Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Pablo Helguera"'
Autor:
Pinar Coskun, Sergio A. Cannas, Emiliano Zamponi, Nahuel Zamponi, Pablo Helguera, Alfredo Lorenzo, Jorge Busciglio, Gonzalo Quassollo, Katheleen Gardiner, Gustavo Pigino, Dante R. Chialvo
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Zamponi, Emiliano; Zamponi, Nahuel; Coskun, Pinar; Quassollo, Gonzalo; Lorenzo, Alfredo; Cannas, Sergio A; et al.(2018). Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells.. Aging Cell, 17(5), e12812. doi: 10.1111/acel.12812. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8m88h0wf
Aging Cell
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Zamponi, Emiliano; Zamponi, Nahuel; Coskun, Pinar; Quassollo, Gonzalo; Lorenzo, Alfredo; Cannas, Sergio A; et al.(2018). Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells.. Aging Cell, 17(5), e12812. doi: 10.1111/acel.12812. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8m88h0wf
Aging Cell
Mounting evidence implicates chronic oxidative stress as a critical driver of the aging process. Down syndrome (DS) is characterized by a complex phenotype, including early senescence. DS cells display increased levels of reactive oxygen species (ROS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b894ecceb0cb89ba5e91dc15fc467058
Wiley Online Library
Wiley Online Library
Autor:
José de Olmos, Frank M. LaFerla, Soledad de Olmos, Francisco Solá Vigo, Gabriela Kedikian, Alfredo Cáceres, Matthias Staufenbiel, Alfredo Lorenzo, Pablo Helguera, Lorena Heredia, Jorge Busciglio
Publikováno v:
Journal of Neuroscience. 26:6533-6542
Deposition of fibrillar amyloid beta (fAbeta) plays a critical role in Alzheimer's disease (AD). We have shown recently that fAbeta-induced dystrophy requires the activation of focal adhesion proteins and the formation of aberrant focal adhesion stru
Autor:
Jorge Busciglio, Pablo Helguera, Elizabeth Head, Alejandra Pelsman, Ernst J. Wolvetang, Gustavo Pigino
Publikováno v:
The Journal of Neuroscience. 25:2295-2303
Down's syndrome (DS) is characterized by mental retardation and development of Alzheimer's disease (AD). Oxidative stress and mitochondrial dysfunction are both related to neurodegeneration in DS. Several genes in chromosome 21 have been linked to ne
Publikováno v:
Journal of Visualized Experiments : JoVE
In this study, we outline a standardized protocol for the successful cryopreservation and thawing of cortical brain tissue blocks to generate highly enriched neuronal cultures. For this protocol the freezing medium used is 10% dimethyl sulfoxide (DMS
Autor:
Pablo Helguera, Jorge Busciglio, Illana Gozes, Albert Pinhasov, Douglas E. Brenneman, Osnat Ashur-Fabian, Alejandra Pelsman
Publikováno v:
Current pharmaceutical design. 13(11)
NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln, single letter code: NAPVSIPQ) and ADNF-9 (activity-dependent neurotrophic factor-9; Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala; single letter code: SALLRSIPA) are peptides derived from naturally occurring glial proteins