Zobrazeno 1 - 10
of 14
pro vyhledávání: '"James T. Koerber"'
Autor:
James T. Koerber, Tracy Staton, Tangsheng Yi, Meire Bremer, Henry R. Maun, Saloumeh K Fischer, Robert A. Lazarus, Gizette Sperinde, Amos Baruch, Rajesh Vij
Publikováno v:
Bioanalysis. 12:1377-1388
Aim: Tryptase is a tetrameric trypsin-like serine protease contained within the secretory granules of mast cells and is an important mediator of allergic inflammatory responses in respiratory diseases. Detection of active tryptase in the airway may p
Autor:
Scott C. Rosenberg, James T. Koerber, Christopher M. Rose, Donald S. Kirkpatrick, Simon E. Vidal, Andrey S. Shaw, Ingrid E. Wertz, Trent Hinkle, Lilian Phu, Frances-Rose Schumacher, Andrew S. Peterson, Yi Zeng, Carsten Schwerdtfeger, Jennie R. Lill, Jawahar Sudhamsu, Christopher W. Davies
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The ubiquitin conjugating enzyme UBE2W catalyzes non-canonical ubiquitination on the N-termini of proteins, although its substrate repertoire remains unclear. To identify endogenous N-terminally-ubiquitinated substrates, we discover four monoclonal a
Autor:
Irma B. Stowe, James T. Koerber, Aaron Gupta, Qui T. Phung, Hoangdung Ho, Jian Payandeh, Yingnan Zhang, Nobuhiko Kayagaki, Corey E. Bakalarski, Jennie R. Lill, Christopher W. Davies
Publikováno v:
Proc Natl Acad Sci U S A
Inflammasomes sense a number of pathogen and host damage signals to initiate a signaling cascade that triggers inflammatory cell death, termed pyroptosis. The inflammatory caspases (1/4/5/11) are the key effectors of this process through cleavage and
Autor:
Lionel Rouge, Christopher M. Koth, Tristan I. Croll, Alberto Estevez, Nan Chiang, James T. Koerber, Christine Tam, Claudio Ciferri, Alexis Rohou, Micah Steffek, Christopher P. Arthur, Jian Payandeh, Christine Kugel, Gerald R. Nakamura, Edward Kraft
Clustering for the kill Cluster of differentiation 20 (CD20) is a membrane protein that defines most B cell populations and is the target of therapeutic antibodies to treat malignancies and autoimmune disorders. Rougé et al. present the structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365fe2b4f1a6b03e7e34c9811c43a113
https://www.repository.cam.ac.uk/handle/1810/314934
https://www.repository.cam.ac.uk/handle/1810/314934
Autor:
Jason Ho, Christopher W. Davies, Hanine Rafidi, C. Andrew Boswell, Shang-Fan Yu, Lidia A. Nazarova, Sheila Ulufatu, James T. Koerber, Danielle Mandikian, Jeffrey Lau, Gregory Z. Ferl, Jack Sadowsky, James A. Ernst
Publikováno v:
Molecular cancer therapeutics. 19(4)
Full-length antibodies lack ideal pharmacokinetic properties for rapid targeted imaging, prompting the pursuit of smaller peptides and fragments. Nevertheless, studying the disposition properties of antibody-based imaging agents can provide critical
Autor:
Kelly M. Loyet, Neil N. Trivedi, Racquel Corpuz, Brian L. Yaspan, Tracy Staton, Henry R. Maun, Erin H. Christensen, Kathila R. Alatsis, Xiumin Wu, Michael T. Lipari, Yvonne Franke, Mark S. Dennis, Daniel Kirchhofer, Wyne P. Lee, Rahul Ahuja, Xiaocheng Chen, Ashley Morando, Diana Chang, James T. Koerber, Aija Kusi, Joseph R. Arron, John Liu, Guiquan Jia, Juan Zhang, Janet Jackman, Ping Wu, George H. Caughey, Yan Wu, Rajesh Vij, Luz D. Orozco, Lawrence B. Schwartz, Benjamin T. Walters, Charles Eigenbrot, Prescott G. Woodruff, Lawren C. Wu, David F. Choy, Robert A. Lazarus, Meire Bremer, Amy Dressen, Magda Babina, Tangsheng Yi, Savita Ubhayakar, Xiaorong Liang, Jeff Lutman, Siddharth Sukumaran, Jason A. Hackney, John V. Fahy, Julie Q. Hang, Cary D. Austin, Manda Wong
Publikováno v:
Cell, vol 179, iss 2
Cell
Cell
Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and have significant unmet medical needs. We show that mast cell tryptase is elevated in severe asthma patients, correlating wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c0946c02d2066eb05676694e454e0e
https://escholarship.org/uc/item/8pf5p52n
https://escholarship.org/uc/item/8pf5p52n
Autor:
Jean-Michel Vernes, Kellen Schneider, Christopher M. Koth, Y. Gloria Meng, Rajesh Vij, Jianping Yin, Peter A. S. Smith, Kelly M. Storek, Jian Payandeh, Steven T. Rutherford, Laetitia Comps-Agrar, Zhonghua Lin, Dhaya Seshasayee, Stephanie Shriver, Heidi J.A. Wallweber, Nan Chiang, Joyce Chan, Jack Bevers, Gerald R. Nakamura, Olivier Dalmas, Christine Tam, James T. Koerber
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Outer membrane proteins (OMPs) in Gram-negative bacteria dictate permeability of metabolites, antibiotics, and toxins. Elucidating the structure-function relationships governing OMPs within native membrane environments remains challenging. We constru
Autor:
Nan Chiang, James T. Koerber, Jian Payandeh, Jean-Michel Vernes, Zhonghua Lin, Jianping Yin, Kellen Schneider, Christine Tam, Jack Bevers, Heidi J.A. Wallweber, Kelly M. Storek, Peter A. S. Smith, Laetitia Comps-Agrar, Y. Gloria Meng, Rajesh Vij, Christopher M. Koth, Steven T. Rutherford, Stephanie Shriver, Dhaya Seshasayee, Joyce Chan, Gerald R. Nakamura, Olivier Dalmas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d76eb8915ea0bb83e2e33a071d35fa2
https://doi.org/10.7554/elife.46258.022
https://doi.org/10.7554/elife.46258.022
Autor:
Peter A. S. Smith, Christine Tam, Steven T. Rutherford, Kelly M. Storek, Joyce Chan, Inna Zilberleyb, Gerald R. Nakamura, Jean-Michel Vernes, Avinash Gill, Peng Luan, Sophia Lee, Zhonghua Lin, James T. Koerber, Dhaya Seshasayee, Min Xu, Laetitia Comps-Agrar, Kellen Schneider, Jian Payandeh, Y. Gloria Meng, Rajesh Vij, Marcy R. Auerbach, Jack Bevers, Summer Park, Nan Chiang, Christopher M. Koth
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Outer membrane proteins (OMPs) in Gram-negative bacteria are essential for a number of cellular functions including nutrient transport and drug efflux. Escherichia coli BamA is an essential component of the OMP β-barrel assembly machinery and a pote
Autor:
Amy L. Shelton, Ji Li, Rodney A. Prell, Jennifer Johnston, Christoph Spiess, Genee Lee, Kapil Gadkar, James T. Koerber, Amy C. Y. Lo, Klara Totpal, Diego Ellerman, Teemu T. Junttila, T. Noelle Lombana, Maria Hristopoulos, Elaine Mai, Robyn Clark, Dionysos Slaga, Rajesh Vij
Publikováno v:
Science translational medicine. 10(463)
A primary barrier to the success of T cell-recruiting bispecific antibodies in the treatment of solid tumors is the lack of tumor-specific targets, resulting in on-target off-tumor adverse effects from T cell autoreactivity to target-expressing organ