Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pei, W."'
Autor:
Dali Liu, Walter Fast, Pei W. Thomas, Thahani S. Habeeb Mohammad, Daniel P. Becker, Cory T. Reidl, Romila Mascarenhas, Marlon R. Lutz
Publikováno v:
ACS Omega, Vol 6, Iss 21, Pp 13567-13578 (2021)
ACS Omega
ACS Omega
An α-amido cyclobutanone possessing a C10 hydrocarbon tail was designed as a potential transition-state mimetic for the quorum-quenching metallo-γ-lactonase autoinducer inactivator A (AiiA) with the support of in-house modeling techniques and found
Autor:
Jennifer S. Brodbelt, Dann D Rivera, R. F. Pratt, Pei W. Thomas, Michael W. Crowder, Zishuo Cheng, M. Rachel Mehaffey, Yeong-Chan Ahn, Walter Fast
Publikováno v:
Chemical Science
We use mass spectrometry (MS), under denaturing and non-denaturing solution conditions, along with ultraviolet photodissociation (UVPD) to characterize structural variations in New Delhi metallo-β-lactamase (NDM) upon perturbation by ligands or muta
Autor:
Zishuo Cheng, Walter Fast, Allie Y. Chen, Michael W. Crowder, Seth M. Cohen, David L. Tierney, Pei W. Thomas, Nasa Y. Xu
Publikováno v:
ChemMedChem
New Delhi Metallo-β-lactamase-1 (NDM-1) poses an immediate threat to our most effective and widely prescribed drugs, the β-lactam containing class of antibiotics. There are no clinically relevant inhibitors to combat NDM-1, despite significant effo
Autor:
Walter Fast, Michael B. Cammarata, Pei W. Thomas, Jennifer S. Brodbelt, R. F. Pratt, Arthur F. Monzingo
Publikováno v:
Biochemistry
The divergent sequences, protein structures, and catalytic mechanisms of serine- and metallo-β- lactamases hamper the development of wide-spectrum β-lactamase inhibitors that can block both types of enzymes. The O-aryloxycarbonyl hydroxamate inacti
Autor:
Dali Liu, Pei W. Thomas, Walter Fast, Quyen Q. Hoang, Chun Xiang Wu, Boguslaw Nocek, Romila Mascarenhas
Publikováno v:
Biochemistry. 54:4342-4353
Quorum-quenching catalysts are of interest for potential application as biochemical tools for interrogating interbacterial communication pathways, as antibiofouling agents, and as anti-infective agents in plants and animals. Herein, the structure and
Autor:
Timothy P. Spicer, Jennifer S. Brodbelt, Peter Hodder, Michael B. Cammarata, Walter Fast, Pei W. Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:3138-3146
Due to the global threat of antibiotic resistance mediated by New Delhi metallo-beta-lactamase-1 (NDM-1) and the lack of structurally diverse inhibitors reported for this enzyme, we developed screening and counter-screening assays for manual and auto
Autor:
Mireya Rodriguez, Pei W. Thomas, Bodin Tuesuwan, Jing Li, Jonathan T. Kern, Wendi M. David, Sean M. Kerwin
On the basis of growing evidence for G-quadruplex DNA structures in genomic DNA and the presumed need to resolve these structures for DNA replication, the G-quadruplex DNA unwinding ability of a prototypical replicative helicase, SV40 large T-antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2316058063f5f237f79431c8137022fc
https://doi.org/10.1021/bi701747d
https://doi.org/10.1021/bi701747d
Autor:
Gregory A. Petsko, Canhui Wang, Jessica Momb, Pei W. Thomas, Dali Liu, Hua Guo, Walter Fast, Dagmar Ringe
Publikováno v:
Biochemistry
The N-acyl- l-homoserine lactone hydrolases (AHL lactonases) have attracted considerable attention because of their ability to quench AHL-mediated quorum-sensing pathways in Gram-negative bacteria and because of their relation to other enzymes in the
Autor:
Jessica Momb, Dagmar Ringe, Pei W. Thomas, Dali Liu, Quyen Q. Hoang, Walter Fast, Gregory A. Petsko
Publikováno v:
Biochemistry. 46:11789-11799
N-Acyl-l-homoserine lactone (AHL) mediated quorum-sensing regulates virulence factor production in a variety of Gram-negative bacteria. Proteins capable of degrading these autoinducers have been called "quorum-quenching" enzymes, can block many quoru
Publikováno v:
Biochemistry. 45:13385-13393
Lactone-hydrolyzing enzymes derived from some Bacillus species are capable of disrupting quorum sensing in bacteria that use N-acyl-l-homoserine lactones (AHLs) as intercellular signaling molecules. Despite the promise of these quorum-quenching enzym