Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Daniel D. De Carvalho"'
Autor:
Karan J. Abraham, Miling Wang, Jack Greenblatt, Lauren A. Ostrowski, Aparna Gorthi, Parasvi S. Patel, Daniel D. De Carvalho, Razq Hakem, Michael Ohh, Roxanne Oshidari, Alexander J.R. Bishop, Violena Pietrobon, Anas Samman, Arash Algouneh, Dorothy Yanling Zhao, Stephen Lee, Michael Bokros, Janet N.Y. Chan, V Talya Yerlici, Rajat Singhania, Brendan C. Dickson, Yupeng Liu, Elva Vidya, Negin Khosraviani, Karim Mekhail
Publikováno v:
Nature
Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol I and Pol III) are the
Autor:
Michael J. Johnston, Parinaz Mehdipour, Douglas J. Mahoney, Katrina Ellestad, Christopher J Gafuik, Jennifer A. Chan, Ana Nikolic, Daniel D. De Carvalho, Nicoletta Ninkovic, Steven J.M. Jones, Xueqing Lun, Anna Bobyn, Peter B. Dirks, Francesca Maule, Yaoqing Shen, Darren J. Derksen, N. Daniel Berger, Donna L. Senger, Duncan K. Brownsey, Marco Gallo, Franz J. Zemp, Sajid A. Marhon
SUMMARYSelf-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe58287f85fb3fd3054c88f6e24aee0
https://doi.org/10.1101/2021.02.23.432465
https://doi.org/10.1101/2021.02.23.432465
Publikováno v:
Nature Reviews Cancer. 19:151-161
DNA methylation inhibitors have become the mainstay for treatment of certain haematological malignancies. In addition to their abilities to reactivate genes, including tumour suppressors, that have acquired DNA methylation during carcinogenesis, they
Autor:
Minkui Luo, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Tiago Medina, H. Ümit Kaniskan, Matthieu Schapira, David Smil, Paul L. Richardson, Jian Jin, David McLeod, Colby Zaph, Andrew M. Lewis, Jennifer A. Ward, Daniel D. De Carvalho, Fengling Li, Sebastian Scheer, Jeffrey P. Northrop, Peter Brown, Kilian Huber, Yudao Shen, Suzanne Ackloo, Carlos Zepeda-Velázquez, Jing Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs
Autor:
Johann Hitzler, Laura García-Prat, Sabrina A. Smith, Gabriela Krivdova, Daniel D. De Carvalho, Olga I. Gan, Maria Azkanaz, Leonardo Salmena, Maian Roifman, Elvin Wagenblast, Karen Chong, David Chitayat, John E. Dick, Alex Murison, Eric R. Lechman, Martino Gabra, Jessica McLeod, Sarah K Cutting, Jean C.Y. Wang, Sajid A. Marhon, Joana Araújo, Patrick Shannon, Michelle Chan-Seng-Yue
Children with Down syndrome have a 150-fold increased risk of developing myeloid leukemia, but the mechanism of predisposition is unclear. As Down syndrome leukemogenesis initiates during fetal development, we characterized the cellular context of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5102fa236e1ee48daea0d4391094e5d2
https://doi.org/10.1101/2020.11.29.402800
https://doi.org/10.1101/2020.11.29.402800
Autor:
Giselle M. Boukhaled, David G. Brooks, Felipe Campos de Almeida, David Allard, Sajid A. Marhon, David Roulois, Joaquín Arribas, Ilias Ettayebi, Tiago Medina, Parinaz Mehdipour, Gustavo P. Amarante-Mendes, Sandra Pommey, John Stagg, Daniel D. De Carvalho, Helen Loo Yau, Isabela M. Gonzaga, Shu Yi Shen, Ankur Chakravarthy, Christian Klein, Beatriz Morancho, Raymond Chen, Emma Bell, Charles A. Ishak, Rajat Singhania
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
Molecular Cell, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
Universidade de São Paulo (USP)
instacron:USP
Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
Molecular Cell, 2021, 81 (7), pp.1469-1483.e8. ⟨10.1016/j.molcel.2021.01.038⟩
International audience; We demonstrate that DNA hypomethylating agent (HMA) treatment can directly modulate the anti-tumor response and effector function of CD8(+) T cells. In vivo HMA treatment promotes CD8(+) T cell tumor infiltration and suppresse
Autor:
Dalia Barsyte-Lovejoy, Bradly G. Wouters, Jian Jin, Jennifer Haynes, Antonija Kreso, Aaron Pollett, Anqi Ma, Catherine A. O’Brien, Cherry Leung, Evelyne Lima-Fernandes, Daniel D. De Carvalho, Genna M. Luciani, Yadong Wang, Shili Duan, Mathieu Lupien, Constanze Zeller, Tiago Medina, Alex Murison, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
In embryonic stem cells, promoters of key lineage-specific differentiation genes are found in a bivalent state, having both activating H3K4me3 and repressive H3K27me3 histone marks, making them poised for transcription upon loss of H3K27me3. Whether
Autor:
Mathieu Lupien, Yulia Jitkova, Michael Mullokandov, Helen Loo Yau, Rima Al-awar, James R. Hawley, Rose Hurren, Troy Ketela, S. Kim, Veronique Voisin, Neil MacLean, Daniel D. De Carvalho, Mark D. Minden, Geethu E. Thomas, Val A. Fajardo, Ahmed Aman, Zhenyue Hao, Zaza Khuchua, G. Wei Xu, Gary D. Bader, Richard P. Bazinet, Juan J. Aristizabal Henao, Mingjing Xu, Paul J. LeBlanc, Ayesh K. Seneviratne, Steven M. Claypool, Steven M. Chan, Xiaoming Wang, Atan Gross, Aaron D. Schimmer, Ken D. Stark, David Sharon, Raphaël Chouinard-Watkins, Danny V. Jeyaraju, Caitlin Schafer, Marcela Gronda
Summary Tafazzin (TAZ) is a mitochondrial transacylase that remodels the mitochondrial cardiolipin into its mature form. Through a CRISPR screen, we identified TAZ as necessary for the growth and viability of acute myeloid leukemia (AML) cells. Genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b74e60e809d7c98db8697836fef410
https://europepmc.org/articles/PMC7137093/
https://europepmc.org/articles/PMC7137093/
Autor:
Benjamin Ellezam, Paul Guilhamon, Peter W. Lewis, Nicolas De Jay, Nada Jabado, Josie Ursini-Siegel, Sameer Agnihotri, Mathieu Lupien, Peter B. Dirks, Paul Lasko, Ashot S. Harutyunyan, Stephen C. Mack, Damien Faury, Robert F. Koncar, Carol C.L. Chen, Paolo Salomoni, Dylan M. Marchione, Shriya Deshmukh, Daniel D. De Carvalho, Leonie G. Mikael, Alexander G. Weil, Claudia L. Kleinman, Melissa K. McConechy, Brian Krug, Kelsey C. Bertrand, Benjamin A. Garcia, Sima Khazaei, Cheryl H. Arrowsmith
Publikováno v:
Cancer Cell
Cancer cell 35(5), 782-797.e8 (2019). doi:10.1016/j.ccell.2019.04.004
Cancer cell 35(5), 782-797.e8 (2019). doi:10.1016/j.ccell.2019.04.004
High-grade gliomas (HGG) defined by histone 3 K27M driver mutations exhibit global loss of H3K27 trimethylation and reciprocal gain of H3K27 acetylation, respectively shaping repressive and active chromatin landscapes. We generated tumor-derived isog
Autor:
Minkui Luo, Daniel D. De Carvalho, Masoud Vedadi, Suzanne Ackloo, Andrew M. Lewis, Jian Jin, Matthieu Schapira, Tiago Medina, Colby Zaph, H. Ümit Kaniskan, Jeffrey P. Northrop, Yudao Shen, Jing Liu, Jennifer A. Ward, Dalia Barsyte-Lovejoy, Kilian Huber, David Smil, Sebastian Scheer, Cheryl H. Arrowsmith, Fengling Li, Peter Brown, Paul L. Richardson
SUMMARYProtein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96df785a4e892e1537e723a9d29daae
https://doi.org/10.1101/260638
https://doi.org/10.1101/260638