Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Katsunori Iwasaki"'
Autor:
Tomohisa Nagamatsu, Norio Akaike, Kaori Kubota, Takuya Watanabe, Shutaro Katsurabayashi, Kohei Oyabu, Katsunori Iwasaki
Publikováno v:
Biochemical and biophysical research communications. 560
Adenosine triphosphate (ATP) is the most vital energy source produced mainly in the mitochondria. Age-related mitochondrial dysfunction is associated with brain diseases. Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for energy pr
Autor:
Kaori Kubota, Haruka Fukue, Hitomi Sato, Kana Hashimoto, Aya Fujikane, Hiroshi Moriyama, Takuya Watanabe, Shutaro Katsurabayashi, Mosaburo Kainuma, Katsunori Iwasaki
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Frontiers in Pharmacology
Frontiers in Pharmacology
Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer dise
Autor:
Michihiro Fujiwara, Çağdaş Erdoğan, Katsunori Iwasaki, Shin Ishikane, Takuya Watanabe, Mehmet Bülent Özdemir
Publikováno v:
Neurological Research. 35:798-803
Objectives: Because of the well-known neurochemical interactions between the septum and hippocampus during memory processes, we investigated the effect of amyloid-beta (A-beta) injection into the medial septum (MS) on the behavior in Wistar rats. We
Autor:
Shutaro Katsurabayashi, Kotaro Takasaki, Miyuki, Kaori Kubota, Sachiko Nakano, Katsunori Iwasaki, Kenichi Mishima, Chihiro Tatsumi, Hiroyuki Kawano, Michihiro Fujiwara
Publikováno v:
Physiological Reports
Amyloid precursor protein (APP), a type I transmembrane protein, has different aspects, namely, performs essential physiological functions and produces β‐amyloid peptide (Aβ). Overexpression of neuronal APP is responsible for synaptic dysfunction
Autor:
Tamami Haraguchi, Katsunori Iwasaki, Tetsuya Naito, Kazuhide Hayakawa, Michihiro Fujiwara, Shutaro Katsurabayashi, Kenichi Mishima, Kotaro Takasaki
Publikováno v:
Neuroscience Letters. 464:151-155
Telmisartan is known to block angiotensin (Ang) II type-1 receptors (AT(1)R), and also activate peroxisome proliferator-activated receptor gamma (PPARgamma) signaling. Recently, PPARgamma has been implicated as a regulator of cellular proliferation a
Autor:
Takuya Watanabe, Shutaro Katsurabayashi, Kenichi Mishima, Kotaro Takasaki, Kazunori Sano, Katsunori Iwasaki, Nobuaki Egashira, Kazuhide Hayakawa, Michihiro Fujiwara, Norito Yamagata
Publikováno v:
Brain Research. 1249:222-228
Acetylcholine (ACh) release is one of the key factors in memory mechanisms. To clarify whether beta-amyloid (Aβ) induces a disturbance of the cholinergic system leading to memory impairment, we examined memory impairment and measured hippocampal ACh
Autor:
Kensuke Orito, Masayuki Fujioka, Keiichi Irie, Mai Hazekawa, Shutaro Katsurabayashi, Nobuaki Egashira, Michihiro Fujiwara, Shohei Mishima, Katsunori Iwasaki, Kazuhide Hayakawa, Kotaro Takasaki, Kenichi Mishima
Publikováno v:
Neuropharmacology. 55:1280-1286
We examined the cerebroprotective mechanism of cannabidiol, the non-psychoactive component of marijuana, against infarction in a 4-h mouse middle cerebral artery (MCA) occlusion model. Cannabidiol was intraperitoneally administrated immediately befor
Autor:
Kazuhide Hayakawa, Keiichi Irie, Michihiro Fujiwara, Kenichi Mishima, Masanori Nozako, Mai Hazekawa, Kensuke Orito, Kohji Abe, Nobuaki Egashira, Nobuyoshi Hasebe, Katsunori Iwasaki, Masayuki Fujioka
Publikováno v:
Journal of Neurochemistry. 102:1488-1496
We examined the neuroprotective mechanism of cannabidiol, non-psychoactive component of marijuana, on the infarction in a 4 h mouse middle cerebral artery (MCA) occlusion model in comparison with Delta(9)-tetrahydrocannabinol (Delta(9)-THC). Release
Autor:
Nobuaki Egashira, Megumi Osajima, Michihiro Fujiwara, Ryozo Oishi, Kazuhide Hayakawa, Kenichi Mishima, Katsunori Iwasaki
Publikováno v:
Journal of Pharmacological Sciences, Vol 105, Iss 2, Pp 211-214 (2007)
We investigated the involvement of γ-aminobutyric acidA (GABAA) receptors in the neuroprotective effect of γ-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine
Autor:
Kenichi Mishima, Izzettin Hatip-Al-Khatib, Michihiro Fujiwara, Daisuke Ishibashi, Katsunori Iwasaki, Nobuaki Egashira
Publikováno v:
Journal of Pharmacological Sciences, Vol 103, Iss 1, Pp 83-91 (2007)
In addition to their role in physiological activities, ionotropic glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPARs) play an important role in neuronal death, especially that following ischemic insults. In this study, we