Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Michael Lee"'
Autor:
Filip Jagodzinski, Milo Rupp, Michael Lee, Jordan D. Valgardson, Jeanine F. Amacher, Robin Cosbey, Paul Houser, Raiden Van Bronkhorst
Publikováno v:
Protein Sci
Recognition of short linear motifs (SLiMs) or peptides by proteins is an important component of many cellular processes. However, due to limited and degenerate binding motifs, prediction of cellular targets is challenging. In addition, many of these
Autor:
Jingqi Wang, Chunping Cui, Yaxin Lu, Yanyu Chang, Yuge Wang, Rui Li, Yilong Shan, Xiaobo Sun, Youming Long, Honghao Wang, Zhanhang Wang, Michael Lee, Shane He, Zhengqi Lu, Wei Qiu, Sha Tan
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
ObjectiveTo explore the outcomes of NMOSD attacks and investigate serum biomarkers for prognosis and severity.MethodPatients with NMOSD attacks were prospectively and observationally enrolled from January 2019 to December 2020 at four hospitals in Gu
Autor:
Vida Abedi, Ming Ta Michael Lee, Marc S. Williams, Josep Bassaganya-Riera, Amy Kolinovsky, Harshit S. Khara, Yanfei Zhang, Alexandria L. Jilg, Jiang Li, Donna M. Wolk, David D. K. Rolston, Raquel Hontecillas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioid
Autor:
Michael Lee, David K. Ann, Derek LeRoith, Hiroyuki Kato, Christine Thai, Angelica Sanchez, Dustin E. Schones, Emily J. Gallagher, Victoria L. Seewaldt, Amy Leung, Parijat Senapati
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-15 (2019)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream effector of insulin, enhances mit
Publikováno v:
Biochemical and Biophysical Research Communications. 513:234-241
Autophagy plays a contradictory role in cell survival and death. Here, we investigated changes in paclitaxel sensitivity of cells with an ATG5 gene-knockout (KO), incapable of synthesizing an E3 ubiquitin ligase necessary for autophagy. The ATG5 KO i
Autor:
John S. Witte, Adem Y. Dawed, Amber A. van der Heijden, Varinderpal Kaur, Nienke van Leeuwen, Yoichiro Kamatani, Leen M 't Hart, Kathleen M. Giacomini, Yanfei Zhang, Ewan R. Pearson, Michiaki Kubo, Jose C. Florez, Yukihide Momozawa, Yu-Chuan Chang, Fei Xu, Federico Innocenti, Amy S. Etheridge, Josephine H. Li, Colin N. A. Palmer, Moneeza K. Siddiqui, Ming Ta Michael Lee, Kaixin Zhou, Roderick C. Slieker, Monique M. Hedderson, Josep M. Mercader, Sook Wah Yee, Joline W. Beulens
Publikováno v:
SSRN Electronic Journal.
Background: Sulfonylureas, the first available drugs for the management of type 2 diabetes, remain widely prescribed today. However there exists significant variability in glycaemic response to treatment. We aimed to establish heritability of sulfony
Autor:
David R. Hill, Ramdane Harouaka, Julie M. Madden, Ebrahim Azizi, Laura S. Rozek, Michael Lee, Max S. Wicha, Shamileh Fouladdel, Justin A. Colacino, Julie L. Boerner, Maureen A. Sartor, Michael D. Brooks, Sean P. McDermott, Michele L. Cote
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 5, Pp 1596-1609 (2018)
Stem Cell Reports, Vol 10, Iss 5, Pp 1596-1609 (2018)
Summary During development, the mammary gland undergoes extensive remodeling driven by stem cells. Breast cancers are also hierarchically organized and driven by cancer stem cells characterized by CD44+CD24low/− or aldehyde dehydrogenase (ALDH) exp
Autor:
Arthur D. Riggs, Defu Zeng, Dustin E. Schones, Yuankun Zhang, Haidong Tang, Ru Feng, Qingxiao Song, Yang-Xin Fu, Kaniel Cassady, Michael Lee
Publikováno v:
Cancer Research. 81:3180-3180
Programmed death ligand 1(PD-L1) has two receptors: programmed death receptor 1 (PD-1) and CD80. Both PD-L1 and CD80 are expressed by activated T-cells, antigen presenting cells (APCs) and tumor cells. Although the role of PD-L1/PD-1 interaction in r
Publikováno v:
Journal of Clinical Medicine
Volume 10
Issue 12
Journal of Clinical Medicine, Vol 10, Iss 2688, p 2688 (2021)
Volume 10
Issue 12
Journal of Clinical Medicine, Vol 10, Iss 2688, p 2688 (2021)
Purpose Polycystic ovary syndrome (PCOS) is a complex disorder with heterogenous phenotypes and unclear etiology. A recent phenotypic clustering study identified metabolic and reproductive subtypes of PCOS. We attempted to deconstruct the PCOS hetero
Autor:
Xueqing Maggie Lu, Gayani Batugedara, Evelien M. Bunnik, Michael Lee, Karine G. Le Roch, Jacques Prudhomme
Publikováno v:
Nucleic Acids Research
Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P. falciparum suggested a cascade of transcriptional activity ov