Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Majer A"'
Autor:
Dan Su, Kyle M. Lancaster, Sean H. Majer, Rachael E. Coleman, Michael K. Fenwick, Brian R. Crane, Siddarth Chandrasekaran, Jack H. Freed, Boris Dzikovski, Hening Lin, Yugang Zhang
Publikováno v:
Journal of the American Chemical Society
All radical S-adenosylmethionine (radical-SAM) enzymes, including the noncanonical radical-SAM enzyme diphthamide biosynthetic enzyme Dph1–Dph2, require at least one [4Fe–4S](Cys)3 cluster for activity. It is well-known in the radical-SAM enzyme
Autor:
Jiří Brynda, Ullrich Jahn, Milan Potáček, Anna Hlavačková, Vlastimil Král, M. Kugler, Pavlína Řezáčová, Jiří Schimer, Milan Dejmek, Pavel Šácha, Jan Tykvart, Jan Konvalinka, Lukáš Tenora, Václav Navrátil, Jitka Zemanova, Pavel Majer
Publikováno v:
SLAS Discovery. 25:1026-1037
The DNA-linked inhibitor antibody assay (DIANA) has been recently validated for ultrasensitive enzyme detection and for quantitative evaluation of enzyme inhibitor potency. Here we present its adaptation for high-throughput screening of human carboni
Autor:
W. David Church, Dennis Wegener, Tim J. Wigle, Arne Brendes, Kevin Wayne Kuntz, Demet Aybar, Paul Chang, Melissa Vasbinder, Claudia Beck, Martin Prahm, Kerren Kalai Swinger, Laurie B. Schenkel, Christina R. Majer
Publikováno v:
Slas Discovery
Mono(ADP-ribosylation) (MARylation) and poly(ADP-ribosylation) (PARylation) are posttranslational modifications found on multiple amino acids. There are 12 enzymatically active mono(ADP-ribose) polymerase (monoPARP) enzymes and 4 enzymatically active
Publikováno v:
Nature, vol 575, iss 7782
Nature
Nature
Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate the recognition of microbial DNA and RNA while limiting the recognition of an organism's own nucleic acids1. Failure to properly regulate these TLRs can l
Publikováno v:
Membranes
Volume 11
Issue 10
Membranes, Vol 11, Iss 783, p 783 (2021)
Volume 11
Issue 10
Membranes, Vol 11, Iss 783, p 783 (2021)
Fibrin membranes are widely used in regenerative medicine because they are biocompatible, biodegradable, contain growth factors, and support cell attachment. Most commonly they are produced from serum, but they can also be isolated from activated pla
Autor:
Werner Höllriegl, Bernhard Majer, Peter Leidenmühler, Paolo Rossato, Maria Schuster, Friedrich Scheiflinger, Alexandra Kopic, Tanja Ruthsatz, Helmut Glantschnig
Publikováno v:
Blood Coagulation & Fibrinolysis
Insufficiency of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin motif repeats-13) is the cause of thrombotic thrombocytopenic purpura (TTP) and contributes in microangiopathy in sickle cell disease (SCD). Recombinant ADAMTS13 effecti
Autor:
Martin Dračínský, Aleš Machara, Milan Kožíšek, Pavel Majer, Robert Reiberger, Jiří Brynda, Václav Zima, Kateřina Radilová, Michal Kráľ, Jan Konvalinka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7735, p 7735 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences
Volume 22
Issue 14
The part of the influenza polymerase PA subunit featuring endonuclease activity is a target for anti-influenza therapies, including the FDA-approved drug Xofluza. A general feature of endonuclease inhibitors is their ability to chelate Mg2+ or Mn2+ i
Autor:
Thomas Hachenberg, Monika C. Brunner-Weinzierl, Florian Prätsch, Ulrike Billing, Dirk Reinhold, Holger Lingel, Christoph Thurm, Stefan Meltendorf, Christiane Majer, Dirk Roggenbuck, Eugen Feist, Hans Gert Heuft, Katrin Vogel
Publikováno v:
Journal of Autoimmunity
The variability in resolution of SARS-CoV-2-infections between individuals neither is comprehended, nor are the long-term immunological consequences. To assess the long-term impact of a SARS-CoV-2-infection on the immune system, we conducted a prospe
Publikováno v:
Chemical Science. 10:3756-3764
Ammonia oxidizing bacteria (AOB) use the cytotoxic, energetic molecule hydroxylamine (NH2OH) as a source of reducing equivalents for cellular respiration. Despite disproportionation or violent decomposition being typical outcomes of reactions of NH2O
Autor:
Jiri Vondrasek, Monika Zouharova, Lenka Monincová, Klara Postulkova, Ivan Barvík, Kateřina Hofbauerová, Petr Herman, Pavel Majer, Veronika Vetyskova, Kristyna Bousova
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4323, p 4323 (2020)
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4323, p 4323 (2020)
Molecular determinants of the binding of various endogenous modulators to transient receptor potential (TRP) channels are crucial for the understanding of necessary cellular pathways, as well as new paths for rational drug designs. The aim of this st