Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Allison Berger"'
Autor:
Alexey V. Danilov, Jennifer R. Brown, J. Claire Godbersen, Cody Paiva, Olga V. Danilova, Allison Berger
Publikováno v:
Leukemia & Lymphoma. 56:1566-1569
Chronic lymphocytic leukemia (CLL) B-cells demonstrate both constitutive and stroma-mediated activation of nuclear factor-κB (NF-κB). NEDD8, a ubiquitin-like protein, regulates activity of Cullin-RING ubiquitin ligases (CRLs) and thus indirectly co
Autor:
Xiaozhen J. Liu, Eric S. Lightcap, Allison Berger, Khristofer Garcia, Jonathan L. Blank, Erik Koenig, David C. Bouck, Mike Kuranda, Hugues Bernard
Publikováno v:
Molecular Cancer Therapeutics. 14:C55-C55
Platinum-based therapies, both cisplatin and carboplatin, are utilized as part of first-line standard of care regimens for advanced non-small cell lung cancer (NSCLC), but overall response rate and overall survival remain limited, with a 5-year survi
Autor:
K. Cosmopolous, J. Garnsey, Allison Berger, J. Donelan, Pete Smith, Mark Manfredi, T. Traore, M. Mihollen
Publikováno v:
Journal of Clinical Oncology. 29:8594-8594
8594 Background: MLN4924 is a novel, small molecule inhibitor of Nedd8-activating enzyme (NAE) currently in Phase I clinical trials. Conjugation of NEDD8 to cullin scaffold proteins is required for...
Autor:
Peter G. Smith, Russell M. Walker, Michael P. Thomas, Julie Zhang, Cindy Q. Xia, James J. Garnsey, Michael D. Pickard, Allison Berger, Ji Zhang, George Mulligan, Tary Traore
Publikováno v:
Molecular Cancer Therapeutics. 8:B34-B34
NEDD8-Activating Enzyme (NAE) initiates the conjugation of the ubiquitin-like protein NEDD8 to its cellular targets, members of the cullin protein family. NEDD8 conjugation to cullins is known to be essential for the ubiquitination activity of cullin