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pro vyhledávání: '"Neil K. Gibbs"'
Autor:
Neil K. Gibbs, Rachel E.B. Watson, Christopher E.M. Griffiths, Sarah A. Hibbert, Michael J. Sherratt
Publikováno v:
Hibbert, S, Watson, R, Griffiths, C, Gibbs, N & Sherratt, M 2019, ' Selective proteolysis by matrix metalloproteinases of photo-oxidised dermal extracellular matrix proteins ', Cell Signal, vol. 54, pp. 191-199 . https://doi.org/10.1016/j.cellsig.2018.11.024
Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f34e84c80fdbdb67169eb6e318d0dc
https://linkinghub.elsevier.com/retrieve/pii/S0898656818303024
https://linkinghub.elsevier.com/retrieve/pii/S0898656818303024
A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues
Autor:
Rachel E.B. Watson, Sarah A. Hibbert, Christopher E.M. Griffiths, Neil K. Gibbs, Anthony S. Weiss, Patrick Costello, Clair Baldock, Michael J. Sherratt
Publikováno v:
Redox Biology, Vol 5, Iss, Pp 101-113 (2015)
Redox Biology
Redox Biology
Excessive ultraviolet radiation (UVR) exposure of the skin is associated with adverse clinical outcomes. Although both exogenous sunscreens and endogenous tissue components (including melanins and tryptophan-derived compounds) reduce UVR penetration,
Low-dose ultraviolet radiation selectively degrades chromophore-rich extracellular matrix components
Autor:
Siobhan M Reilly, Michael J. Sherratt, Rachel E.B. Watson, Neil K. Gibbs, Christopher P Bayley, Christopher E.M. Griffiths
Publikováno v:
The Journal of Pathology. 222:32-40
Photoageing of human skin due to chronic exposure to ultraviolet radiation (UVR) is characterized histologically by extensive remodelling of the dermal elastic fibre system. Whilst enzymatic pathways are thought to play a major role in mediating extr
Autor:
Neil K. Gibbs, Samantha Kidd, Nicola J. Traynor, Laurent Marrot, Jean Roch Meunier, Catherine Agapakis-Causse
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 58:26-31
The fluoroquinolone antibiotic, lomefloxacin, is phototoxic in human skin exposed to UVA radiation, photosensitises DNA strand breaks and pyrimidine dimers in human keratinocytes in vitro, and is phototumorigenic in mouse skin. The p53 tumour suppres
Autor:
Wim G. Goettsch, H. van Loveren, Mary Norval, P.M. Dortant, A.P.J. Verlaan, Y. Sontag, H. van de Vliet, P. A. Steerenberg, Neil K. Gibbs, H.B. Bueno-de-Mesquita, J. Garssen, L. Geerse
Publikováno v:
Photochemistry and photobiology. 65(4)
— Ultraviolet is thought to induce skin tumors by its dual activity as a mutagenic agent and a suppressor of cell-mediated immunity. In the present study the effects of quercetin, a flavonoid-containing compound, on carcinogenesis and immunosuppres
Publikováno v:
Photodermatology, photoimmunologyphotomedicine. 12(5)
Exposure to ultraviolet B (UVB) radiation results in the suppression of many cell-mediated immune responses, and recent studies mice and murine cells in vitro suggest a shift from a T-helper 1 (Th1) to a Th2 type of response on irradiation. Active ps