa1346de408b28117
https://europepmc.org/articles/PMC5899207/
https://europepmc.org/articles/PMC5899207/
Autor:
Nick Westergreen, Daryl J. Phuong, Jaisri R. Lingappa, Vishwanath R. Lingappa, Jonathan C. Reed, Dylan T. B. Ressler, John V. Swain, Brook C. Barajas
During immature capsid assembly in cells, the Gag protein of HIV-1 and other primate lentiviruses co-opts a host RNA granule, forming a pathway of assembly intermediates that contains host components, including two cellular enzymes shown to facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caef7badb0d2daf50a874d6afe192964
Autor:
Mengde Lu, Robert Bowser, Vishwanath R. Lingappa, Jiyan An, Arie Gruzman, Jian Liu, Armin Akhavan
Publikováno v:
International Journal of Molecular Sciences, Vol 11, Iss 10, Pp 4051-4062 (2010)
International Journal of Molecular Sciences
Volume 11
Issue 10
Pages 4051-4062
International Journal of Molecular Sciences
Volume 11
Issue 10
Pages 4051-4062
We recently reported the presence of a novel 32 kDa protein immunoreactive to a copper, zinc superoxide dismutase (SOD1) antibody within the spinal cord of patients with amyotrophic lateral sclerosis (ALS). This unique protein species was generated b
Publikováno v:
The FASEB Journal. 22:612-621
Post-translational modifications of the extracellular matrix receptor dystroglycan (DG) determine its functional state, and defects in these modifications are linked to muscular dystrophies and cancers. A prominent feature of DG biosynthesis is a pre
Publikováno v:
Nature. 417:87-91
Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are directed to one of four submitochondrial compartments--the outer mitochondrial membrane, the inner mitochondrial membrane,
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 6, Pp 1149-1162 (1997)
Lipoprotein assembly requires a complex and regulated set of events that includes apolipoprotein B (apoB) translocation across the endoplasmic reticulum (ER) membrane, folding, and association with lipids. Unlike simple secretory proteins which are c
Autor:
Xianfu Wu, Vishwanath R. Lingappa, Christine Nichols, M. Dharma Prasad, Vinod Asundi, Andy Atuegbu, Usha F. Lingappa, Debendranath Dey, Michael Corpuz, Shao Feng Yu, Clarence R. Hurt, William Hansen, Alfredo Calayag, Charles E. Rupprecht, Emma Harrell, Hong Shi, Amanda Macieik, James A. Ellison, Jean Francis, Jaisri R. Lingappa, W. Ian Lipkin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 10
We present an unconventional approach to antiviral drug discovery, which is used to identify potent small molecules against rabies virus. First, we conceptualized viral capsid assembly as occurring via a host-catalyzed biochemical pathway, in contras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454de303dd766e81c8e537fd6712eef9
Autor:
S L Chuck, Vishwanath R. Lingappa
Publikováno v:
Journal of Biological Chemistry. 268:22794-22801
In contrast to typical secretory proteins, apolipoprotein B pauses at distinct points along the nascent chain during its translocation into the lumen of the endoplasmic reticulum. Specific pause transfer sequences mediate such discrete pauses in the