Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Karel Souček"'
Autor:
Vondálová Blanářová O, Karel Souček, Michaela Nosková, Víchová R, Kristína Gömöryová, Gybel’ T, Zbynek Zdrahal, Karol Kaiser, Lucia Kucerova, Lucia Demkova, Bryja, David Potěšil, Katarzyna Anna Radaszkiewicz, Markéta Pícková, Tomasz Witold Radaszkiewicz
RNF43 is a E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopreci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::259dd6982413886159ca97f70622272a
https://doi.org/10.1101/2021.02.08.430210
https://doi.org/10.1101/2021.02.08.430210
Autor:
Jan Bouchal, Wytske M. van Weerden, Vladimír Študent, Zoran Culig, Martin Morong, Stanislav Drápela, Daniela Kurfürstová, Barbora Kvokackova, Radek Fedr, Martin Puhr, Karel Souček
BackgroundDocetaxel resistance represents a leading obstacle in the therapy of prostate cancer (PCa), resulting in lethal disease. Intratumoral heterogeneity, which is frequently driven by epithelial-mesenchymal plasticity significantly contributes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06e0a02611c88c6759b3e22b9c27403
https://doi.org/10.1101/2021.01.28.428577
https://doi.org/10.1101/2021.01.28.428577
Autor:
Zbyněk Zdráhal, Olga Vondálová Blanářová, Tomáš Gybeľ, Markéta Pícková, Lucia Kucerova, Ráchel Víchová, Kristína Gömöryová, Tomasz Witold Radaszkiewicz, Karol Kaiser, Vítězslav Bryja, David Potěšil, Tomáš Bárta, Michaela Nosková, Karel Souček, Lucia Demkova, Katarzyna Anna Radaszkiewicz
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopr
Autor:
Zuzana Kahounová, Petr Beneš, Ján Remšík, Jiřina Procházková, Jan Bouchal, Tereza Suchankova, Gvantsa Kharaishvili, Karel Souček, Milan Král, Radek Fedr, Eva Slabáková, Šárka Šimečková
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Skp2 is a crucial component of SCFSkp2 E3 ubiquitin ligase and is often overexpressed in various types of cancer, including prostate cancer (PCa). The epithelial-to-mesenchymal transition (EMT) is involved in PCa progression. The acquisition of a mes
Autor:
Zdeněk Andrysík, Radek Fedr, Josef Mašek, Miroslav Machala, Jan Topinka, Eva Hrubá, Simona Strapáčová, Lucie Svržková, Ondřej Vacek, Martina Hýžďalová, Jiří Kléma, Karel Souček, Jiřina Procházková, Jan Vondráček, Helena Libalova
Publikováno v:
Chemosphere. 263:128126
Deciphering the role of the aryl hydrocarbon receptor (AhR) in lung cancer cells may help us to better understand the role of toxic AhR ligands in lung carcinogenesis, including cancer progression. We employed human lung carcinoma A549 cells to inves
Autor:
Jason P. Eiserich, Tomas Perecko, Stephan Baldus, Silvie Kremserová, Lukáš Kubala, Anna Klinke, Karel Souček
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Systemic inflammation accompanying diseases such as sepsis affects primarily lungs and induces their failure. This remains the most common cause of sepsis induced mortality. While neutrophils play a key role in pulmonary failure, the mechanisms remai
Autor:
Peter Kollar, Tatiana Syrovets, Tereza Kauerová, Radek Fedr, Tomáš Goněc, Ann-Kathrin Gaiser, Karel Souček, Josef Jampilek, Susanne Hafner
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3416, p 3416 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 10
International Journal of Molecular Sciences
Volume 21
Issue 10
Ring-substituted 1-hydroxynaphthalene-2-carboxanilides were previously investigated for their antimycobacterial properties. In our study, we have shown their antiproliferative and cell death-inducing effects in cancer cell lines. Cell proliferation a
Autor:
Rastislav Jendželovský, Radek Fedr, Jaromír Mikeš, Karel Souček, Peter Fedoročko, Alois Kozubík, Lucia Mikešová, Barbora Kuchárová, Ján Remšík, Ľubomír Čulka, Jana Vargová
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 99
Objective Cancer stem-like cells (CSLCs) are considered a root of tumorigenicity and resistance. However, their identification remains challenging. The use of the side population (SP) assay as a credible marker of CSLCs remains controversial. The SP
Autor:
Martin Mistrik, Radek Fedr, Ondřej Hylse, Jiří Kohoutek, Šárka Šimečková, Kamil Paruch, Juraj Kramara, Hana Paculová, Karel Souček, Marek Svoboda
Publikováno v:
Tumor Biology, Vol 39 (2017)
A broad spectrum of tumors develop resistance to classic chemotherapy, necessitating the discovery of new therapies. One successful strategy exploits the synthetic lethality between poly(ADP-ribose) polymerase 1/2 proteins and DNA damage response gen
Publikováno v:
Scopus-Elsevier
We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with