Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Matthew J. Picklo"'
Publikováno v:
The Journal of Nutrition. 150:1370-1378
BACKGROUND Linoleic acid (LA; 18:2n-6) has been considered to promote low-grade chronic inflammation and adiposity. Studies show adiposity and inflammation are inversely associated with bone mass. OBJECTIVES This study tested the hypothesis that decr
Publikováno v:
The Journal of Nutrition. 150:99-107
BACKGROUND Intake of total fat is linked to obesity and inversely associated with bone density in humans. Epidemiologic and animal studies show that long-chain n-3 (ω-3) PUFAs supplied as fish oil (FO) are beneficial to skeletal health. OBJECTIVE Th
Autor:
Matthew J. Picklo, Michael R. Bukowski, Joseph Idso, Bryan Safratowich, Huawei Zeng, Bret Rust
Publikováno v:
Curr Dev Nutr
OBJECTIVES: Obesogenic, high fat diets (HFD) increase hepatic long chain polyunsaturated fatty acid content (LCPUFA), but also lead to hepatic steatosis and insulin resistance. Fermentable fiber such as inulin (INU) may reduce these negative outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e8fbef349fd0b36672eba557665fd8
https://europepmc.org/articles/PMC7257546/
https://europepmc.org/articles/PMC7257546/
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Frontiers in Oncology
Frontiers in Oncology
Metabolic reprogramming of lipid metabolism is a hallmark of cancer. Consumption of a high-fat obesogenic diet enhances spontaneous metastasis using a Lewis lung carcinoma (LLC) model. In order to gain further insights into the mechanisms by which di
Publikováno v:
Analytical Biochemistry. 469:54-64
Protein S-glutathionylation is a posttranslational modification that links oxidative stimuli to reversible changes in cellular function. Protein–glutathione mixed disulfide (PSSG) is commonly quantified by reduction of the disulfide and detection o
Publikováno v:
Chemico-biological interactions. 253
Levels of obesity in Middle Eastern countries are increasing. Phytochemicals have anti-obesogenic properties as evidenced by prevention of adipocyte differentiation and blocking triacylglyceride (TG) accumulation. In Yemen, Pulicaria jaubertii E. Gam
Publikováno v:
Free Radical Biology and Medicine. 53:690-700
The nuclear factor E2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) pathway responds to oxidative stress via control of several antioxidant defense gene expressions. Recent efforts demonstrate that Nrf2 modulates development of
Publikováno v:
Chemico-Biological Interactions. 191:147-152
Aldehyde dehydrogenase 2 (ALDH2) catalyzes oxidation of toxic aldehydes to carboxylic acids. Physiologic levels of Mg(2+) ions influence ALDH2 activity in part by increasing NADH binding affinity. Traditional fluorescence measurements monitor the blu
Publikováno v:
Free Radical Biology and Medicine. 50:400-407
Alzheimer disease elevates lipid peroxidation in the brain and data indicate that the resulting lipid-aldehydes are pathological effectors of lipid peroxidation. The disposition of 4-substituted nonenals derived from arachidonate (20:4, n-6) and lino
Autor:
Matthew J. Picklo, Ales Honzatko, Rongying Wang, Henry Weiner, Jiri Brichac, Xiaoning Lu, Kwok Ki Ho
Publikováno v:
Chemical Research in Toxicology. 20:887-895
trans-4-Hydroxy-2-nonenal (HNE) is a cytotoxic alpha,beta-unsaturated aldehyde implicated in the pathology of multiple diseases involving oxidative damage. Oxidation of HNE by aldehyde dehydrogenases (ALDHs) to trans-4-hydroxy-2-nonenoic acid (HNEA)