Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gautam Sikka"'
Autor:
Vanessa C. Pau, Gautam Sikka, Benjamin D. Levine, Jochen Steppan, Lakshmi Santhanam, Dan E. Berkowitz, Young Jun Oh, Daniel Nyhan, Valeriani R. Bead
Publikováno v:
Amino Acids. 49:695-704
Aging is associated with increased cardiomyocyte loss, left-ventricular hypertrophy, and the accumulation of extracellular matrix, which results in declining cardiac function. The role of the matrix crosslinking enzyme, tissue transglutaminase (TG2),
Autor:
Gautam Sikka, Sineád M. Nyhan, Artin A. Shoukas, Ayushi Ahuja, Anthony R. White, Jorge A. Uribe, Jochen Steppan, Dan E. Berkowitz
Publikováno v:
Anesthesia & Analgesia. 115:1290-1295
BACKGROUND Vasopressin is frequently used to treat catecholamine-resistant vasodilatory shock. It enhances the vasoconstrictor effects of catecholamines at concentrations of vasopressin that have none or only minimal intrinsic pressor effects. Howeve
Autor:
Alexey M. Belkin, Eric C. Tuday, Daniel Nyhan, Jae Hyung Kim, Anne M. Macgregor, David Yin, Jessilyn Dunn, Young Jun Oh, Sarah R. Gutbrod, Nicholas A. Flavahan, Marc K. Halushka, Alanah Webb, Lakshmi Santhanam, Artin A. Shoukas, Gautam Sikka, Dan E. Berkowitz, Phillip Dowzicky, Maggie Kuo
Publikováno v:
Circulation Research. 107:117-125
Rationale : Although an age-related decrease in NO bioavailability contributes to vascular stiffness, the underlying molecular mechanisms remain incompletely understood. We hypothesize that NO constrains the activity of the matrix crosslinking enzyme
Autor:
Kevin G. Soucy, Gautam Sikka, Hunter C. Champion, Gaurav Gupta, Artin A. Shoukas, Dan E. Berkowitz, David W. Christianson, Hyun Kyo Lim, Nicholas J. Alp, Sungwoo Ryoo, David Huso, Eric C. Tuday, Gary Gerstenblith, Alexandre M. Benjo, Lakshmi Santhanam, Daniel Nyhan, Andre Camara, Jayson S. Sohi, Monica Ilies, Hyun Kyung Lim, Ezra Baraban
Publikováno v:
Circulation Research. 102:923-932
Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular endothelial arginase activity is increased in atherogenic-prone apolipoprotein
Publikováno v:
Circulation Research. 110
We first acknowledge the profound contribution that Edwards, Feletou, and Weston have made over many years to our understanding of the role of endothelial-derived hyperpolarizing factors in the regulation of vascular function in health and disease. I