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pro vyhledávání: '"Jonathan Chu"'
Autor:
Abhisek Bhattacharya, Alfred Singer, Jinghua Lu, Ingrid Saba, Jonathan Chu, Peter D. Sun, François Van Laethem, Anastasia N. Tikhonova
Publikováno v:
J Immunol
During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide–MHC ligands together with CD4/CD8 coreceptors. Conversely, in MHC and CD4/CD8 coreceptor-deficient mice,
Autor:
Tomer Arnon, Marco Craveiro, Nicholas C. Love, Sergei Radaev, Nan-ping Weng, Abhisek Bhattacharya, Xiaoping Sun, Jonathan Chu, Jinghua Lu, Nir Friedman, Ingrid Saba, Eric Shifrut, Anastasia N. Tikhonova, Alfred Singer, Annette Ko, Peter D. Sun, François Van Laethem
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The αβ T cell receptor (TCR) repertoire on mature T cells is selected in the thymus, but the basis for thymic selection of MHC-restricted TCRs from a randomly generated pre-selection repertoire is not known. Here we perform comparative repertoire s
Publikováno v:
Proceedings of the National Academy of Sciences. 112:833-838
Fc gamma receptor I (FcγRI) contributes to protective immunity against bacterial infections, but exacerbates certain autoimmune diseases. The sole high-affinity IgG receptor, FcγRI plays a significant role in immunotherapy. To elucidate the molecul