Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sue Chow"'
Autor:
Mark D. Minden, Sue Chow, David W. Hedley, T. Vincent Shankey, Maria Watson, Cheryl H. Arrowsmith, Dalia Barsyte
Publikováno v:
Cytometry Part A. 85:78-87
Epigenetic regulation of genes involved in cell growth, survival, or differentiation through histone modifications is an important determinant of cancer development and outcome. The basic science of epigenetics uses analytical tools that, although po
Publikováno v:
Leukemia & Lymphoma. 42:429-443
Inhibitors of Bcl-2 may be useful therapeutic agents for the treatment of a wide variety of malignancies including leukemia. A potential prototype of such a compound is the endogenous Bcl-2 and Bcl-xL binding protein BAD. Previous reports indicate th
Publikováno v:
Current Protocols in Cytometry
Signal transduction pathways link external stimuli with cellular responses, which normally regulate cell proliferation, death, and differentiation. The study of signal transduction was revolutionized through the development of phospho-specific antibo
Autor:
Suzanne Trudel, Alessandro Datti, Kyle Lee, Xiaoming Wang, David W. Hedley, Reza Beheshti Zavareh, Marcela Gronda, Jeff Wrana, Rose Hurren, Aaron D. Schimmer, Sue Chow, Yuanxiao Zhu, Xinliang Mao, Sheng Ben Liang, Nazir Jamal, Rodger E. Tiedemann, Hans A. Messner, A. Keith Stewart, G. Wei Xu, Chang Xin Shi
D-cyclins are regulators of cell division that act in a complex with cyclin-dependent kinases to commit cells to a program of DNA replication. D-cyclins are overexpressed in many tumors, including multiple myeloma and leukemia, and contribute to dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8188acb7eededcd9809d1cb6880f311e
http://hdl.handle.net/11391/123177
http://hdl.handle.net/11391/123177
Autor:
Clare Henderson, Debbie M. Gurfinkel, David W. Hedley, Christina Berube, Aaron D. Schimmer, Rose Hurren, Marcela Gronda, Sue Chow
Publikováno v:
Apoptosis : an international journal on programmed cell death. 11(9)
Triterpenoids are a novel class of compounds being investigated as potential therapeutic agents for the treatment of prostate cancer and other malignancies. Asiatic acid (AA) is a member of the ursane family of triterpenoids and has anticancer activi
Publikováno v:
Cytometry. 46(2)
Cancer cells frequently show abnormal signaling via the mitogen activated protein kinase (MAP kinase) pathway due to increased activity of surface receptors for growth factors, or as a result of ras mutations. The development of potent anti-cancer ag
Autor:
David W. Hedley, Sue Chow
Publisher Summary Glutathione (GSH) plays a key role in both carcinogenesis and resistance to cancer treatment. Drug resistance is the central problem in cancer chemotherapy. Although clearly multifactorial, the emergence of drug resistance in cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef6c0b39a39ac9a6e0d4d5a55bdc731c
https://doi.org/10.1016/s0091-679x(08)61066-3
https://doi.org/10.1016/s0091-679x(08)61066-3
Autor:
David W. Hedley, Karen Wl Yee, Vikas Gupta, Mark D. Minden, Aaron D. Schimmer, Andre C. Schuh, Joseph Brandwein, Sue Chow
Publikováno v:
Blood. 114:2073-2073
Abstract 2073 Poster Board II-50 Patients age 18-65 with acute myeloid leukemia (AML) who had persistent leukemia after 3+7 induction with cytarabine and daunorubicin, or relapsed within 24 months of achieving CR, and whose blasts were c-kit (CD117)
Autor:
David W. Hedley, Marcela Gronda, Aaron D. Schimmer, Kyle Lee, A. Keith Stewart, Xinliang Mao, Suzanne Trudel, Rose Hurren, Sue Chow, Shengben Liang
Publikováno v:
Blood. 110:1507-1507
Cyclin Ds are key regulators of the cell cycle that are frequently over-expressed in multiple myeloma and leukemia and act to promote the phosphorylation of Rb, thereby facilitating the transition from G1 to S phase. Over-expression of cyclin Ds incr