Zobrazeno 21 - 30
of 53
pro vyhledávání: '"Sergio Valente"'
Autor:
Francesco Spallotta, Carlo Gaetano, Antonello Mai, Andreas M. Zeiher, Fabio Martelli, Sergio Valente, Chiara Cencioni
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 17643-17663 (2013)
International Journal of Molecular Sciences; Vol 14
International Journal of Molecular Sciences, Vol 14, Iss 9, Pp 17643-17663 (2013)
International Journal of Molecular Sciences; Vol 14
Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are availab
Autor:
Irene Bozzoni, Stefania Straino, Claudia Colussi, Antonella Farsetti, Matteo Vecellio, Francesco Spallotta, Jessica Rosati, Sergio Valente, Maurizio C. Capogrossi, Alfredo Pontecorvi, Antonello Mai, Silvia Tardivo, Julie Martone, Carlo Gaetano, Simona Nanni
Publikováno v:
The Journal of biological chemistry
288 (2013): 22915–22929. doi:10.1074/jbc.M113.484337
info:cnr-pdr/source/autori:Francesco Spallotta 1; Silvia Tardivo 2; Simona Nanni 3,7; Jessica D. Rosati 1; Stefania Straino 2,4 ; Antonello Mai 5; Matteo Vecellio1; Sergio Valente 5; Maurizio C. Capogrossi 3; Antonella Farsetti 7,6; Julie Martone 8; Irene Bozzoni 8; Alfredo Pontecorvi 3; Carlo Gaetano 9; Claudia Colussi 3,7/titolo:Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia/doi:10.1074%2Fjbc.M113.484337/rivista:The Journal of biological chemistry (Print)/anno:2013/pagina_da:22915/pagina_a:22929/intervallo_pagine:22915–22929/volume:288
288 (2013): 22915–22929. doi:10.1074/jbc.M113.484337
info:cnr-pdr/source/autori:Francesco Spallotta 1; Silvia Tardivo 2; Simona Nanni 3,7; Jessica D. Rosati 1; Stefania Straino 2,4 ; Antonello Mai 5; Matteo Vecellio1; Sergio Valente 5; Maurizio C. Capogrossi 3; Antonella Farsetti 7,6; Julie Martone 8; Irene Bozzoni 8; Alfredo Pontecorvi 3; Carlo Gaetano 9; Claudia Colussi 3,7/titolo:Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia/doi:10.1074%2Fjbc.M113.484337/rivista:The Journal of biological chemistry (Print)/anno:2013/pagina_da:22915/pagina_a:22929/intervallo_pagine:22915–22929/volume:288
Histone deacetylase inhibitors (DIs) are promising drugs for the treatment of several pathologies including ischemic and failing heart where they demonstrated efficacy. However, adverse side effects and cardiotoxicity have also been reported. Remarka
Autor:
Claus Jacob, Sergio Valente, Denyse Bagrel, Zhanjie Xu, Peter Meiser, Emilie Bana, Antonello Mai, Gilbert Kirsch, Clemens Zwergel, Artur M. S. Silva
Publikováno v:
European Journal of Organic Chemistry. 2013:2869-2877
The reactivity of 4-(1-butoxyvinyl)-2H-chromen-2-one (1) and (E)-4-(2-butoxyvinyl)-2H-chromen-2-one (2) as diene in thermal Diels–Alder cycloaddition reactions with several electron-poor dienophiles is reported. Among several dienophiles used in th
Autor:
Paolo Mellini, Donatella Del Bufalo, Sébastien Moniot, Lucia Polletta, Clemens Steegborn, Marco Tafani, Ilaria Carnevale, Roberta Budriesi, Maria Tardugno, Lucia Altucci, Chiara Gabellini, Sandra Atlante, Daniela Trisciuoglio, Antonello Mai, Vincenzo Carafa, Angela Nebbioso, Serena Saladini, Sergio Valente, Francesco Spallotta, Clemens Zwergel, Chiara Cencioni, Carlo Gaetano
Publikováno v:
Journal of medicinal chemistry (2016).
info:cnr-pdr/source/autori:Valente S, Mellini P, Spallotta F, Carafa V, Nebbioso A, Polletta L, Carnevale I, Saladini S, Trisciuoglio D, Gabellini C, Tardugno M, Zwergel C, Cencioni C, Atlante S, Moniot S, Steegborn C, Budriesi R, Tafani M, Del Bufalo D, Altucci L, Gaetano C, Mai A./titolo:1,4-Dihydropyridines Active on the SIRT1%2FAMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells./doi:/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume
info:cnr-pdr/source/autori:Valente S, Mellini P, Spallotta F, Carafa V, Nebbioso A, Polletta L, Carnevale I, Saladini S, Trisciuoglio D, Gabellini C, Tardugno M, Zwergel C, Cencioni C, Atlante S, Moniot S, Steegborn C, Budriesi R, Tafani M, Del Bufalo D, Altucci L, Gaetano C, Mai A./titolo:1,4-Dihydropyridines Active on the SIRT1%2FAMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells./doi:/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume
Modulators of sirtuins are considered promising therapeutic targets for the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases. Here we prepared new 1,4-dihydropyridines (DHPs) bearing changes at the C2/C6, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4bbdf098839e19177d1bd2f68f8889
http://hdl.handle.net/11573/870523
http://hdl.handle.net/11573/870523
Lysine demethylase 1 (LSD1) plays an important role in mediating the expression of genes involved in cancer and non-cancer diseases such as viral infections, cardiovascular and neurodegenerative disorders. It is involved in a number of processes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b34fa3d359d482f0990303e31d1946
http://hdl.handle.net/11573/870518
http://hdl.handle.net/11573/870518
Autor:
Ignacio Celestino, Maria Elena Marcocci, Anna Teresa Palamara, Domenica Donatella Li Puma, Sergio Valente, Giovanna Simonetti, Simona Panella, Antonello Mai, Clemens Zwergel, Lucia Nencioni
Publikováno v:
Europe PubMed Central
Aim: Histone deacetylases (HDACs) regulate the life cycle of several viruses. We investigated the ability of different HDAC inhibitors, to interfere with influenza virus A/Puerto Rico/8/34/H1N1 (PR8 virus) replication in Madin-Darby canine kidney and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6ee2062e9cf371008cec81a6f1836f
http://hdl.handle.net/10807/171421
http://hdl.handle.net/10807/171421
Autor:
Nathaniel Edward Bennett Saidu, Denyse Bagrel, Gilbert Kirsch, Sergio Valente, Mathias Montenarh, Emilie Bana
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:1584-1593
Coumarins and coumarin derivatives as well as diallyl polysulfides are well known as anticancer drugs. In order to find new drugs with anticancer activities, we combined coumarins with polysulfides in the form of di-coumarin polysulfides. These novel
Autor:
Roberto Cirilli, Maria Tardugno, Aristotele Karytinos, Saverio Minucci, Antonello Mai, Sergio Valente, Simona Pilotto, Claudia Binda, Mauro Romanenghi, Federico Forneris, Dale E. Edmondson, Andrea Mattevi, Giuseppe Ciossani, Oronza A. Botrugno
Publikováno v:
Journal of the American Chemical Society. 132:6827-6833
LSD1 and LSD2 histone demethylases are implicated in a number of physiological and pathological processes, ranging from tumorigenesis to herpes virus infection. A comprehensive structural, biochemical, and cellular study is presented here to probe th
Autor:
Fabio Manzo, Sergio Valente, Angela Nebbioso, Antonello Mai, Lucia Altucci, Annamaria Scognamiglio
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2008, 1783 (10), pp.2030-8. ⟨10.1016/j.bbamcr.2008.07.007⟩
International audience; Discovered for their ability to deacetylate histones and repress transcription, HDACs are a promising target for therapy of human diseases. The class II HDACs are mainly involved in developmental and differentiation processes,
Autor:
Antonello Mai, Jorge Domínguez-Andrés, Elena Puerta, M.M. Erburu, Sergio Valente, Rosa M. Tordera, Takayoshi Suzuki, Elena Beltran, I. Muñoz-Cobo
Changes in histone acetylation could contribute to the pathogenesis of depression and antidepressant therapy. Using the chronic social defeat stress (CSDS) model of depression and different antidepressant treatments we studied the regulation of histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cadd1d6ed1bce716c27a14ea96385a
http://hdl.handle.net/11573/884185
http://hdl.handle.net/11573/884185