Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Rajesh Kumar Dutta, Seh-Hoon Oh, Wen-Hsuan Yang, Jen-Tsan Ashley Chi, Kuo Du, Anna Mae Diehl, Tianai Sun
Publikováno v:
Liver Int
Background & aims The outcome of liver injury is dictated by factors that control the accumulation of myofibroblastic (activated) hepatic stellate cells (MF-HSCs) but therapies that specifically block this process have not been discovered. We evaluat
Autor:
C. Stephen Djedjos, Raul Aguilar Schall, Zachary Goodman, B. Mccolgan, G. Mani Subramanian, Anna Mae Diehl, Nezam H. Afdhal, Andrew J. Muir, Jaime Bosch, Vlad Ratziu, Zobair M. Younossi, Manal F. Abdelmalek, Arun J. Sanyal, Stephen H. Caldwell, Mitchell L. Shiffman, Catherine Jia, John G. McHutchison, Stephen A. Harrison, Robert P. Myers
Publikováno v:
Hepatology
Progression of nonalcoholic steatohepatitis (NASH) is incompletely characterized. We analyzed data on longitudinal changes in liver histology, hepatic venous pressure gradient (HVPG), and serum markers of fibrosis in 475 patients with NASH with bridg
Autor:
Wing-Kin Syn, Keyur Patel, Cynthia D. Guy, Anna Mae Diehl, Robert D. Streilein, Ricardo Henao, Oliver Glass, Hans J Gruss, Manal F. Abdelmalek, Cynthia A. Moylan, Russell P. Hall
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
The severity of hepatic fibrosis is the primary predictor of liver‐related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD‐associated fibrosis are limited. W
Background and AimsLiver fibrosis develops in the context of excessive oxidative stress, cell death and accumulation of myofibroblasts (MFs) derived from hepatic stellate cells (HSCs). Ferroptosis is a type of regulated cell death that can be caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef9c6e3dd3130b4a811e359e407a456
https://doi.org/10.1101/2019.12.23.886259
https://doi.org/10.1101/2019.12.23.886259
Autor:
Jeongeun Hyun, Anna Mae Diehl, Matthew B Friedersdorf, Youngmi Jung, Seh-Hoon Oh, Jack D. Keene, Richard T. Premont, Ji Eun Kim, Sihyung Wang
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 3, Pp 1215-1229 (2018)
Background/Aims: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in cirrhosis. Because many factors interact to regulate expansion and regression of MF-HSC populations, eff
Autor:
Bryan W. Brooks, Mitzi Nagarkatti, Samir Raychoudhury, Anna Mae Diehl, Sutapa Sarkar, Dwayne E. Porter, Geoff Scott, Diana Kimono, Muayad Albadrani, Saurabh Chatterjee, Yvon Jule, Dipro Bose, Ratanesh Seth, Ayan Mondal, Prakash S. Nagarkatti
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Nonalcoholic fatty liver disease (NAFLD) is an emerging global pandemic. Though significant progress has been made in unraveling the pathophysiology of the disease, the role of protein phosphatase 2A (PP2A) and its subsequent inhibition by environmen
Autor:
Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, Varun Chandrashekaran, Jacek Ziolenka, Diptadip Dattaroy, Firas Alhasson, James A. Carson, Ratanesh Seth, Saurabh Chatterjee
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 8-19 (2017)
Redox Biology
Redox Biology
Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown. The present study identifies high mobility
Autor:
Sihyung Wang, Jaewook Lee, Hee-Jae Cha, Ji Eun Kim, Youngmi Jung, Eun-Yi Moon, Chanbin Lee, Anna Mae Diehl, Jeongeun Hyun
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
SCIENTIFIC REPORTS(7)
Scientific Reports
SCIENTIFIC REPORTS(7)
Scientific Reports
The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that TB4 influences HSC activation through hedgehog (Hh) pathway. HSC functions declined in a TB4
Autor:
Cynthia D. Guy, Lixin Zhu, Ruixin Zhu, Patrizia Farci, Wensheng Liu, Sugantha Govindarajan, Fausto Zamboni, Dingfeng Wu, Susan S. Baker, Zhiwei Cao, Anna Mae Diehl, Manal F. Abdelmalek, Cynthia A. Moylan, Robert D. Baker, Weili Lin
Publikováno v:
The Journal of Pathology. 238:531-542
Obese animals and non-alcoholic fatty liver disease (NAFLD) patients exhibit elevated blood alcohol, suggesting potential contributions of alcohol metabolism to the development of NAFLD. Liver gene expression in patients with biopsy-proven mild (N =
Autor:
Thiago A. Pereira, Isaac S. Chan, Márcia Maria de Souza, Wing-Kin Syn, Vivian Resende, Steve S. Choi, Alba Otoni, Mariana Verdelho Machado, Anna Mae Diehl, Guilherme Vaz de Melo Trindade, Paula Vieira Teixeira Vidigal, Elisângela Trindade Santos, Izabela Voieta, William Evan Secor, Rafal P. Witek, Zilton A. Andrade, José Roberto Lambertucci, Guanhua Xie, Fausto Edmundo Lima Pereira
Publikováno v:
Clinical Science (London, England : 1979)
Schistosomal egg antigens induce host bile ductular cells to proliferate and produce osteopontin (OPN), a pro-fibrogenic factor that stimulates hepatic stellate cells to become myofibroblasts. The numbers of OPN-producing bile ductules correlate with