Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Mathur R"'
Autor:
Usha Natraj, C. Sushmitha, Pallavi Sabharwal, Mathur R. N. Murthy, Handanahal S. Savithri, C. K. Amritha
Publikováno v:
Archives of Virology. 165:1163-1176
Monoclonal antibodies have attracted wide attention in therapeutics owing to their high efficacy, low toxicity, and specific targeting. However, antibodies cannot cross the cell membrane barrier. Therefore, their therapeutic potential is limited to s
Publikováno v:
Journal of Structural Biology. 202:118-128
Cellular metabolism of amino acids is controlled by a large number of pyridoxal 5'-phosphate (PLP) dependent enzymes. Diaminopropionate ammonia lyase (DAPAL), a fold type II PLP-dependent enzyme, degrades both the D and L forms of diaminopropionic ac
Autor:
Pallavi Sabharwal, Mathur R. N. Murthy, J. N. Kalyani, Handanahal S. Savithri, G. Deka, Fathima Benazir Jahangir
Publikováno v:
The FEBS journalReferences. 286(18)
A large number of enzymes depend on the ubiquitous cofactor pyridoxal 5 ` phosphate (PLP) for their activity. Pyridoxal kinase (PLK) is the key enzyme involved in the synthesis of PLP from the three forms of vitamin B-6 via the salvage pathway. In th
Autor:
Mathur R. N. Murthy, Ambika M. V. Murthy, Subashini Mathivanan, Handanahal S. Savithri, Sagar Chittori
Publikováno v:
The Lens
Kinases are ubiquitous enzymes that are pivotal to many biochemical processes. There are contrasting views on the phosphoryl-transfer mechanism in propionate kinase, an enzyme that reversibly transfers a phosphoryl group from propionyl phosphate to A
Publikováno v:
Journal of Structural Biology. 189:238-250
In many organisms ``Universal Stress Proteins'' CUSPS) are induced in response to a variety of environmental stresses. Here we report the structures of two USPs, YnaF and YdaA from Salmonella typhimurium determined at 1.8 angstrom and 2.4 angstrom re
Autor:
Paul A.M. Michels, Mikael P Karjalainen, Rajesh K. Harijan, Mathur R. N. Murthy, Rik K. Wierenga, Manfred S. Weiss, Tiila R. Kiema, Neelanjana Janardan
Publikováno v:
Biochemical Journal. 455:119-130
Thiolases are essential CoA-dependent enzymes in lipid metabolism. In the present study we report the crystal structures of trypanosomal and leishmanial SCP2 (sterol carrier protein, type-2)-thiolases. Trypanosomatidae cause various widespread devast
Autor:
Mathur R. N. Murthy, Neelanjana Janardan, Rik K. Wierenga, Handanahal S. Savithri, M. Ithayaraja
Thiolases catalyze the Claisen condensation of two acetyl-CoA molecules to give acetoacetyl-CoA, as well as the reverse degradative reaction. Four genes coding for thiolases or thiolase-like proteins are found in theEscherichia coligenome. In this co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb6a2d05dcf49d27973cea04adfba0b
https://europepmc.org/articles/PMC4933003/
https://europepmc.org/articles/PMC4933003/
Publikováno v:
Biophysical Journal. 110(3)
Pyridoxal kinase (PdxK), a member of ribokinase superfamily of enzymes, is involved in pyridoxal 5’ phosphate (PLP) synthesis by a salvage pathway. PdxK ensures availability of PLP to a large number of enzymes involved in amino acid and sugar metab
Autor:
Pavithra Mukunda, Sathyabalan Murugesan, Usha Natraj, Ambily Abraham, Anjali A. Karande, Ashutosh Gulati, Mathur R. N. Murthy, Handanahal S. Savithri
Publikováno v:
Scientific Reports
The therapeutic potential of antibodies has not been fully exploited as they fail to cross cell membrane. In this article, we have tested the possibility of using plant virus based nanoparticles for intracellular delivery of antibodies. For this purp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923b504136be98b5ac1921bca738108a
Autor:
S.R. Bharath, Farida Khan, J. N. Kalyani, Appaji N. Rao, Mathur R. N. Murthy, S. Bisht, V. Rajaram, Handanahal S. Savithri
Publikováno v:
Journal of Biological Chemistry. 287:20369-20381
Pyridoxal 5'-phosphate (PLP)-dependent enzymes utilize the unique chemistry of a pyridine ring to carry out diverse reactions involving amino acids. Diaminopropionate (DAP) ammonia-lyase (DAPAL) is a prokaryotic PLP-dependent enzyme that catalyzes th