Zobrazeno 1 - 10
of 2 738
pro vyhledávání: '"A. Neal"'
Publikováno v:
Pediatric Neurology. 125:26-31
In tuberous sclerosis, most cardiac rhabdomyomas regress spontaneously. In some cases, the tumors can cause life-threatening hemodynamic compromise requiring subsequent surgical resection. The mechanistic target of rapamycin inhibitors everolimus and
Autor:
Alison E. Smith, Pedram Razavi, Amanda Kulick, Elisa de Stanchina, Enrique Javier Arenas Lahuerta, Anton Safonov, Neal Rosen, Dara S. Ross, Emanuela Ferraro, Sarat Chandarlapaty, Cristina Bernadó Morales, Joaquín Arribas, Qing X. Li, Jorge S. Reis-Filho, David B. Solit
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nature Communications
Inhibition of HER2 in HER2-amplified breast cancer has been remarkably successful clinically, as demonstrated by the efficacy of HER-kinase inhibitors and HER2-antibody treatments. Whilst resistance to HER2 inhibition is common in the metastatic sett
Autor:
Yuan Wu, Chester Kao, Tian Zhang, Neal Ready, Michael B. Datto, Eric Powers, Jeffrey M. Clarke, John H. Strickler, Michelle F. Green
Publikováno v:
Clinical Lung Cancer. 22:500-509
Introduction A high tumor mutational burden (TMB) (≥10 mut/Mb) has been associated with improved clinical benefit in non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICI) and is a tumor agnostic indication for pembroliz
Autor:
Mark G. Kris, Kavitha J Ramachandran, Michael Lanuti, Lecia V. Sequist, James Huang, Jamie E. Chaft, Joseph B. Shrager, Deepa Rangachari, Christopher G. Azzoli, Zofia Piotrowska, Mark S. Huberman, Daniel B. Costa, Alona Muzikansky, Joel W. Neal
Publikováno v:
JCO Precision Oncology. :325-332
PURPOSE For patients with surgically resected disease, multiple studies suggest a benefit of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in delaying cancer recurrence. The necessary duration of therapy for benefit is unk
Publikováno v:
Pediatric Nephrology. 36:4003-4007
Previous studies have demonstrated residual complement-mediated deposits in repeat kidney biopsies of C3 glomerulopathies (C3G) (dense deposit disease (DDD) and C3 glomerulonephritis) following eculizumab treatment, despite some clinical improvement.
Autor:
Hiroko Shimura, Kae Hashimoto, Kenjiro Sawada, Aya Nakae, Justin Y. Newberg, Tadashi Kimura, Michiko Kodama, Jean C. Tien, Neal G. Copeland, Airi Kuruma, Kosuke Yoshihara, Takahiro Kodama, Zhubo Wei, Nancy A. Jenkins, Roberto Rangel
Publikováno v:
Cancer Research. 81:5413-5424
Uterine leiomyosarcoma (ULMS) is a malignancy, which arises from the uterine smooth muscle. Because of its rarity, aggressive nature, and extremely poor prognosis, the molecular mechanisms driving ULMS remain elusive. To identify candidate cancer gen
Publikováno v:
Nucleic Acids Research. 49:10203-10206
Autor:
Hsuan-An Chen, Samuel Haywood, Ninghui Mao, Neal Rosen, Zeda Zhang, Brett S. Carver, Charles L. Sawyers, Dan Li, Qing Chang, Andrew C. Hsieh, Elisa de Stanchina, Xiaoping Chen, Danielle Choi, Yu Chen, Young Sun Lee, Cindy Lee, Aura Agudelo Rivera, Guotai Xu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Previous studies have suggested that PTEN loss is associated with p110β signaling dependency, leading to the clinical development of p110β-selective inhibitors. Here we use a panel pre-clinical models to reveal that PI3K isoform dependency is not g
Autor:
Leon Fouche, Greg Glenn, Susan Neal, Chijioke Bennett, Anthonet Koen, Tulio de Oliveira, Andreana Robertson, Asha Thombrayil, Natasha Lalloo, Lee Fairlie, Gary Albert, Iksung Cho, Mingzhu Zhu, Aylin Oommen-Jose, Zaheer Hoosain, Lou Fries, Sherika Hanley, Vicky L Baillie, Moherndran Archary, As'Ad E. Bhorat, Michele Tameris, Aliasgar Esmail, Pieter Louis Vollgraaff, Shabir A. Madhi, Filip Dubovsky, Sutika Bhikha, Friedrich G. Petrick, Annah Pitsi, Sharne Foulkes, Nazira Carrim-Ganey, Keertan Dheda, Ameena Ebrahim Goga, Gertruida Kruger, Angelique Kany Kany Luabeya, Joyce S. Plested, Dhayendre Moodley, Emmanuel Faust, Nishanta Singh, Q E Bhorat, Coert Grobbelaar, Shane Cloney-Clark, Umesh G. Lalloo, Johan Lombaard, Vivek Shinde, Mduduzi Masilela, Khatija Ahmed, Gabriella Benade, Cheryl Louw, Rosie Mngqibisa
Publikováno v:
The New England Journal of Medicine
BACKGROUND: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants threatens progress toward control of the coronavirus disease 2019 (Covid-19) pandemic. In a phase 1-2 trial involving healthy adults, the NVX-CoV2373 n
Autor:
Jiang Chen, Anna M. Westermark, Lewis C. Cantley, Rakesh K. Jain, Brendan Prideaux, John M. Asara, Clary B. Clish, David P. Kodack, Neal I. Lindeman, Christopher W. Ng, Gino B. Ferraro, Ivy X. Chen, Costas A. Lyssiotis, Keene L. Abbott, Ahmed Ali, Jens Nielsen, Zohreh Amoozgar, Dai Fukumura, Raphael Ferreira, Dan G. Duda, Mark Duquette, David E. Housman, Jessica M. Possada, Véronique Dartois, Kamila Naxerova, Shawn M. Davidson, Xin Jin, Matthew G. Vander Heiden, Sylvie Roberge, Todd R. Golub, Amy Deik, Christopher R. Chin, Divya Bezwada, Elena F. Brachtel, Alba Luengo, Landry Blanc
Publikováno v:
Nature Cancer. 2:414-428
Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2 (HER2+) breast cancer, and the brain microenvironment contributes to this therapy resistance. Nutrient availability c