Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Cubitt, A"'
Autor:
Lisa Pickering, Richard Stone, Ian Chau, James I. MacRae, Karla Lingard, Susana Banerjee, Barry Ward, Jessica Bazin, William Gordon, Naureen Starling, Katalin A. Wilkinson, Mary O'Brien, Anna Robinson, Joanne Droney, Sacheen Kumar, Emma Nicholson, Martin Pule, Isla Leslie, Andreas M. Schmitt, Ambrosius P. Snijders, Karolina Rzeniewicz, Emma Nye, Benjamin Shum, Mary Mangwende, Scott Shepherd, Nalinie Joharatnam-Hogan, Robyn L. Shea, Michael Howell, Anthony J. Swerdlow, Shaman Jhanji, Simon Caidan, Eleanor Carlyle, Laura Amanda Boos, Annika Fendler, Kevin W. Ng, Kate Tatham, Leila Mekkaoui, Tim Slattery, Margaret Crawford, Firza Gronthoud, Philip Hobson, Camila Gomes, Robert J. Wilkinson, Jerome Nicod, Charles Swanton, Mike Gavrielides, Kim Edmonds, Robin L. Jones, Fiona Byrne, Laura Cubitt, Alison Reid, Lucy Holt, Ana Agua-Doce, Ruth Harvey, Sarah Sarker, Spyridon Gennatas, Camille L. Gerard, Andrew Furness, Hamid Ahmod, Liam Welsh, Nicholas van As, Olivia Curtis, Nadia Yousaf, Mary Wu, Nicholas C. Turner, Christina Messiou, David Cunningham, Zayd Tippu, Georgina H. Cornish, Sonia Gandhi, Helen R. Flynn, Harshil Patel, Yasir Khan, James Larkin, Lewis Au, George Kassiotis, Samra Turajlic, Maddalena Cerrone, Clemency Stephenson, Steve Gamblin, Kate Young, Wenyi Xie, Shreerang Bhide, Robert L. Goldstone, Alicia Okines, Kevin J. Harrington, Lyra Del Rosario
Publikováno v:
Nature Cancer
Research Square
article-version (status) pre
article-version (number) 1
Research Square
article-version (status) pre
article-version (number) 1
Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. Of 357 patients with cancer, 118 were SARS-CoV-2 positive, 94 were s
Autor:
Katherine Harcourt, Michael R. West, Thomas T. MacDonald, Lurdes Rodrigues-Duarte, Anna Vossenkämper, Keith P. Ray, Ray Chai, Luana Maggiore, Marion F. Cubitt, Timothy M. Carlton, Simon Clare, J. Scott Crowe, Kevin J. Roberts
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Anti-TNFα and anti-IL-23 antibodies are highly effective therapies for Crohn’s disease or ulcerative colitis in a proportion of patients. V56B2 is a novel bispecific domain antibody in which a llama-derived IL-23p19-specific domain antibody, human
Autor:
K. Michael Pollard, Donald S. Grant, Kayla Shore, Michael B. A. Oldstone, Luis M. Branco, Robert F. Garry, Augustine Goba, Jessica M Mayeux, Mambu Momoh, John Demby Sandi, Mohamed Yilah, Lansana Kanneh, John S. Schieffelin, Matthew L. Boisen, Saori Sakabe, Foday Al-Hassan, Stephanie LaVergne, Juan Carlos de la Torre, Iris Bica, Michael Gbakie, Ashley A. Smira, Brian M Sullivan, Beatrice Cubitt
Publikováno v:
J Infect Dis
BackgroundEbola virus (EBOV) disease has killed thousands of West and Central Africans over the past several decades. Many who survive the acute disease later experience post-Ebola syndrome, a constellation of symptoms whose causative pathogenesis is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d46cba913a6ea143e4d5d8152d8c26a
https://europepmc.org/articles/PMC7529037/
https://europepmc.org/articles/PMC7529037/
Autor:
Mohammed Mahmood Hussain, Rebecca L. Cubitt, Matt Kanke, Yu-Han Hung, Rodica P. Bunaciu, Catherine Lisa Kurtz, Praveen Sethupathy, Liye Zhou, Xiaoling Li, Phillip J. White, Kasey C. Vickers
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology
Frontiers in Physiology
MicroRNAs (miRNAs) are known regulators of lipid homeostasis. We recently demonstrated that miR-29 controls the levels of circulating cholesterol and triglycerides, but the mechanisms remained unknown. In the present study, we demonstrated that syste
Autor:
Andrew S. Brohl, Damon R. Reed, Yonghong O. Zhang, Darcy Welch, Jae K. Lee, Diana Yu, Jamie K. Teer, Margaret R. Wallace, Elliot Kahen, Yunyun Chen, Sean J. Yoder, Christopher L. Cubitt
Publikováno v:
Oncotarget
Malignant peripheral nerve sheath tumor (MPNST) is a type of soft-tissue sarcoma strongly associated with dysfunction in neurofibromin; an inhibitor of the RAS pathway. We performed high-throughput screening of an array of FDA approved and promising
Autor:
Jan R Robinson, Gary A Whale, Michael R. West, Jonathan I Humphreys, J. Scott Crowe, Timothy M. Carlton, Kevin J. Roberts, John C Wahlich, Marion F. Cubitt, Luana Maggiore, Mary C Donnelly, Keith P. Ray
Publikováno v:
Drug development and industrial pharmacy. 45(3)
V565 is a novel oral anti-tumor necrosis factor (TNF)-α domain antibody being developed for topical treatment of inflammatory bowel disease (IBD) patients. Protein engineering rendered the molecule resistant to intestinal proteases. Here we investig
Autor:
Katrina Mitchel, Devesh Naidoo, Elizabeth Theusch, Andréa C. Dosé, Marisa W. Medina, Kristen Stevens, Celia Cubitt
Publikováno v:
Circulation: Cardiovascular Genetics. 9:223-230
Background— Numerous genetic contributors to cardiovascular disease risk have been identified through genome-wide association studies; however, identifying the molecular mechanism underlying these associations is not straightforward. The Justificat
Autor:
Jennifer A. Foltz, Julia A. Wagner, Lynne Marsala, Melissa M. Berrien-Elliott, Todd A. Fehniger, Nermina Saucier, Timothy Schappe, Ryan P. Sullivan, Pamela Wong, Celia C. Cubitt, Molly P. Keppel, Natalia Jaeger, Megan A. Cooper, Carly Neal, Madeline Lee, Stephanie E. Schneider, Cassie Keppel, Nancy D. Marin
Publikováno v:
Cell Reports
Cell Reports, Vol 31, Iss 9, Pp-(2020)
Cell Reports, Vol 31, Iss 9, Pp-(2020)
Summary Natural killer (NK) cells are cytotoxic innate lymphoid cells (ILCs) that mediate antiviral and antitumor responses and require the transcriptional regulator Eomesodermin (Eomes) for early development. However, the role of Eomes and its molec
Autor:
Marion F. Cubitt, Michael R. West, Simon Clare, Luana Maggiore, Thomas T. MacDonald, Keith P. Ray, Timothy M. Carlton, Kevin J. Roberts, Katherine Harcourt, J. Scott Crowe, Anna Vossenkämper, Jill Reckless
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
TNFα is an important cytokine in inflammatory bowel disease. V565 is a novel anti-TNFα domain antibody developed for oral administration in IBD patients, derived from a llama domain antibody and engineered to enhance intestinal protease resistance.
Autor:
Claudio Anasetti, Anandharaman Veerapathran, Brian C. Betts, Nicholas J. Lawrence, Joseph Pidala, Hua Yang, Harshani R. Lawrence, Steven Gunawan, Pedro Horna, Said M. Sebti, Christopher L. Cubitt, Kelly Walton
Publikováno v:
Science Translational Medicine. 9
Graft-versus-host disease (GVHD) is a leading cause of nonrelapse mortality after allogeneic hematopoietic cell transplantation. T cell costimulation by CD28 contributes to GVHD, but prevention is incomplete when targeting CD28, downstream mammalian