Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sine Reker Hadrup"'
Autor:
Sine Reker Hadrup, Amalie Kai Bentzen
Publikováno v:
Immuno-Oncology Technology
Bentzen, A K & Hadrup, S R 2019, ' T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation ', Immuno-Oncology Technology, vol. 2, pp. 1-10 . https://doi.org/10.1016/j.iotech.2019.06.003
Immuno-Oncology and Technology, Vol 2, Iss, Pp 1-10 (2019)
Immunooncol Technol
Bentzen, A K & Hadrup, S R 2019, ' T-cell-receptor cross-recognition and strategies to select safe T-cell receptors for clinical translation ', Immuno-Oncology Technology, vol. 2, pp. 1-10 . https://doi.org/10.1016/j.iotech.2019.06.003
Immuno-Oncology and Technology, Vol 2, Iss, Pp 1-10 (2019)
Immunooncol Technol
Adoptive transfer of T-cell-receptor (TCR)-transduced T cells has shown promising results for cancer treatment, but has also produced severe immunotoxicities caused by on-target as well as off-target TCR recognition. Off-target toxicities are related
Autor:
Morten Nielsen, Susana Patricia Amaya Hernandez, Anne Ortved Gang, Helle Rus Povlsen, Ditte Stampe Hersby, Tripti Tamhane, Sunil Kumar Saini, Sine Reker Hadrup
Publikováno v:
Saini, S K, Hersby, D S, Tamhane, T, Povlsen, H R, Amaya Hernandez, S P, Nielsen, M, Gang, A O & Hadrup, S R 2021, ' SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients ', Science immunology, vol. 6, no. 58, eabf7550, pp. 1-16 . https://doi.org/10.1126/sciimmunol.abf7550
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Saini, S K, Hersby, D S, Tamhane, T, Povlsen, H R, Amaya Hernandez, S P, Nielsen, M, Gang, A O & Hadrup, S R 2021, ' SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients ', Science immunology, vol. 6, no. 58, eabf7550 . https://doi.org/10.1126/sciimmunol.abf7550
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Saini, S K, Hersby, D S, Tamhane, T, Povlsen, H R, Amaya Hernandez, S P, Nielsen, M, Gang, A O & Hadrup, S R 2021, ' SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patients ', Science immunology, vol. 6, no. 58, eabf7550 . https://doi.org/10.1126/sciimmunol.abf7550
T cells are important for effective viral clearance, elimination of virus-infected cells and long-term disease protection. To examine the full-spectrum of CD8+ T cell immunity in COVID-19, we experimentally evaluated 3141 major histocompatibility (MH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103014ddd0f84dc3bd5cbe8fef4a3434
https://curis.ku.dk/portal/da/publications/sarscov2-genomewide-t-cell-epitope-mapping-reveals-immunodominance-and-substantial-cd8-t-cell-activation-in-covid19-patients(ed878466-1db0-4ceb-bbee-d2134bc6cf8a).html
https://curis.ku.dk/portal/da/publications/sarscov2-genomewide-t-cell-epitope-mapping-reveals-immunodominance-and-substantial-cd8-t-cell-activation-in-covid19-patients(ed878466-1db0-4ceb-bbee-d2134bc6cf8a).html
Autor:
John E. Pimanda, Anne-Mette Bjerregaard, Andrea Marion Marquard, Kirsten Grønbæk, Aron Charles Eklund, Sine Reker Hadrup, Kathrine Valentini Jensen, Staffan Holmberg-Thydén, Anne Ortved Gang, Inge Høgh Dufva, Zoltan Szallasi, Ashwin Unnikrishnan, Amalie Kai Bentzen, Nicola Ternette, Tripti Tamhane, Annie Borch, Andreas Due Ørskov, Govardhan Anande, Marianne Bach Treppendahl, Sunil Kumar Saini, Anders Gorm Pedersen
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Saini, S K, Ørskov, A D, Bjerregaard, A M, Unnikrishnan, A, Holmberg-Thydén, S, Borch, A, Jensen, K V, Anande, G, Bentzen, A K, Marquard, A M, Tamhane, T, Treppendahl, M B, Gang, A O, Dufva, I H, Szallasi, Z, Ternette, N, Pedersen, A G, Eklund, A C, Pimanda, J, Grønbæk, K & Hadrup, S R 2020, ' Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers ', Nature Communications, vol. 11, no. 1, 5660 . https://doi.org/10.1038/s41467-020-19464-8
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Saini, S K, Ørskov, A D, Bjerregaard, A M, Unnikrishnan, A, Holmberg-Thydén, S, Borch, A, Jensen, K V, Anande, G, Bentzen, A K, Marquard, A M, Tamhane, T, Treppendahl, M B, Gang, A O, Dufva, I H, Szallasi, Z, Ternette, N, Pedersen, A G, Eklund, A C, Pimanda, J, Grønbæk, K & Hadrup, S R 2020, ' Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers ', Nature Communications, vol. 11, no. 1, 5660 . https://doi.org/10.1038/s41467-020-19464-8
Human endogenous retroviruses (HERV) form a substantial part of the human genome, but mostly remain transcriptionally silent under strict epigenetic regulation, yet can potentially be reactivated by malignant transformation or epigenetic therapies. H
Autor:
Karoline Laske, Marij J. P. Welters, Cécile Gouttefangeas, Natasja Wulff Pedersen, Steffen Walter, Dominik Maurer, Sine Reker Hadrup
Publikováno v:
Pedersen, N W, Laske, K, Maurer, D, Welters, M, Walter, S, Gouttefangeas, C & Hadrup, S R 2020, ' Optimization in Detection of Antigen-Specific T Cells Through Differentially Labeled MHC Multimers ', Cytometry. Part A, vol. 97, no. 9, pp. 955-964 . https://doi.org/10.1002/cyto.a.23942
Cytometry
Cytometry Part A
Cytometry
Cytometry Part A
A large variety of fluorescent molecules are used on a regular basis to tag major histocompatibility complex (MHC) multimers for detection of antigen‐specific T cells. We have evaluated the way in which the choice of fluorescent label can impact th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae2b9c64bd8e059b6da3d420c9668dd
https://hdl.handle.net/1887/121318
https://hdl.handle.net/1887/121318
Autor:
Theo Sturm, Inge Marie Svane, Amalie Kai Bentzen, Sofie Ramskov, Tim Fugmann, Sine Reker Hadrup, Per thor Straten, Rikke Andersen, Nadia Viborg, Özcan Met, Vibeke Mindahl Rafa
Publikováno v:
Viborg, N, Ramskov, S, Andersen, R S, Sturm, T, Fugmann, T, Bentzen, A K, Rafa, V M, Straten, P T, Svane, I M, Met, Ö & Hadrup, S R 2019, ' T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients ', OncoImmunology, vol. 8, no. 12, e1663107 . https://doi.org/10.1080/2162402x.2019.1663107
Viborg, N, Ramskov, S, Andersen, R S, Sturm, T, Fugmann, T, Bentzen, A K, Rafa, V M, Straten, P T, Svane, I M, Met, Ö & Hadrup, S R 2019, ' T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients ', OncoImmunology, vol. 8, no. 12, 1663107 . https://doi.org/10.1080/2162402X.2019.1663107
OncoImmunology, Vol 8, Iss 12 (2019)
Oncoimmunology
Viborg, N, Ramskov, S, Andersen, R S, Sturm, T, Fugmann, T, Bentzen, A K, Rafa, V M, Straten, P T, Svane, I M, Met, Ö & Hadrup, S R 2019, ' T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients ', OncoImmunology, vol. 8, no. 12, 1663107 . https://doi.org/10.1080/2162402X.2019.1663107
OncoImmunology, Vol 8, Iss 12 (2019)
Oncoimmunology
Advances within cancer immunotherapy have fueled a paradigm shift in cancer treatment, resulting in increasing numbers of cancer types benefitting from novel treatment options. Despite originally being considered an immunologically silent malignancy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06470d1f3c700e1a86bdf6c968a6b79c
https://orbit.dtu.dk/en/publications/66ae6ee0-7fab-46bd-8463-2f2f23a3bf06
https://orbit.dtu.dk/en/publications/66ae6ee0-7fab-46bd-8463-2f2f23a3bf06
Autor:
Ashley Marie Regazzi, Taha Merghoub, Tripti Tamhane, Colleen Anne Maher, Samuel Funt, Anne-Mette Bjerregaard, Hikmat Al-Ahmadie, Nana Haahr Overgaard, Jedd D. Wolchok, Amalie Kai Bentzen, Sine Reker Hadrup, Jeppe Sejerø Holm, Dean F. Bajorin, Jonathan E. Rosenberg, Morten Nielsen, Alexandra Snyder, James L. Reading, Phillip Wong
Publikováno v:
Journal of Clinical Oncology. 38:3075-3075
3075 Background: Proliferation of CD8 T cells can be detected in the blood of cancer patients (pts) following a single dose of immune checkpoint blockade (ICB) and tends to be more robust in responding pts. Furthermore, tumor mutational burden (TMB)
Autor:
Per thor Straten, Mirjam H.M. Heemskerk, Tina Seremet, Thomas Mørch Frøsig, Rikke Birgitte Lyngaa, Jiawei Yap, Gijsbert M. Grotenbreg, Inge Marie Svane, Sine Reker Hadrup
Publikováno v:
Cytometry Part A. 87:967-975
We designed conditional ligands restricted to HLA-B*08:01, -B*35:01, and -B*44:05 and proved the use of a conditional ligand previously designed for HLA-B*15:02 together with HLA-B*15:01. Furthermore, we compared the detection capabilities of specifi
Autor:
Thomas Mørch Frøsig, Per thor Straten, Stine Kiaer Larsen, Özcan Met, Sine Reker Hadrup, Marco Donia, Rikke Birgitte Lyngaa, Inge Marie Svane
Publikováno v:
Frøsig, T M, Lyngaa, R B, Met, Ö, Larsen, S K, Donia, M, Svane, I M, Straten, P T & Hadrup, S R 2015, ' Broadening the repertoire of melanoma-associated T-cell epitopes ', Cancer Immunology, Immunotherapy, vol. 64, no. 5, pp. 609-620 . https://doi.org/10.1007/s00262-015-1664-x
Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy
Immune therapy has provided a significant breakthrough in the treatment of metastatic melanoma. Despite the remarkable clinical efficacy and established involvement of effector CD8 T cells, the knowledge of the exact peptide-MHC complexes recognized
Autor:
Cliburn Chan, Kivin Jakobsen, Charlotte Halgreen, Rick Stanton, Natasja Wulff Pedersen, Sine Reker Hadrup, Cécile Gouttefangeas, P. Anoop Chandran, Jonathan Rebhahn, Scott R. White, Richard H. Scheuermann, Mathilde Dalsgaard Hoff, Tim R. Mosmann, Alexandra J. Lee, Yu Qian, Nadia Viborg Petersen
Publikováno v:
Frontiers in Immunology
Pedersen, N W, Chandran, P A, Qian, Y, Rebhahn, J, Petersen, N V, Hoff, M D, White, S, Lee, A J, Stanton, R, Halgreen, C, Jakobsen, K, Mosmann, T, Gouttefangeas, C, Chan, C, Scheuermann, R H & Hadrup, S R 2017, ' Automated Analysis of Flow Cytometry Data to Reduce Inter-Lab Variation in the Detection of Major Histocompatibility Complex Multimer-Binding T Cells ', Frontiers in Immunology, vol. 8, 858 . https://doi.org/10.3389/fimmu.2017.00858
Frontiers in Immunology, Vol 8 (2017)
Pedersen, N W, Chandran, P A, Qian, Y, Rebhahn, J, Petersen, N V, Hoff, M D, White, S, Lee, A J, Stanton, R, Halgreen, C, Jakobsen, K, Mosmann, T, Gouttefangeas, C, Chan, C, Scheuermann, R H & Hadrup, S R 2017, ' Automated Analysis of Flow Cytometry Data to Reduce Inter-Lab Variation in the Detection of Major Histocompatibility Complex Multimer-Binding T Cells ', Frontiers in Immunology, vol. 8, 858 . https://doi.org/10.3389/fimmu.2017.00858
Frontiers in Immunology, Vol 8 (2017)
Manual analysis of flow cytometry data and subjective gate-border decisions taken by individuals continue to be a source of variation in the assessment of antigen-specific T cells when comparing data across laboratories, and also over time in individ
Autor:
Amalie Kai Bentzen, Sine Reker Hadrup
Publikováno v:
Bentzen, A K & Hadrup, S R 2017, ' Evolution of MHC-based technologies used for detection of antigen-responsive T cells ', Cancer Immunology, Immunotherapy, vol. 66, no. 5, pp. 657-666 . https://doi.org/10.1007/s00262-017-1971-5
Cancer Immunology, Immunotherapy
Cancer Immunology, Immunotherapy
T cell-mediated recognition of peptide-major histocompatibility complex (pMHC) class I and II molecules is crucial for the control of intracellular pathogens and cancer, as well as for stimulation and maintenance of efficient cytotoxic responses. Suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cde851bb6a39e76605d50da9ac8d7a
https://orbit.dtu.dk/en/publications/767755c5-3440-48cc-af14-82eec8c28156
https://orbit.dtu.dk/en/publications/767755c5-3440-48cc-af14-82eec8c28156