Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Lin Zhao"'
Publikováno v:
Acta Pharmacol Sin
Large amounts of tumor-associated macrophages (TAM), which are predominately localized in hypoxia area of the tumor tissue, are associated with the malignant progression of the tumor. In the present study, we investigated the inhibitory effects of mo
Publikováno v:
Biochemical and Biophysical Research Communications. 548:78-83
Targeting the dimer interface for the epidermal growth factor receptor (EGFR) that is highly conserved in the structure and directly involved in dimerization may solve the resistance problem that plagues anti-EGFR therapy. Heavy chain single domain a
Autor:
Yueshuo Li, Feng Shi, Jia Fan, Xin Zhang, Weihua Liao, Xiangjian Luo, Qiang Gao, Na Liu, Hui Zheng, Ann M. Bode, Min Tang, Min Zhou, Longlong Xie, Ya Cao, Jianmin Hu, Shuang-Jian Qiu, Mao Ye, Lin Zhao, Wei-Zhong Wu, Jian Zhou
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-14 (2021)
NPJ Precision Oncology
NPJ Precision Oncology
p18 is a key negative regulator of cell cycle progression and mediates cell cycle arrest at the G1/S phase. Ubiquitination is the prime mechanism in regulating p18 protein abundance. However, so far no post- translational regulator, especially DUBs,
Autor:
Yuanming Sun, Song Huang, Juewen Liu, Zhen-Lin Xu, Jin-Lin Zhao, Zhicheng Huang, Zi-Jian Chen
Publikováno v:
The Analyst. 146:864-873
Having the benefits of low cost, excellent stability and tolerance to extreme conditions, nanozymes are a potential alternative of horseradish peroxidase (HRP) or other enzymes for bioanalytical chemistry, especially immunoassays. CeO2 nanoparticles
Publikováno v:
Chinese Medical Journal
Chinese Medical Journal, Vol 133, Iss 18, Pp 2177-2185 (2020)
Chinese Medical Journal, Vol 133, Iss 18, Pp 2177-2185 (2020)
Supplemental Digital Content is available in the text
Background Developing effective spinal cord repair strategies for spinal cord injury (SCI) is of great importance. Emerging evidence suggests that microRNAs (miRNAs) are closely linked to SCI
Background Developing effective spinal cord repair strategies for spinal cord injury (SCI) is of great importance. Emerging evidence suggests that microRNAs (miRNAs) are closely linked to SCI
Publikováno v:
Gastroenterology Report
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide and 30% of patients with CRC experience metastasis. Patients with metastatic colorectal cancer (mCRC) have a 5-year overall survival rate of
Autor:
Qi Yating, Chao Deng, Yuehu Han, Lin Zhao, Baoping Xu, Zheng Wang, Zhi Yang, Xue Wu, Yang Yang, Wenwen Yang, Ting Ji
Publikováno v:
Journal of Cellular Physiology. 235:9121-9132
Chemokines constitute a superfamily of small chemotactic cytokines with functions that are based on interactions with their corresponding receptors. It has been found that, among other functions, chemokines regulate the migratory and invasive abiliti
Publikováno v:
Metabolic Brain Disease. 35:959-970
Paeoniflorin is a natural monoterpene glucoside from Paeoniae Radix with neuroprotective properties. However, it is still unclear whether paeoniflorin has neuroprotective effects on subarachnoid hemorrhage (SAH). This study explores the effect of pae
Autor:
Stefan Roepcke, Grace Chen, Eric R. Fedyk, Annelize Koch, Glennda Smithson, Lin Zhao, Jose Estevam, Lachy McLean, Jianchang Lin, Gezim Lahu
Publikováno v:
British Journal of Clinical Pharmacology
Aims This investigation characterised tolerability, pharmacokinetics and pharmacodynamics of the anti-CD38 antibody TAK-079. Methods A randomised, double-blind, placebo-controlled trial of a single intravenous (i.v.) infusion or subcutaneous (s.c.) i
Autor:
Li Wang, Ran Wei, Zhaoxia Wang, Yunhong Zhang, Zhen Zhang, Xianbin Zhou, Xiaoxiao Zhu, Haiping Liu, Chu Chu, Qiang Guo, Xia Li, Lin Zhao
Publikováno v:
International Journal of Biological Sciences
Recurrent spontaneous abortion (RSA) is a common complication of early pregnancy. Excessive M1 macrophage was found to be involved in RSA, but the underlying mechanisms remains unclear. MicroRNAs play critical roles in RSA as well as the polarization