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Autor:
Nadeem Sayyed, Imran Kazmi, Syed Sarim Imam, Waleed H. Almalki, Muhammad Nadeem, Mohammed M. Ghoneim, Fahad A. Al-Abbasi, Sultan Alshehri, Muhammad Afzal
Publikováno v:
ACS Chemical Neuroscience. 12:4587-4597
The phytogenic flavanol component of the plant Rhusverniciflua Stokes is fustin which is implicated in various disease aliments and has promising therapeutic efficacy and a long history of its uses in the Indian medicinal system. The present study in
Autor:
L. Pivackova, Jan Klimas, Zuzana Kmecova, Eva Velasova, Peter Krenek, E. Malikova, Simona Trubacova, Peter Balis, Gabriel Doka
Publikováno v:
Clinical and Experimental Hypertension. 44:101-112
Background Caveolin-1 (cav-1) plays a role in pulmonary arterial hypertension (PAH). Monocrotaline (MCT)-induced PAH is characterized by a loss of cav-1 in pulmonary arteries; however, less is known regarding its role in the hypertrophied right ventr
Autor:
Serdar Ferit Toprak, Muhammed Ayral
Publikováno v:
Somatosensory & Motor Research. 38:347-352
Introduction Cisplatin (CDDP) is a widely used antineoplastic drug. However, its use is limited due to the ototoxic side effects. In this study, the effects of ethyl pyruvate (EP), known for its antioxidant and anti-inflammatory effects, against CDDP
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:1088-1096
Metabolic side effects of atypical antipsychotics are an important cause of deterioration of cognitive function and failure of drug adherence. The antifatty effect trypsin/chymotrypsin (T/C) and their mechanisms of action remain unclear. To investiga
Autor:
Ekram Nemr Abd Al Haleem, Sawsan Abo Bakr Zaytoon, Fatma Al –Zahraa Mohamed Ibrahim, Hossam M.M. Arafa
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 99:864-874
Peptic ulcers are one of the world's major gastrointestinal disorders, embracing both gastric and duodenal ulcers, and affecting 10% of the world population. The current study aimed to investigate the possible protective effect of tadalafil and pento
Publikováno v:
Journal of Hypertension. 40:117-127
Background We earlier demonstrated that vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit the overexpression of Giα proteins and hyperproliferation that is attributed to the enhanced levels of endogenous II angio
Autor:
William C. Wimley, Camille R. T. Bourgeois, Jing He, Venkateswara R Gogulamudi, Minolfa C. Prieto, Danielle Y Arita, Ryosuke Satou, Justine Jorgensen, Alexis A. Gonzalez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Growing evidence indicates that prorenin receptor (PRR) is upregulated in collecting duct (CD) of diabetic kidney. Prorenin is secreted by the principal CD cells, and is the natural ligand of the PRR. PRR activation stimulates fibrotic factors, inclu
Publikováno v:
Physiol Res
Gamma-glutamyltransferase (GGT), a marker of liver disease, has been shown to be associated with increased risk of diabetes and relative insulin secretion deficiency. However, the mechanism of hepatic Ggt regulation has not been explored fully. In th
Autor:
Naoya Kakutani, Soichiro Hata, Satoshi Maekawa, Shingo Takada, Hideo Nambu, Yoshikuni Obata, Shintaro Kinugawa, Hikaru Hagiwara, Yoshizuki Fumoto, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Ippei Nakano, Katsuma Yamanashi
Publikováno v:
Experimental Physiology. 106:1785-1793
NEW FINDINGS What is the central question of this study? We questioned whether an angiotensin-converting enzyme (ACE) inhibitor prevents skeletal muscle fibrosis in diabetic mice. What is the main finding and its importance? Administration of ACE inh
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 48:1111-1124
Epilepsy is a chronic widely prevalent neurologic disorder, affecting brain functions with a broad spectrum of deleterious consequences. High mobility group box1 (HMGB1) is a nuclear non-histone protein that targets vital cell receptor of toll-like r