Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Cheryl H. Arrowsmith"'
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Autor:
Rachel Harding, M.K. Mann, Ahmed Aman, Carlos Zepeda-Velázquez, Brian J. Wilson, Taira Kiyota, Cheryl H. Arrowsmith, Peter Loppnau, Rima Al-awar, Matthieu Schapira, Héctor González-Álvarez, Yanjun Li, Aiping Dong
Publikováno v:
Journal of Medicinal Chemistry. 64:15017-15036
USP5 is a deubiquitinase that has been implicated in a range of diseases, including cancer, but no USP5-targeting chemical probe has been reported to date. Here, we present the progression of a chemical series that occupies the C-terminal ubiquitin-b
Publikováno v:
Nature Structural & Molecular Biology. 26:863-869
Chromatin regulatory proteins are increasingly recognized as potential new drug targets. Many of these proteins harbor one or more so called ‘reader domains’ that recognize covalent modifications of lysine and arginine residues, typically on hist
Autor:
Rima Al-awar, Taira Kiyota, Matthieu Schapira, M.K. Mann, Carlos Zepeda-Velázquez, Rachel Harding, Ahmed Aman, Cheryl H. Arrowsmith, H.G. Alvarez, A. Dong
USP5 is a deubiquitinase that has been implicated in a range of diseases, including cancer, but no USP5-targeting chemical probe has been reported to date. Here, we present the progression of a chemical series that occupies the C-terminal ubiquitin-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::384a9b2f5329ddc45417c141a66ae99d
https://doi.org/10.1101/2021.05.17.444542
https://doi.org/10.1101/2021.05.17.444542
Autor:
N. Berner, Magda Szewczyk, B. Kuester, J. Weckesser, Martin Eilers, Andreas Kraemer, Christoph A. Sotriffer, Volker Doetsch, Bikash Adhikari, Frank Loehr, Stephanie Heinzlmeir, Dalia Barsyte-Lovejoy, A. Doelle, Mathias Diebold, Elmar Wolf, J. Gerbel, Lena M. Berger, Stefan Knapp, Cheryl H. Arrowsmith
Histone H3K4 methylation serves as post-translational hallmark of actively transcribed genes and is introduced by histone methyltransferases (HMT) and its regulatory scaffolding proteins. One of these is the WD-repeat containing protein 5 (WDR5) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bb60d0d7a9cb8061918d0989716e03b
https://doi.org/10.1101/2021.04.12.439490
https://doi.org/10.1101/2021.04.12.439490
Autor:
Jinrong Min, Matthew R. Marunde, Dmitri Kireev, Jack Greenblatt, Ferreira de Freitas R, Tigran M. Abramyan, Cheryl H. Arrowsmith, Peter Brown, Magda Szewczyk, Irene Chau, A. Dong, Kazemzadeh S, Dalia Barsyte-Lovejoy, Ronan P Hanley, Mengqi Zhou, Y. Liu, Michael-Christopher Keogh, Lindsey I. James, Edyta Marcon, Matthieu Schapira, David Dilworth, Ming Lei, Popova Ik, Albina Bolotokova, Marcus A. Cheek, Masoud Vedadi, Elisa Gibson, Suzanne Ackloo, Su Qin, Matthew J. Meiners, Nathan W. Hall, Abdellah Allali-Hassani, Naimee Mehta, Fengling Li
NSD2 is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36me2), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methyltransferase domain, NSD2 harbors two PWWP and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e4c6ef23b32f1b09d83b9d0588c0ec9
https://doi.org/10.1101/2021.03.05.433782
https://doi.org/10.1101/2021.03.05.433782
Autor:
Zhen Wang, Jiemin Wong, Jiwen Li, Peter Brown, Lan Fang, Cheryl H. Arrowsmith, Yuanyong Huang, Li Kang, Menghan Li, Huifang Zhang
Publikováno v:
Oncogene. 38:5250-5264
As a transcription factor critical for embryonic and adult stem cell self-renewal and function, SOX2 gene amplification has been recognized as a driving factor for various cancers including esophageal cancer. SOX2 overexpression occurs more broadly i
Autor:
Minkui Luo, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Tiago Medina, H. Ümit Kaniskan, Matthieu Schapira, David Smil, Paul L. Richardson, Jian Jin, David McLeod, Colby Zaph, Andrew M. Lewis, Jennifer A. Ward, Daniel D. De Carvalho, Fengling Li, Sebastian Scheer, Jeffrey P. Northrop, Peter Brown, Kilian Huber, Yudao Shen, Suzanne Ackloo, Carlos Zepeda-Velázquez, Jing Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes with therapeutic relevance. Here we present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine PMTs
Autor:
Panagis Filippakopoulos, Dalia Barsyte-Lovejoy, Edyta Marcon, Elizabeth Henderson, Cheryl H. Arrowsmith, Jack Greenblatt, Ashley Hutchinson, Levon Halabelian, Alma Seitova, Danton Ivanochko, Pavel Savitsky, Evelyne Lima-Fernandes, Harshika Jain, Shili Duan
Publikováno v:
Nucleic Acids Research
Aberrant isoform expression of chromatin-associated proteins can induce epigenetic programs related to disease. The MDS1 and EVI1 complex locus (MECOM) encodes PRDM3, a protein with an N-terminal PR-SET domain, as well as a shorter isoform, EVI1, lac
Autor:
Cheryl H. Arrowsmith, Andrew T. Quaile, Alexander Lemak, Alexei Savchenko, Dustin J. Little, Scott Houliston, Brian K. Coombes, Tatiana Skarina, Dylan Valleau, Rosa Di Leo, Dominika Borek
Publikováno v:
Proceedings of the National Academy of Sciences. 115:10004-10009
The pathogenic strategy of Escherichia coli and many other gram-negative pathogens relies on the translocation of a specific set of proteins, called effectors, into the eukaryotic host cell during infection. These effectors act in concert to modulate