Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dolph L. Hatfield"'
Autor:
Jeyoung Bang, Dolph L. Hatfield, Lu Qiao, Tack-Jin Yoo, Yoomin Kim, Byeong Jae Lee, Lark Kyun Kim, Jisu Jung, Bradley A. Carlson, Jin-Hong Kim, Donghyun Kang, Jiwoon Na, Dongin Kwon
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11646, p 11646 (2021)
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11646, p 11646 (2021)
The primary function of selenophosphate synthetase (SEPHS) is to catalyze the synthesis of selenophosphate that serves as a selenium donor during selenocysteine synthesis. In eukaryotes, there are two isoforms of SEPHS (SEPHS1 and SEPHS2). Between th
Autor:
Yassin Mahdi, Ulrich Schweizer, Donna M. Driscoll, Bradley A. Carlson, Angela C. Miniard, Eva K. Wirth, Sandra Seeher, Dolph L. Hatfield
Publikováno v:
Biochemical Journal. 462:67-75
Secisbp2 [SECIS (selenocysteine insertion sequence)-binding protein 2] binds to SECIS elements located in the 3′-UTR region of eukaryotic selenoprotein mRNAs. It facilitates the incorporation of the rare amino acid selenocysteine in response to UGA
Autor:
Anton A. Turanov, Marina V. Kasaikina, Vadim N. Gladyshev, Byung Cheon Lee, Lydia Finney, Dmitri E. Fomenko, Alexei Lobanov, Javier Seravalli, Richard A. Miller, Thomas J. Park, Stefan Vogt, Dolph L. Hatfield, Mikalai Yu. Malinouski
Publikováno v:
Journal of Biological Chemistry. 286:17005-17014
Naked mole rat (MR) Heterocephalus glaber is a rodent model of delayed aging because of its unusually long life span (28 years). It is also not known to develop cancer. In the current work, tissue imaging by x-ray fluorescence microscopy and direct a
Autor:
Bradley A. Carlson, Dolph L. Hatfield, Min-Hyuk Yoo, Xue Ming Xu, Renu Nandakumar, Robert A. Everley, Anton A. Turanov, Irina Sorokina, Vadim N. Gladyshev, Steven P. Gygi
Publikováno v:
Proceedings of the National Academy of Sciences. 107:21430-21434
Cysteine (Cys) is inserted into proteins in response to UGC and UGU codons. Herein, we show that supplementation of mammalian cells with thiophosphate led to targeted insertion of Cys at the UGA codon of thioredoxin reductase 1 (TR1). This Cys was sy
Autor:
Dolph L. Hatfield, Min-Hyuk Yoo, Rajeev K. Shrimali, Vadim N. Gladyshev, Jin Mo Park, Robert Irons, Bradley A. Carlson
Publikováno v:
Proceedings of the Nutrition Society. 69:300-310
Selenium (Se) has been known for many years to have played a role in boosting the immune function, but the manner in which this element acts at the molecular level in host defence and inflammatory diseases is poorly understood. To elucidate the role
Autor:
Georg W. Bornkamm, Ulrich Schweizer, Christian Wozny, Vincenzo Coppola, Josef Köhrle, Jochen Winterer, Eva K. Wirth, Dolph L. Hatfield, Marcus Conrad, Stephan Roth, Lino Tessarollo, Bradley A. Carlson, Lutz Schomburg, Dietmar Schmitz
Publikováno v:
The FASEB Journal. 24:844-852
Cerebral selenium (Se) deficiency is associated with neurological phenotypes including seizures and ataxia. We wanted to define whether neurons require selenoprotein expression and which selenoproteins are most important, and explore the possible pat
Autor:
Bradley A. Carlson, Vadim N. Gladyshev, Markus C. Wahl, Dolph L. Hatfield, Heiko Mix, Xue-Ming Xu, Oleg M. Ganichkin
Publikováno v:
Journal of Biological Chemistry
In eukaryotes and Archaea, selenocysteine synthase (SecS) converts O-phospho-L-seryl-tRNA [Ser]Sec into selenocysteyl-tRNA [Ser]Sec using selenophosphate as the selenium donor compound. The molecular mechanisms underlying SecS activity are presently
Autor:
Patricia A. Sheridan, Dolph L. Hatfield, Christine M. Perella, Nianxin Zhong, Bradley A. Carlson, Melinda A. Beck
Publikováno v:
The Journal of Nutrition. 137:1466-1471
Previous work from our laboratory demonstrated that host selenium (Se) deficiency results in greater lung pathology and altered immune function in mice infected with influenza virus. Because selenoproteins play a key role in determining the oxidant s
Autor:
Jang Hoe Huh, Ji-Woon Na, Bradley A. Carlson, Vadim N. Gladyshev, Ryuta Tobe, Dolph L. Hatfield, Byeong Jae Lee, Jeyoung Bang, Mihyun Jang, Petra A. Tsuji, Myoungsup Shim
Publikováno v:
Biochemical and biophysical research communications. 456(4)
The 15-kDa selenoprotein (Sep15) has been implicated in etiology of some types of cancer. Herein, inducible RNAi cell lines were established and cell morphology and motility were analyzed. The majority of Sep15-deficient cells (>95%) formed membrane
Autor:
Qi An Sun, You Zhou, Dolph L. Hatfield, Mohamed E. Moustafa, Dan Su, Richard Oko, Sergey V. Novoselov, Vadim N. Gladyshev
Publikováno v:
Journal of Biological Chemistry. 280:26491-26498
Thioredoxin reductases (TRs) are important redox regulatory enzymes, which control the redox state of thioredoxins. Mammals have cytosolic and mitochondrial TRs, which contain an essential selenocysteine residue and reduce cytosolic and mitochondrial