Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mitschler A"'
Autor:
Conrady, M. (Marcel Chris), Suarez, I. (Irina), Gogl, G. (Gergo), Frecot, D. (Desiree Isabella), Bonhoure, A. (Anna), Kostmann, C. (Camille), Cousido-Siah, A. (Alexandra), Mitschler, A. (André), Lim, J. (JiaWen), Masson, M. (Murielle), Iftner, T. (Thomas), Stubenrauch, F. (Frank), Travé, G. (Gilles), Simon, C. (Claudia), Banks, L. (Lawrence) (editor)
Publikováno v:
Journal of Virology
Journal of Virology, American Society for Microbiology, 2020, ⟨10.1128/jvi.00730-20⟩
J Virol
Journal of Virology, American Society for Microbiology, 2020, 95 (2), ⟨10.1128/JVI.00730-20⟩
Journal of Virology, American Society for Microbiology, 2020, ⟨10.1128/jvi.00730-20⟩
J Virol
Journal of Virology, American Society for Microbiology, 2020, 95 (2), ⟨10.1128/JVI.00730-20⟩
The degradation of p53 is a hallmark of high-risk human papillomaviruses (HPVs) of the alpha genus and HPV-related carcinogenicity. The oncoprotein E6 forms a ternary complex with the E3 ubiquitin ligase E6-associated protein (E6AP) and tumor suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1211b111459ab15dd950646a100748
https://hal.archives-ouvertes.fr/hal-03058435
https://hal.archives-ouvertes.fr/hal-03058435
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:129-142
A unique zinc domain found in all of the identified members of the lipase family I.5 is surrounded by two conserved tryptophans (W61 and W212). In this study, we investigated the role of these hydrophobic residues in thermostability and thermoactivit
Autor:
Alberto Podjarny, Martín Ezequiel Noguera, Andre Mitschler, Alexandra Cousido-Siah, Juan B. Rigal, Javier Santos, Ernesto A. Roman
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 20:653-664
Frataxin is an evolutionary conserved protein that participates in iron metabolism. Deficiency of this small protein in humans causes a severe neurodegenerative disease known as Friedreich's ataxia. A number of studies indicate that frataxin binds ir
Autor:
F.X. Ruiz, Isidro Crespo, Angel R. de Lera, Alexandra Cousido-Siah, Susana Alvarez, Jaume Farrés, Andre Mitschler, Joan Gimenez-Dejoz, Alberto Podjarny, Sergio Porté, Xavier Parés
Publikováno v:
Chemico-biological interactions. 276
UVI2008, a retinoic acid receptor (RAR) β/γ agonist originated from C3 bromine addition to the parent RAR pan-agonist 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid (TTNPB), is also a selective inhibitor of
Autor:
F.X. Ruiz, Alexandra Cousido-Siah, Alberto Podjarny, Todd Robert Ryder, Erik Jagdmann, Adam Golebiowski, M. Andreoli, Michael C. Van Zandt, Darren Whitehouse, Hagen Schroeter, Paul Beckett, Adam W. Mazur, Manyian Padmanilayam, Minkoo Ji, Andre Mitschler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2027-2030
Substitution at the alpha center of the known human arginase inhibitor 2-amino-6-boronohexanoic acid (ABH) is acceptable in the active site pockets of both human arginase I and arginase II. In particular, substituents with a tertiary amine linked via
Autor:
Xavier Parés, F.X. Ruiz, Andre Mitschler, Alberto Podjarny, Jaume Farrés, Alexandra Cousido-Siah
Publikováno v:
Chemico-Biological Interactions. 202:178-185
Only one crystal structure is currently available for tumor marker AKR1B10, complexed with NADP(+) and tolrestat, which is an aldose reductase inhibitor (ARI) of the carboxylic acid type. Here, the X-ray structure of the complex of the V301L substitu
Autor:
Raul E Cachau, Karl Harlos, Yuguang Zhao, Andre Mitschler, F.X. Ruiz, Alberto Podjarny, Alexandra Cousido-Siah, Firas Fadel, Eduardo Howard
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Chitotriosidase (CHIT1) is a human chitinase belonging to the highly conserved glycosyl hydrolase family 18 (GH18). GH18 enzymes hydrolyze chitin, an N-acetylglucosamine polymer synthesized by lower organisms for structural purposes. Recently, CHIT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc2bdc73913b18ed383d09b86096ce0
http://scripts.iucr.org/cgi-bin/paper?S139900471500783X
http://scripts.iucr.org/cgi-bin/paper?S139900471500783X
Autor:
Alberto Podjarny, Andre Mitschler, Kerry Combs, Evelyn O. Sibley, Al Sabetta, Erin E. McCann, Anne L. Carrington, Eduardo Howard, Diane R. Sawicki, Janet Sredy, Brenda R. Flam, Michael C. Van Zandt
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5661-5675
Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid aldose reductase inhibitors. The compound class features a
Autor:
Alberto Podjarny, Takashi Tomizaki, Clemens Schulze-Briese, Isabelle Hazemann, Connie Darmanin, Mitsuru Oka, Ossama El-Kabbani, and Andre Mitschler
Publikováno v:
Journal of Medicinal Chemistry. 47:4530-4537
Structure determinations of human aldose reductase holoenzyme in complex with the 2S4R-,2R4S- and 2R4R-isomers of the potent inhibitor Fidarestat ((2S,4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazoline]-2-carboxamide) were carried out in order to
Autor:
Isabelle Hazemann, Alberto Podjarny, Federico M. Ruiz, Martin Karplus, Thomas D. Schneider, Andre Mitschler, A. Joachimiak
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 60:1347-1354
The X-ray crystal structure of human aldose reductase (ALR2) in complex with the inhibitor IDD552 was determined using crystals obtained from two crystallization conditions with different pH values (pH 5 and 8). In both structures the charged carboxy