Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Michael J. Owens"'
Autor:
Boadie W. Dunlop, Mark M. Goodman, Vikram Adhikarla, Jonathon A. Nye, Nashwa Jarkas, Michael J. Owens, Helen S. Mayberg
Publikováno v:
Journal of Nuclear Medicine. 59:315-319
The aim of this study was to measure the test–retest reliability of 11C-N,N-dimethyl-2-(2′-amino-4′-hydroxymethylphenylthio)benzylamine (11C-HOMADAM) imaging of serotonin transporter (SERT) density in healthy control subjects. Methods: Two fema
Autor:
Michael J. Detke, Graeme Eisenhofer, Jill Chappell, Robert A. Dean, Mary Pat Knadler, D. Richard Lachno, Malcolm I. Mitchell, Beth A. Pangallo, Smriti Iyengar, Evelyn D. Lobo, Charles B. Nemeroff, Harry Haber, Michael J. Owens
Publikováno v:
Journal of Clinical Psychopharmacology. 34:9-16
Duloxetine selectively inhibits the serotonin (5-HT) and norepinephrine (NE) transporters (5-HTT and NET, respectively), as demonstrated in vitro and in preclinical studies; however, transporter inhibition has not been fully assessed in vivo at the a
Publikováno v:
Psychoneuroendocrinology. 38:1067-1077
Summary Background The vagus nerve is important in maintaining HPA axis and sympatho-adrenal system (SAS) homeostasis, however little is known about the effect of vagus nerve stimulation (VNS), as used therapeutically, on these functions. Accordingly
Autor:
Gretchen N. Neigh, Michael J. Owens, Christina L. Nemeth, Zachary N. Stowe, Sean D. Kelly, Emily E. Hardy, Chase H. Bourke
Publikováno v:
Physiologybehavior. 172
Prenatal stress has been linked to deficits in neurological function including deficient social behavior, alterations in learning and memory, impaired stress regulation, and susceptibility to adult disease. In addition, prenatal environment is known
Escitalopram is a commonly prescribed antidepressant of the selective serotonin reuptake inhibitor class. Clinical evidence and mapping of the serotonin transporter (SERT) identified that escitalopram, in addition to its binding to a primary uptake-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb36afbaf6241ba1b0cfb30b5f802f2
https://europepmc.org/articles/PMC4724252/
https://europepmc.org/articles/PMC4724252/
Autor:
Zachary N. Stowe, Amanda Nemeroff, James C. Ritchie, Catherine F. Capello, Chase H. Bourke, D. Jeffrey Newport, Michael J. Owens
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 339:275-285
Rigorous data regarding fetal central nervous system (CNS) exposure after antidepressant exposure are sparse. The magnitude of serotonin reuptake inhibitor (SRI) CNS exposure was measured in three groups of rats using ex vivo autoradiography of the s
Autor:
Joan Kaufman, Michael J. Owens, Joel Gelernter, Arie Kaffman, Tarique D. Perera, Eric L. Smith, Charles B. Nemeroff, Chadi G. Abdallah, Leonard A. Rosenblum, Jeremy D. Coplan, Andrew J. Dwork, Jack M. Gorman
Publikováno v:
Psychoneuroendocrinology. 36:289-293
Recent studies have indicated a gene by environment interaction between serotonin transporter gene (5-HTTLPR) polymorphism and childhood abuse on depressive symptoms. In addition, persistent elevation of cerebrospinal fluid (CSF) corticotropin-releas
Autor:
Ping Helen Chen, Lauryn M. Daniel, John R. Votaw, Michael J. Owens, Lawrence E. Williams, Jeffrey S. Stehouwer, Mark M. Goodman, Susan J Plott, Leonard L. Howell, Ronald J. Voll
Publikováno v:
Journal of Medicinal Chemistry. 53:5549-5557
The N-(E)-fluorobutenyl-3beta-(para-halo-phenyl)nortropanes 9-12 were synthesized as ligands of the dopamine transporter (DAT) for use as (18)F-labeled positron emission tomography (PET) imaging agents. In vitro competition binding assays demonstrate
Autor:
Michael J. Owens, Charles B. Nemeroff, Jeffrey S. Stehouwer, Nachwa Jarkas, Clinton D. Kilts, Fanxing Zeng, Mark M. Goodman, Ronald J. Voll
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:783-793
Six new (S,S)-enantiomers of reboxetine derivatives were synthesized and their binding affinities were determined via competition binding assays in cells expressing the human norepinephrine transporter (NET), serotonin transporter (SERT) or dopamine
Autor:
Nachwa Jarkas, Eugene J. Malveaux, Michael J. Owens, Vernon M. Camp, Leonard L. Howell, Ronald Voll, Jeffrey S. Stehouwer, Mark M. Goodman, Larry A Williams, John Votaw, Fanxing Zeng
Publikováno v:
Journal of Medicinal Chemistry. 49:6760-6767
2beta-carbomethoxy-3beta-(3'-((Z)-2-iodoethenyl)phenyl)nortropane (mZIENT, 1) and 2beta-carbomethoxy-3beta-(3'-((Z)-2-bromoethenyl)phenyl)nortropane (mZBrENT, 2) were synthesized and evaluated for binding to the human serotonin, dopamine, and norepin