Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Hans Fritz"'
Autor:
Hans Fritz, Petri T. Kovanen, Arnold von Eckardstein, Christian P. Sommerhoff, Miriam Lee, Frank Zettl
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 22:2086-2091
Objective— In human atherosclerotic lesions, degranulated mast cells are found in the vicinity of macrophage foam cells. Mast cell granules contain tryptase, a tetrameric serine protease requiring glycosaminoglycans for stabilization. No endogenous
Autor:
Andreas Holloschi, Hans Fritz, Shirley Gil-Parrado, Irmgard Assfalg-Machleidt, Eberhard Spiess, Ennes A. Auerswald, John C. Reed, Werner Machleidt, Oliver Popp, Amaury Ernesto Fernandez-Montalvan, Pablo Fuentes-Prior, Tobias Knoch, Guy S. Salvesen, Felix Bestvater, Katherine Welsh
Publikováno v:
Journal of Biological Chemistry. 277:27217-27226
Ubiquitous calpains (μ- and m-calpain) have been repeatedly implicated in apoptosis, but the underlying mechanism(s) remain(s) to be elucidated. We examined ionomycin-induced cell death in LCLC 103H cells, derived from a human large cell lung carcin
Autor:
Maria A. Juliano, Hans Fritz, Isabel de Fátima Correia Batista, Claudio A. M. Sampaio, Misako U. Sampaio, Ennes A. Auerswald, Maria Luiza Vilela Oliva, Sonia A. de Andrade
Publikováno v:
Immunopharmacology. 45:145-149
Kunitz type Bauhinia ungulata factor Xa inhibitor (BuXI) was purified from B. ungulata seeds. BuXI inactivates factor Xa and human plasma kallikrein (HuPK) with K i values of 18.4 and 6.9 nM, respectively. However, Bauhinia variegata trypsin inhibito
Autor:
Hans Fritz, Josep Vendrell, David Reverter, Francesc Canals, Francesc X. Avilés, Jeanny Horstmann, Christian P. Sommerhoff
Publikováno v:
Journal of Biological Chemistry. 273:32927-32933
A novel metallocarboxypeptidase inhibitor was isolated from the medical leech Hirudo medicinalis. Amino acid sequence analysis provided a nearly complete primary structure. which was subsequently verified and completed by cDNA cloning using reverse t
Autor:
Matthias Moser, Reinhard Mentele, Hans Fritz, Christoph Eckerskorn, Ennes A. Auerswald, Edwin Fink
Publikováno v:
European Journal of Biochemistry. 253:212-220
We have reported earlier the isolation and amino acid composition of bdellin A from medical leech, and characterised it as an inhibitor of trypsin, plasmin and acrosin [Fritz, H., Gebhardt, M., Meister, R. & Fink, E. (1971) in Proceedings of the inte
Autor:
Christian P. Sommerhoff, Milton T. Stubbs, Gerd P. Piechottka, Gabriele Matschiner, Hans Fritz, Robert Morenweiser, Wolfram Bode, Jörg Stürzebecher, Ennes A. Auerswald, Robert Huber, Margit Bauer
Publikováno v:
Journal of Biological Chemistry. 272:19931-19937
The x-ray crystal structure of recombinant leech-derived tryptase inhibitor (rLDTI) has been solved to a resolution of 1.9 A in complex with porcine trypsin. The nonclassical Kazal-type inhibitor exhibits the same overall architecture as that observe
Autor:
Markus G. Grütter, Stefania Di Marco, Jutta Heim, Hans Fritz, John P. Priestle, Christian P. Sommerhoff, Peer R. E. Mittl, Gabriele Pohlig, Gabriele Fendrich
Publikováno v:
Structure. 5(2):253-264
Background: Hirustasin belongs to a class of serine protease inhibitors characterized by a well conserved pattern of cysteine residues. Unlike the closely related inhibitors, antistasin/ghilanten and guamerin, which are selective for coagulation fact
Autor:
Aparecida S. Tanaka, Norlene R. Bueno, Misako U. Sampaio, Claudio A. M. Sampaio, Hans Fritz, Ennes A. Auerswald, Isabel de Fátima Correia Batista, Maria Luiza Vilela Oliva
Publikováno v:
Immunopharmacology. 32:62-66
The action of two Bowman-Birk and several plant Kunitz-type inhibitors were studied on trypsin, chymotrypsin, plasma kallikrein and factor XII. The primary structure of some of them was completely defined. The results showed that the Bowman-Birk type
Publikováno v:
Biochemical and Biophysical Research Communications. 214:389-395
A recombinant phage antibody system has been used to display functionally active chicken cystatin, a small protein-type inhibitor of papain-like cysteine proteinases. A synthetic gene, AEF-[S1M, M29I, M89L] chicken cystatin, was ligated into phagemid
Publikováno v:
Europe PubMed Central
The pharmacokinetics and the anticoagulant effects of hirudin were investigated in 12 healthy volunteers after single subcutaneous or intravenous bolus administrations. Hirudin concentrations in citrated plasma and urine were determined with a radioi