Zobrazeno 1 - 10
of 9 413
pro vyhledávání: '"Gordon, A"'
Autor:
Zhen Guo, Carla Valenzuela Ripoll, Antonino Picataggi, David R. Rawnsley, Mualla Ozcan, Julio A. Chirinos, Ezhilarasi Chendamarai, Amanda Girardi, Terrence Riehl, Hosannah Evie, Ahmed Diab, Attila Kovacs, Krzysztof Hyrc, Xiucui Ma, Aarti Asnani, Swapnil V. Shewale, Marielle Scherrer-Crosbie, Lauren Ashley Cowart, John S. Parks, Lei Zhao, David Gordon, Francisco Ramirez-Valle, Kenneth B. Margulies, Thomas P. Cappola, Ankit A. Desai, Lauren N. Pederson, Carmen Bergom, Nathan O. Stitziel, Michael P. Rettig, John F. DiPersio, Stefan Hajny, Christina Christoffersen, Abhinav Diwan, Ali Javaheri
Publikováno v:
JACC Basic Transl Sci
Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, D R, Ozcan, M, Chirinos, J A, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, S V, Scherrer-Crosbie, M, Cowart, L A, Parks, J S, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, K B, Cappola, T P, Desai, A A, Pedersen, L N, Bergom, C, Stitziel, N O, Rettig, M P, DiPersio, J F, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, ' Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury ', JACC: Basic to Translational Science, vol. 8, no. 3, pp. 340-355 . https://doi.org/10.1016/j.jacbts.2022.09.010
Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, D R, Ozcan, M, Chirinos, J A, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, S V, Scherrer-Crosbie, M, Cowart, L A, Parks, J S, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, K B, Cappola, T P, Desai, A A, Pedersen, L N, Bergom, C, Stitziel, N O, Rettig, M P, DiPersio, J F, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, ' Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury ', JACC: Basic to Translational Science, vol. 8, no. 3, pp. 340-355 . https://doi.org/10.1016/j.jacbts.2022.09.010
ObjectivesDetermine the role of apolipoprotein M (ApoM) in anthracycline (Dox) cardiotoxicity.BackgroundApoM binds the cardioprotective sphingolipid sphingosine-1-phosphate (S1P). Circulating ApoM is inversely associated with mortality in human heart
Publikováno v:
Academy of Management Perspectives. 36:744-767
Many countries face cycles of repeated violence. Attacks on health workers and facilities exact a toll on civilian access to care and, in aggregate, population health status. A variety of humanitar...
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 3, p e1004811 (2016)
PLoS Computational Biology
PLoS Computational Biology
Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step in the diaminopimelate pathway of bacteria, yielding amino acids required for cell wall and protein biosyntheses. The essentiality of the enzyme to bacteria, coupled with its abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8a23a2a0a6000afb8184439de56acd
Autor:
David Longmire, Haley Woods, Phillip B Rawlins, Jessie Hao-Ru Hsu, Daniel H O' Donovan, Alexandra Borodovsky, Peng Wang, Sharan K Bagal, Shaun M Fillery, Peter Barton, Clare Gregson, Beth Williamson, Samuel C Nash, Andrew Pike, Jon A Read, Kurt Gordon Pike, Andrew Bloecher, Erin Code, Minhui Shen, Sameer Kawatkar, Youfeng Nai, Jia Tang, Chengzhi Li, James C. Robinson
Publikováno v:
Journal of Medicinal Chemistry. 64:17146-17183
Aberrant activity of the histone methyltransferase polycomb repressive complex 2 (PRC2) has been linked to several cancers, with small-molecule inhibitors of the catalytic subunit of the PRC2 enhancer of zeste homologue 2 (EZH2) being recently approv
Autor:
Konstantina Psachoulia, Eva-Lotte Lindstedt, Carl Whatling, Gordon Law, Iain MacPhee, Hans Ericsson, Hiddo J.L. Heerspink, Kathleen Connolly, Jane Knöchel
Publikováno v:
Kidney International Reports
Kidney International Reports, 6(11), 2803-2810. ELSEVIER SCIENCE INC
Kidney International Reports, 6(11), 2803-2810. ELSEVIER SCIENCE INC
Introduction Patients with chronic kidney disease (CKD) remain at risk for kidney and cardiovascular events resulting from residual albuminuria, despite available treatments. Leukotrienes are proinflammatory and vasoconstrictive lipid mediators impli
Autor:
Holly J. Clarke, William H. Yang, Timothy T. Lu, Joshua Galanter, Petra Staubach, Tonny Tanus, Tracy Burgess, Gordon Sussman, Jeremy J. Lim, Leslie W. Chinn, Remi Gagnon, D. James Haddon, Tom Chu, Marcus Maurer, Anastasia Teterina, Martin Metz
Publikováno v:
Nature Medicine. 27:1961-1969
Bruton’s tyrosine kinase (BTK) is crucial for FceRI-mediated mast cell activation and essential for autoantibody production by B cells in chronic spontaneous urticaria (CSU). Fenebrutinib, an orally administered, potent, highly selective, reversibl
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1662-1669
Glutamate differentially affects the levels extracellular signal-regulated kinase (ERK)1/2 and ERK3 and the protective effect of B355252, an aryl thiophene compound, 4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonam
Autor:
Peter D. Kwong, Misook Choe, Bonnie M. Slike, M. Gordon Joyce, Samantha M. Townsley, Elizabeth J. Martinez, Tongqing Zhou, Lindsay Wieczorek, Morgane Rolland, Kayvon Modjarrad, Dominic Paquin-Proulx, Vincent Dussupt, Weam I. Zaky, Nelson L. Michael, Magdalena Rutkowska, Isabella Swafford, Benjamin J. Doranz, Shelly J. Krebs, Theodora Hatziioannou, Gregory D. Gromowski, Ningbo Jian, Caroline E. Peterson, Phyllis A. Rees, Clayton Smith, Michelle Zemil, Paul D. Bieniasz, Kerri G. Lal, Victoria R. Polonis, I-Ting Teng, Gina Donofrio, William W. Reiley, Wei-Hung Chen, Christopher N. Selverian, Rajeshwer S. Sankhala, Jeffrey R. Currier, Aslaa Ahmed, Letzibeth Mendez-Rivera, Ursula Tran, Nathaniel D. Jackson, Agnes Hajduczki, Paul V. Thomas, Sarah R. Tritsch, William C. Chang, Fabian Schmidt, Edgar Davidson, Christopher N. Mores
Publikováno v:
Nature Immunology
Prevention of viral escape and increased coverage against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal antibodies (mAbs) targeting multiple sites of vulnerability on the coronavirus s
Publikováno v:
Current Obstetrics and Gynecology Reports. 10:61-70
Anti-Mullerian hormone (AMH) is secreted by ovarian granulosa cells and has become a surrogate marker for ovarian reserve. We review anticipated AMH levels throughout the reproductive lifespan and how AMH levels can be used in assisted reproductive t
Autor:
Yen-Hua Huang, Brett M. Collins, Huawu Yin, Conan K. Wang, David J. Craik, Yanfeng Gao, Gordon J. King, Xiuman Zhou
Publikováno v:
Journal of the American Chemical Society. 143:18536-18547
Peptides have potential to be developed into immune checkpoint inhibitors, but the target interfaces are difficult to inhibit. Here, we explored an approach to mimic the binding surface of PD-1 to design inhibitors. Mimicking native PD-1 resulted in