Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Manabu, Igarashi"'
Publikováno v:
PeerJ Physical Chemistry, Vol 3, p e19 (2021)
The substitution of Ile to Val at residue 117 (I117V) of neuraminidase (NA) reduces the susceptibility of the A/H5N1 influenza virus to oseltamivir (OTV). However, the molecular mechanism by which the I117V mutation affects the intermolecular interac
Publikováno v:
PeerJ
PeerJ, Vol 9, p e11552 (2021)
PeerJ, Vol 9, p e11552 (2021)
Background Oseltamivir (OTV)-resistant influenza virus exhibits His-to-Tyr mutation at residue 274 (H274Y) in N1 neuraminidase (NA). However, the molecular mechanisms by which the H274Y mutation in NA reduces its binding affinity to OTV have not been
Autor:
Katherine M Fuller, Erica Ollmann Saphire, Manabu Igarashi, Ayato Takada, Diptiben V. Parekh, Jacob C. Milligan
Publikováno v:
The Journal of Infectious Diseases. 219:415-419
Ebola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, although they are ineffective against other members of the Ebolavirus g
Autor:
Yoshimi Tsuda, Jiro Arikawa, Kumiko Yoshimatsu, Manabu Igarashi, Fumiya Kozawa, Kisho Noda, Kenta Shimizu
Publikováno v:
Viruses
Volume 13
Issue 1
Viruses, Vol 13, Iss 33, p 33 (2021)
Volume 13
Issue 1
Viruses, Vol 13, Iss 33, p 33 (2021)
Severe fever with thrombocytopenia syndrome virus subclone B7 shows strong plaque formation and cytopathic effect induction compared with other subclones and the parental strain YG1. Compared to YG1 and the other subclones, only B7 possesses a single
Autor:
Manabu Igarashi
Publikováno v:
YAKUGAKU ZASSHI. 135:1015-1021
For the prevention and control of infectious viral diseases, vaccines and antiviral drugs targeting viral proteins are of great importance. Amino acid substitutions in viral proteins occasionally cause the emergence of antibody-escape and drug-resist
Autor:
Shinichiro Nakamura, Yasushi Itoh, Misako Nakayama, Kazumasa Ogasawara, Masatoshi Okamatsu, Michiko Doi, Masanori Shiohara, Hiroshi Kida, Yoshihiro Sakoda, Hideaki Ishida, Hirohito Ishigaki, Akihiro Ishii, Naoko Kitagawa, Hideaki Tsuchiya, Manabu Igarashi, Shintaro Shichinohe, Takako Sasamura
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:4962-4973
The number of patients infected with H7N9 influenza virus has been increasing since 2013. We examined the efficacy of neuraminidase (NA) inhibitors and the efficacy of a vaccine against an H7N9 influenza virus, A/Anhui/1/2013 (H7N9), isolated from a
Autor:
Toshiko Kawabata, Eisaburo Deguchi, Makoto Ozawa, Manabu Igarashi, Aya Matsuu, Kouki Yonezawa, Akira Taneno, Kyoko Tsukiyama-Kohara, Kosuke Okuya, Kimihito Ito
Publikováno v:
Journal of Clinical Microbiology
The control of swine influenza virus (SIV) infection is paramount for increasing the productivity of pig farming and minimizing the threat of pandemic outbreaks. Thus, SIV surveillance should be conducted by region and on a regular basis. Here, we es
Autor:
Naganori Nao, Junya Yamagishi, Hiroko Miyamoto, Manabu Igarashi, Rashid Manzoor, Aiko Ohnuma, Yoshimi Tsuda, Wakako Furuyama, Asako Shigeno, Masahiro Kajihara, Noriko Kishida, Reiko Yoshida, Ayato Takada, Mary K. Estes
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
mBio, Vol 8, Iss 1, p e02298-16 (2017)
mBio
mBio, Vol 8, Iss 1, p e02298-16 (2017)
mBio
Highly pathogenic avian influenza viruses with H5 and H7 hemagglutinin (HA) subtypes evolve from low-pathogenic precursors through the acquisition of multiple basic amino acid residues at the HA cleavage site. Although this mechanism has been observe
Autor:
Ayato Takada, Keita Matsuno, Makoto Kuroda, Manabu Igarashi, Osamu Noyori, Eri Nakayama, Reiko Yoshida, Masahiro Kajihara, Norikazu Isoda
Publikováno v:
Virology. 446(1-2):152-161
The viral envelope glycoprotein (GP) is thought to play important roles in the pathogenesis of filovirus infection. It is known that GP expressed on the cell surface forms a steric shield over host proteins such as major histocompatibility complex cl
Autor:
Kimihito Ito, Yoshihiro Kawaoka, Ryo Takano, Masakazu Sekijima, Ayato Takada, Maki Kiso, Manabu Igarashi, Quynh Mai Le
Publikováno v:
The Journal of Infectious Diseases. 207:89-97
Background. The neuraminidase (NA) inhibitor oseltamivir is widely used to treat patients infected with influenza viruses. An Ile-to-Val change at position 117 in influenza A virus subtype H5N1 NA (NA-I117V) confers a reduction in susceptibility to o