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Publikováno v:
Archives of Physiology and Biochemistry. 127:51-60
Context Lactate is the preferred energy substrate for developing testicular germ cells. Diabetes is associated with impaired testicular lactate transport/utilisation, and poor sexual behaviour. Objective To examine the effects of metformin on paramet
Publikováno v:
ACS Chemical Neuroscience. 10:2801-2808
The dopaminergic pathway, comprising projections from the ventral tegmental area to the nucleus accumbens, constitutes the core of the brain reward system. Insufficient food reward caused by dopamine signaling dysfunction in the nucleus accumbens is
Autor:
Mohammed Ashique, Abderrahim Nemmar, Suhail Al Salam, Sirin A. Adham, Aly M. Abdelrahman, Badreldin H. Ali, Mohammed Al Za'abi, Nicole Schupp, Christina Hartmann, P. Manoj, Yousuf Al Suleimani
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 1, Pp 27-39 (2019)
Background/aims SGLT-2 inhibitors have been shown to be nephroprotective in diabetes. Here, we examined if one of these drugs (canagliflozin) could also ameliorate non-diabetic chronic kidney disease (CKD). Methods CKD was induced in rats by feeding
Autor:
Xiang-Yang Xu, Yao Zhang, Teng Xu, Jun Hu, Shao-Juan Yang, Si Jin, Jian-Zhi Wang, Jia-Zhao Xie
Publikováno v:
Neurosci Bull
Hyperhomocysteinemia (Hhcy) is an independent risk factor for Alzheimer’s disease (AD), and insulin-resistance is commonly seen in patients with Hhcy. Liraglutide (Lir), a glucagon-like peptide that increases the secretion and sensitivity of insuli
Autor:
Romana Kanska, Simona Trubacova, Kristina Repova, Lubos Molcan, Ludovit Paulis, Andrej Barta, Stefan Zorad, Peter Stanko, Michaela Adamcova, Fedor Simko, Silvia Aziriova, Tomas Baka, Dominika Kovacova
Publikováno v:
General physiology and biophysics. 38:265-270
This study investigated the effect of lisinopril (angiotensin-converting enzyme inhibitor) on potential behavioural alterations in spontaneously hypertensive rats (SHR). Three groups of 15-17-week-old rats were investigated for 2 weeks: Wistar contro
Autor:
Vahid Khori, Gholamreza Farnoosh, Khadijeh Jamialahmadi, Mohsen Saeidi, Maryam Rajaei, Yahya Jand, Ali Mohammad Alizadeh, Majid Ghayour-Mobarhan, Mirali Polshekan
Publikováno v:
Peptides. 111:142-151
Oxytocin (OT) has a postconditioning effect against the ischemia-reperfusion (I/R) injury. However, its precise cardioprotection mechanism at the early reperfusion phase remains under debate. Our previous study revealed that OT postconditioning (OTpo
Autor:
Taylan Onat, Renad Mammadov, Engin Yildirim, Gulce Naz Yazici, Selçuk Kaplan, Can Turkler, Mukadder Sunar
Publikováno v:
General physiology and biophysics. 38:427-434
The objective of this study is to investigate the effects of nimesulide on ketamine-induced ovarian and uterine toxicity by biochemical and histopathological examinations. Ketamine is an anesthetic agent whose use leads to overproduction of catechola
Autor:
Hidem Fujino, Yoshitada Sakai, Kohei Ono, Noriaki Maeshige, Masayuki Tanaka, Hiroyo Kondo, Toshihiro Akisue, Mihi Takuwa, Ryosuke Nakanish, Tomohiro Matsumoto, Takumi Hirabayashi, Takuya Ikeji, Akihiko Ishihara
Publikováno v:
General physiology and biophysics. 38:237-244
Hyperglycemia impairs oxidative capacity in skeletal muscle. Muscle oxidative capacity is regulated by peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α). Transcutaneous carbon dioxide (CO2) enhances PGC-1α expression in skelet
Autor:
Cynthia Gershome, BaRun Kim, Damon Poburko, Nickolas Saraev, Jagdeep Singh Walia, Somayeh Mojarad Kalkhoran, Sarah Heather Jane Chow
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 316:H89-H105
ATP and norepinephrine (NE) are coreleased from peripheral sympathetic nerve terminals. Whether they are stored in the same vesicles has been debated for decades. Preferential dependence of NE or ATP release on Ca2+ influx through specific voltage-ga
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 30:131-137
Background Development of drug-induced hepatic damage (DIHD) during chemotherapy is the most common reason for interruption in chemotherapy. This study evaluated the hepatoprotective activity of the ethanolic extract of Tamarindus indica stem bark (E