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Autor:
Aamir Ahmad, Gjumrakch Aliev, Guang Yang, Valentin Pavlov, Ilgiz Gareev, Ozal Beylerli, Aferin Beilerli
Publikováno v:
Seminars in Cancer Biology. 83:242-252
Circular RNAs (circRNAs) are a class of single-stranded closed non-coding RNA molecules (ncRNAs), which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, an interest in understanding their regulatory importance is
Autor:
Ronghui Yang, Lu Kong, Ying Zhou, Ping Zhou, Lingkun Zuo, Mahrukh Latif, Hui Ma, Liyong Wang, Miao Wang
Publikováno v:
Genes & Diseases. 9:1086-1098
Epithelial-to-mesenchymal transition (EMT) activation is important in cancer progression and metastasis. Evidence indicates that nc886 is a representative Pol III gene that processes microRNA products via Dicer and further downregulates its target ge
Publikováno v:
Nat Struct Mol Biol
Organismal growth and development rely on RNA Polymerase II (RNAPII) synthesizing the appropriate repertoire of messenger RNAs (mRNAs) from protein-coding genes. Productive elongation of full-length transcripts is essential for mRNA function, however
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, In press, ⟨10.1093/nar/gkac346⟩
Nucleic Acids Research, In press, ⟨10.1093/nar/gkac346⟩
Promoters and enhancers are sites of transcription initiation (TSSs) and carry active histone modifications, including H3K4me1, H3K4me3, and H3K27ac. Yet, the principles governing the boundaries of such regulatory elements are still poorly characteri
Autor:
Matthew D. R. Cadorin
In most eukaryotes, the largest subunit of RNAPII, Rpb1, contains a conserved carboxyterminal domain (CTD) containing a canonical structure of heptapeptide repeats. Two protein complexes of interest, Mediator and Integrator, are known to interact wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545c564733d1df8aa25ab43301da4cc3
https://doi.org/10.32920/ryerson.14664858.v1
https://doi.org/10.32920/ryerson.14664858.v1
Autor:
Henry Yang, Zhi-Hong Jiang, Zhen Long Ng, Yuin-Han Loh, Sue Yu, Jiamin Siew, Yuan Yuan Chew, Ernesto Guccione, Guanxu Ji, Yun Chau Long, Ying Ye, Wensheng Zhang, Wan Ning Lo, Jia Li, Qiang Wu
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:110-128
Chromatin modification contributes to pluripotency maintenance in embryonic stem cells (ESCs). However, the related mechanisms remain obscure. Here, we show that Npac, a "reader" of histone H3 lysine 36 trimethylation (H3K36me3), is required to maint
Publikováno v:
Theranostics
Reversible phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (Pol II) is essential for gene expression control. How altering the phosphorylation of the CTD contributes to gene expression in mammalian systems remains poorly understoo
Autor:
Alina Tarsalainen, Anni Soikkeli, Frederic W Alt, Minna K. Kyläniemi, Jessica J. McDonald, David G. Schatz, Fei-Long Meng, Paulina Budzynska, Yaakov Maman, Filip Šenigl, Jukka Alinikula
Publikováno v:
The Journal of Immunology. 208:143-154
Somatic hypermutation (SHM) drives the genetic diversity of Ig genes in activated B cells and supports the generation of Abs with increased affinity for Ag. SHM is targeted to Ig genes by their enhancers (diversification activators [DIVACs]), but how
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
DNA double-strand breaks are among the most toxic lesions that can occur in a genome and their faithful repair is thus of great importance. Recent findings have uncovered local transcription that initiates at the break and forms a non-coding transcri
Publikováno v:
Methods
Circular RNAs with covalently linked ends are generated from many eukaryotic protein-coding genes when the pre-mRNA splicing machinery backsplices. These mature transcripts are resistant to digestion by exonucleases and typically have much longer hal