Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Thomas Tuschl"'
Autor:
Fiorella Ghisays, Claudia Canasto-Chibuque, Marcel Hohl, Thomas Tuschl, Aitor Garzia, John H.J. Petrini, Hexiao Wang, Sharon A. Savage
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Telomere repeat containing RNAs (TERRAs) are a family of long non-coding RNAs transcribed from the subtelomeric regions of eukaryotic chromosomes. TERRA transcripts can form R-loops at chromosome ends; however the importance of these structures or th
Publikováno v:
Cell reports. 36(5)
Reversible monoubiquitination of small subunit ribosomal proteins RPS2/uS5 and RPS3/uS3 has been noted to occur on ribosomes involved in ZNF598-dependent mRNA surveillance. Subsequent deubiquitination of RPS2 and RPS3 by USP10 is critical for recycli
Autor:
Stefan Weitzer, Katharina Heitmeier, Thomas Tuschl, Carla Schmidt, Samoil Sekulovski, Silvia Panizza, Pascal Devant, Frank Baas, Simon Trowitzsch, Marie Barth, Javier Martinez, Tasos Gogakos, Anda Pitiriciu, E.P. Ramsay
Introns of human transfer RNA precursors (pre-tRNAs) are excised by the tRNA splicing endonuclease TSEN in complex with the RNA kinase CLP1. Mutations in TSEN/CLP1 occur in patients with pontocerebellar hypoplasia (PCH), however, their role in the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae00805e04bdd8666fb8bbc2f817d445
https://doi.org/10.1101/2020.08.03.234229
https://doi.org/10.1101/2020.08.03.234229
Autor:
Hermann Steller, Joe Rodriguez, Cindy Meyer, Daniel Briskin, Sigi Benjamin-Hong, Stefanie Gerstberger, Thomas Tuschl, Claudia Bognanni, Kimberly Bogardus
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 758-772 (2017)
Non-coding RNA biogenesis in higher eukaryotes has not been fully characterized. Here, we studied the Drosophila melanogaster Rexo5 (CG8368) protein, a metazoan-specific member of the DEDDh 3′-5′ single-stranded RNA exonucleases, by genetic, bioc
Autor:
Anna Thrun, Annarita Patrizi, Charles S. Umbaugh, Teresa Dallinger, Sylvia Kreger, Pratik R. Patil, Claudio A. P. Joazeiro, Jia Liu, Gregory A. Cox, Yu Kigoshi-Tansho, Aitor Garzia, Thomas Tuschl
Publikováno v:
Mol Cell
Summary Incompletely synthesized nascent chains obstructing large ribosomal subunits are targeted for degradation by ribosome-associated quality control (RQC). In bacterial RQC, RqcH marks the nascent chains with C-terminal alanine (Ala) tails that a
Autor:
Henrik Molina, Cindy Meyer, Seyed Mehdi Jafarnejad, Clément Chapat, Thomas Tuschl, Nahum Sonenberg, Mehdi Amiri, Aitor Garzia, Pavel Morozov, Tasos Gogakos, Maayan Shapiro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Garzia, A, Jafarnejad, SM, Meyer, C, Chapat, C, Gogakos, T, Morozov, P, Amiri, M, Shapiro, M, Molina, H, Tuschl, T & Sonenberg, N 2017, ' The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. ', Nature Communications, vol. 8, 16056 . https://doi.org/10.1038/ncomms16056
Nature Communications
Garzia, A, Jafarnejad, SM, Meyer, C, Chapat, C, Gogakos, T, Morozov, P, Amiri, M, Shapiro, M, Molina, H, Tuschl, T & Sonenberg, N 2017, ' The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. ', Nature Communications, vol. 8, 16056 . https://doi.org/10.1038/ncomms16056
Nature Communications
Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated quality control (RQC), followed by degradation of the aberrant mRNA and polypeptide, ribosome disassembly and recycling. Although ribosomal subunit dissociation and na
Publikováno v:
Methods. :101-110
Fluorescence in situ hybridization (FISH) and immunofluorescence (IF) are sensitive techniques used for detecting nucleic acids and proteins in cultured cells. However, these techniques are rarely applied together, and standard protocols are not read
The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
Autor:
Benedetta Campana, Daniel Teupser, Muthiah Manoharan, Stefanie Gerstberger, Markus H. Heim, Mehrpouya Balaghy Mobin, Klaus Charisse, Markus Stoffel, Thomas Tuschl
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications, 7
Nature Communications
Nature Communications, 7
The liver is essential for the synthesis of plasma proteins and integration of lipid metabolism. While the role of transcriptional networks in these processes is increasingly understood, less is known about post-transcriptional control of gene expres
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Liposarcoma is the most common soft tissue sarcoma. Molecularly targeted therapeutics have had limited efficacy in liposarcomas, in part because of inadequate knowledge of the complex molecular alterations in these tumors. Our recent study revealed t
Autor:
Geoffrey G. Hesketh, Thomas Tuschl, Idit Anna Gelbart, Masahiro Morita, Sung-Hoon Kim, Anne-Claude Gingras, Nahum Sonenberg, Thomas F. Duchaine, Maayan Shapiro, Noam Stern-Ginossar, Tommy Alain, Clément Chapat, Seyed Mehdi Jafarnejad, Arkady Khoutorsky, Jan Attig, Aitor Garzia, Christos G. Gkogkas, Edna Matta-Camacho, Meztli Arguello
Publikováno v:
eLife, Vol 7 (2018)
Jafarnejad, S M, Chapat, C, Matta-Camacho, E, Gelbart, I A, Hesketh, G G, Arguello, M, Garzia, A, Kim, S-H, Attig, J, Shapiro, M, Morita, M, Khoutorsky, A, Alain, T, Christos, G G, Stern-Ginossar, N, Tuschl, T, Gingras, A-C, Duchaine, T F & Sonenberg, N 2018, ' Translational control of ERK signaling through miRNA/4EHP-directed silencing ', eLife, vol. 7, e35034 . https://doi.org/10.7554/eLife.35034
Jafarnejad, S M, Chapat, C, Matta-Camacho, E, Gelbart, I A, Hesketh, G G, Arguello, M, Garzia, A, Kim, S, Attig, J, Shapiro, M, Morita, M, Khoutorsky, A, Alain, T, Gkogkas, C, Stern-Ginossar, N, Tuschl, T, Gingras, A-C, Duchaine, T F & Sonenberg, N 2018, ' Translational control of ERK signaling through miRNA/4EHP-directed silencing ', eLIFE . https://doi.org/10.7554/eLife.35034
eLife
Jafarnejad, S M, Chapat, C, Matta-Camacho, E, Gelbart, I A, Hesketh, G G, Arguello, M, Garzia, A, Kim, S-H, Attig, J, Shapiro, M, Morita, M, Khoutorsky, A, Alain, T, Christos, G G, Stern-Ginossar, N, Tuschl, T, Gingras, A-C, Duchaine, T F & Sonenberg, N 2018, ' Translational control of ERK signaling through miRNA/4EHP-directed silencing ', eLife, vol. 7, e35034 . https://doi.org/10.7554/eLife.35034
Jafarnejad, S M, Chapat, C, Matta-Camacho, E, Gelbart, I A, Hesketh, G G, Arguello, M, Garzia, A, Kim, S, Attig, J, Shapiro, M, Morita, M, Khoutorsky, A, Alain, T, Gkogkas, C, Stern-Ginossar, N, Tuschl, T, Gingras, A-C, Duchaine, T F & Sonenberg, N 2018, ' Translational control of ERK signaling through miRNA/4EHP-directed silencing ', eLIFE . https://doi.org/10.7554/eLife.35034
eLife
MicroRNAs (miRNAs) exert a broad influence over gene expression by directing effector activities that impinge on translation and stability of mRNAs. We recently discovered that the cap-binding protein 4EHP is a key component of the mammalian miRNA-In