Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jan Tavernier"'
Autor:
Irma Lemmens, Sven Eyckerman, Annick Verhee, Sam Lievens, Dominiek Catteeuw, Jan Tavernier, Joël Vandekerckhove
Publikováno v:
Nature Methods. 2:427-433
Interactions between proteins are at the heart of the cellular machinery. It is therefore not surprising that altered interaction profiles caused by aberrant protein expression patterns or by the presence of mutations can trigger cellular dysfunction
Autor:
Sheng-Jiun Wu, Daniël Broekaert, Jan Tavernier, Iris Behrmann, Peter C. Heinrich, Lennart Zabeau, Joël Vandekerckhove, Annick Verhee, José Van der Heyden, Irwin Chaiken
Publikováno v:
European Journal of Immunology. 31:1087-1097
IL-5 is a major determinant in the survival, differentiation and effector-functions of eosinophils. It mediates its effect upon binding and activation of a membrane bound receptor (R), composed of a ligand-specific alpha-chain and a beta-chain, share
Autor:
Stephen R. Durham, R. Pfister, Eleanor M. Minshall, Günter Menz, Jan Tavernier, Q. Hamid, A. B. Kay, A. T. C. Kotsimbos, Marc Humbert
Publikováno v:
Journal of Allergy and Clinical Immunology. 99:666-672
Intrinsic asthma is characterized by an increased number of activated eosinophils and macrophages and an increased expression of the hematopoietic growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF) in the bronchial mucosa.This st
Publikováno v:
Journal of Leukocyte Biology. 57:813-819
A characteristic feature of chronic allergic diseases such as asthma is the increase in eosinophil numbers in the inflamed tissue. In light of its specificity for the development of eosinophils, interleukin-5 (IL-5) is considered the most important c
Autor:
Peter Vandenabeele, X. Van Ostade, W B Smith, J. Barbara, J R Gamble, Walter Fiers, Angel F. Lopez, M A Vadas, Jan Tavernier
Publikováno v:
The EMBO Journal. 13:843-850
Human tumour necrosis factor alpha (TNF-alpha) is a pleiotropic cytokine capable of killing mammalian tumour cells in vitro and in vivo, and of enhancing the proinflammatory activity of leucocytes and endothelium, the latter effects limiting its usag
Autor:
Claude Cuvelier, J Van der Heyden, Romain Pauwels, Guy Brusselle, Horst Bluethmann, Johan Kips, Jan Tavernier
Publikováno v:
Europe PubMed Central
To investigate the role of IL-4 in vivo in allergic asthma, we developed a murine model of allergen-induced airway inflammation. Repeated daily exposures of actively immunized C57BL/6 mice to aerosolized ovalbumin (OVA) induced a peribronchial inflam
Autor:
Simon J. Foote, Jacob Harvey Hollis, Dominiek Catteeuw, Koen Venken, Geert van Loo, Margaret J. Morris, Justin P. Rubio, Hui Chen, Dirk Elewaut, Annick Verhee, Cathy J Jensen, Jan Tavernier, Ken Walder, José Van der Heyden, Brian J. Oldfield, Frank Peelman, Sylvie Seeuws, Lennart Zabeau
Publikováno v:
CELLULAR AND MOLECULAR LIFE SCIENCES
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences
The adipocyte-derived cytokine leptin acts as a metabolic switch, connecting the body’s metabolism to high-energy consuming processes such as reproduction and immune responses. We here provide genetic and biochemical evidence that the metabolic and