Zobrazeno 1 - 10
of 127
pro vyhledávání: '"James A. Brown"'
Autor:
James C. Moon, Peter Kellman, Robert G. Bell, George Thornton, Yousuf Razvi, Thomas A. Treibel, Paramjit S. Jeetley, Gabriella Captur, Clare Coyle, Liza Chacko, Luke Howard, Abhishek Shetye, Anthony Wolff, Michael Jacobs, Toby Hillman, Rupert Negus, Hui Xue, Onn Min Kon, Meg Coleman, Daniel S Knight, Tushar Kotecha, Jamil Mayet, Melissa Heightman, Georgina Russell, Kavitha Vimalesvaran, Ben Ariff, Palmira Mathurdas, Niket Patel, Marianna Fontana, Donald Leith, James T Brown, Lucy E Lamb, Deepa Gopalan, Charlotte Manisty, Graham D. Cole, Iain Pierce, J. G. Goldring, Prapa Kanagaratnam, Rishi K Patel, Kartik Kumar
Publikováno v:
European Heart Journal. 42:1866-1878
Background Troponin elevation is common in hospitalized COVID-19 patients, but underlying aetiologies are ill-defined. We used multi-parametric cardiovascular magnetic resonance (CMR) to assess myocardial injury in recovered COVID-19 patients. Method
Autor:
Olga Timofeeva, James D.J. Brown
Publikováno v:
Indian J Thorac Cardiovasc Surg
Lung transplant outcomes remain inferior largely due to mismatching in human leukocyte antigens (HLAs) that leads to chronic rejection and chronic allograft dysfunction. The mismatched donor HLAs can be recognized by the effector T cells or donor-spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ae3bb208061d427fa3e9e6775ef129
https://europepmc.org/articles/PMC9226257/
https://europepmc.org/articles/PMC9226257/
Autor:
Jess Savas, Hafiz S. Patwa, James A. Brown, Laura Doerfler, Kimberly M. Burcher, Phillip Williford, Christopher A. Sullivan, Joshua D. Waltonen, Mercedes Porosnicu, Nate Bowers
Publikováno v:
Regular and young investigator award abstracts.
Background PD-1 inhibitors were approved for locally advanced and metastatic cutaneous squamous cell carcinoma (CSCC) in 2019.1 The identification of tumor characteristics that predict potential responders to immune checkpoint inhibitors (ICI) is an
Autor:
Lyse A. Norian, Rohan Garje, Lewis Thomas, Shannon K. Boi, Rebecca C. Arend, Claire Buchta Rosean, Brett P. Gross, Lakshminarayanan Nandagopal, David M. Lubaroff, Rachael M. Orlandella, Kenneth G. Nepple, Dmytro Starenki, William J. Turbitt, George J. Weiner, Katlyn E Norris, Gal Wald, Kristine I Farag, Megan Bing, Eddy S. Yang, Jennifer B. Gordetsky, Robert E. Sorge, Amani Makkouk, Hesham A Yasin, James A. Brown, Peng Li, Justin T. Gibson, Tatiana T. Marquez-Lago, Yousef Zakharia, Laura A. Bertrand, Aliasger K. Salem
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundObesity is a major risk factor for renal cancer, yet our understanding of its effects on antitumor immunity and immunotherapy outcomes remains incomplete. Deciphering these associations is critical, given the growing clinical use of immune
Autor:
Rebecca D. Dodd, Marion Vanneste, Michael B. Cohen, Patrick Breheny, Wade R. Gutierrez, James A. Brown, Michael D. Henry, Devon L. Moose, Nadine Bannick, Courtney Yong, Robert U. Svensson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0232807 (2020)
PLoS ONE, Vol 15, Iss 9, p e0232807 (2020)
Here we have improved an existing mouse model of prostate cancer based on prostate-specific deletion of Pten and Trp53 by incorporating a Cre-activatable luciferase reporter. By coupling the deletion of those genes to the activation of a luciferase r
Autor:
James A. Brown
Publikováno v:
Pharmaceutical patent analyst. 9(1)
Lysine (or histone) acetyltransferases plays a key role in genome maintenance and gene regulation and dysregulation of acetylation is a recognized feature of many diseases, including several cancers. Here, the patent landscape surrounding lysine acet
Autor:
Anthony Wolff, Michael Jacobs, Liza Chacko, Yousuf Razvi, Daniel S Knight, Paramjit S. Jeetley, James C. Moon, Peter Kellman, Marianna Fontana, Rupert Negus, James T Brown, Lucy E Lamb, Tushar Kotecha, J. G. Goldring, Niket Patel, Hui Xue
Publikováno v:
Circulation
Background: Hospitalised COVID-19 patients frequently have acute myocardial injury with elevated troponin levels Underlying aetiologies are ill-defined We use
Publikováno v:
Biochemical Society Transactions
Two opposing enzyme classes regulate fundamental elements of genome maintenance, gene regulation and metabolism, either through addition of an acetyl moiety by histone acetyltransferases (HATs) or its removal by histone de-acetyltransferases (HDAC),
Autor:
Devon L. Moose, Marion Vanneste, James A. Brown, Nadine Bannick, Michael B. Cohen, Michael D. Henry, Courtney Yong
Publikováno v:
Journal of Urology. 201
Publikováno v:
Stroke. 50
Introduction: Acute brain infarcts can provoke functional and morphologic changes in internal organs in the absence of primary visceral causes. We tested the hypothesis that infarcts in certain regions of the brain were much more likely to be associa