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Publikováno v:
Biomacromolecules. 21:3644-3657
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated cytosine-phosphate-guanine (CpG) motifs trigger the immune response by stimulating endosomal Toll-like receptor (TLR) 9. Natural linear ODNs are susceptible to nuclease degradation, there
Autor:
Yuuki Sugiyama, Wakako Tsugawa, Koji Sode, Kaori Tsukakoshi, Tomohiko Yamazaki, Kazunori Ikebukuro, Kazuaki Hoshi
Publikováno v:
Nucleic Acid Therapeutics. 29:224-229
Single-strand oligodeoxynucleotides (ODNs) containing unmethylated cytosine-phosphate-guanine (CpG) are recognized by the toll-like receptor 9, a component of the innate immunity. Therefore, they could act as immunotherapeutic agents. Chemically modi