Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Su, Hao"'
Publikováno v:
Biochimica et biophysica acta. Molecular cell research, vol 1866, iss 3
Spatial and temporal subcellular localization plays critical roles in regulating protein function. Cten (C-terminal tensin like) is a member of the tensin family. Cten recruits signaling molecules, such as DLC1, to focal adhesions, modulates homeosta
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 40
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 40
The cytoskeleton provides structural integrity to cells and serves as a key component in mechanotransduction. Tensins are thought to provide a force-bearing linkage between integrins and the actin cytoskeleton; yet, direct evidence of tensin’s role
Autor:
Su Hao Lo
Publikováno v:
The international journal of biochemistry & cell biology, vol 51, iss 1
C-terminal tensin-like (cten, also known as tensin4, TNS4) is a member of the tensin family. Cten protein, like the other three tensin family members, localizes to focal adhesion sites but only shares sequence homology with other tensins at its C-ter
Publikováno v:
Developmental Biology. 279:368-377
Tensin family is a group of focal adhesion proteins that interact with integrins, actin, and phosphotyrosine-containing proteins. To explore the in vivo functions of a new member of the family, tensin3, we have generated mutant mice with a disrupted
Publikováno v:
Biochemical Journal. 351:403-411
Tensin is a focal-adhesion molecule that binds to actin filaments and interacts with phosphotyrosine-containing proteins. To analyse tensin's function in mammals, we have cloned tensin cDNAs from human and cow. The isolated approx. 7.7-kb human cDNA
Activation of EGF receptor (EGFR) triggers signaling pathways regulating various cellular events that contribute to tissue development and function. Aberrant activation of EGFR contributes to tumor progression as well as therapeutic resistance in pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48e59306c4072c6dec6234f734b2028
https://europepmc.org/articles/PMC3745516/
https://europepmc.org/articles/PMC3745516/
Publikováno v:
Journal of Biological Chemistry. 271:23452-23457
Tensin is an SH2 domain-containing cytoskeletal protein that binds to and caps actin filaments. Investigation of signal transduction mechanisms associated with tensin revealed the presence of phosphoinositide 3-kinase (PI 3-kinase) activity in tensin
Publikováno v:
The Journal of Cell Biology
Tensin, a 200-kD phosphoprotein of focal contacts, contains sequence homologies to Src (SH2 domain), and several actin-binding proteins. These features suggest that tensin may link the cell membrane to the cytoskeleton and respond directly to tyrosin
Publikováno v:
Cancer research. 69(11)
C-terminal tensin-like (cten) is a focal adhesion molecule belonging to the tensin family. Previous studies have suggested that cten may function as a prostate-specific tumor suppressor. Here, we show that although cten is expressed at a very low lev
Autor:
Thomas M. Roberts, Michael L. Lu, Shin Lin, James A. Butler, Brian Druker, Lan Bo Chen, Qi An, Su Hao Lo, Samuel Davis
Publikováno v:
Science. 252:712-715
The molecular cloning of the complementary DNA coding for a 90-kilodalton fragment of tensin, an actin-binding component of focal contacts and other submembraneous cytoskeletal structures, is reported. The derived amino acid sequence revealed the pre